A5060050239- interferon and immune responses
- Cancer Immunotherapy and Biomarkers
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Immune Response and Inflammation
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- NF-κB Signaling Pathways
- Virology and Viral Diseases
- Influenza Virus Research Studies
- Viral Infections and Immunology Research
- Immune cells in cancer
- Endoplasmic Reticulum Stress and Disease
- Cytomegalovirus and herpesvirus research
- Cancer, Stress, Anesthesia, and Immune Response
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- Radiomics and Machine Learning in Medical Imaging
- Endometrial and Cervical Cancer Treatments
- Chemokine receptors and signaling
- Animal Virus Infections Studies
Stanford University
2024-2025
Northwestern University
2025
Ninghai First Hospital Medicare and Health Group
2024
Guangzhou University of Chinese Medicine
2024
Qilu Hospital of Shandong University
2013-2024
Tulane University
2020-2024
First Affiliated Hospital of Fujian Medical University
2024
Fujian Medical University
2024
Wuhan University
2020-2024
Wuhan Institute of Virology
2022-2024
Glioblastoma is the most common and fatal primary brain tumor in adults. Even with maximal resection a series of postoperative adjuvant treatments, median overall survival (OS) glioblastoma patients remains approximately 15 months. The Huashan Hospital glioma bank contains more than 2000 tissue samples long-term follow-up data; almost half these are from patients. Several large databases data have reported outcomes countries other China. We investigated prognosis China compared among...
Animal models of COVID-19 facilitate the development vaccines and antivirals against SARS-CoV-2. The efficacy or may differ in different animal with varied degrees disease. Here, we introduce a mouse model expressing human angiotensin-converting enzyme 2 (ACE2). In this model,
Influenza control strategies rely on annual immunization and require frequent updates of the vaccine, which is not always a foolproof process. Furthermore, current antivirals are also losing effectiveness as new viral strains often refractory to conventional treatments. Thus, there an urgent need find antiviral mechanisms develop therapeutic drugs based these mechanisms. Targeting virus-host interface emerging strategy because host factors controlling replication activity will be ideal...
Pancreatic cancer has the poorest prognosis among all types, due to its late diagnosis and lack of effective therapies. Therefore, identification novel gene targets, which are differentially expressed in pancreatic functionally involved malignant phenotype, is critical achieve early develop therapeutic strategies. microRNAs (miRNAs) small non-coding RNAs, negatively regulate expression their targets. Due various miRNAs play a key role number physiological processes oncogenesis. investigating...
<b><i>Objectives:</i></b> To evaluate the clinical outcomes of gonadotropin-releasing hormone analog (GnRHa) combined with implantation a levonorgestrel-releasing intrauterine system (LNG-IUS) in adenomyosis patients significantly enlarged uteruses. <b><i>Subjects and Methods:</i></b> Twenty-one whose uterine volumes were greater size than at 12 weeks' gestation recruited for study. Subcutaneous injection GnRHa was administrated an interval 28...
Autophagy plays an important role in tumorigenesis. Mitochondrion-associated protein LRPPRC interacts with MAP1S that LC3 and bridges autophagy components microtubules mitochondria to affect flux. Dysfunction of is associated poor survival ovarian cancer patients. Furthermore, elevated levels predict shorter overall patients prostate adenocarcinomas or gastric cancer. To understand the tumor development, previously we reported forms a ternary complex Beclin 1 Bcl-2 inhibit autophagy. Here...
Dysregulation of micro RNA (mi ) expression in various cancers and their role cancer progression is well documented. The purpose this study was to investigate the biological miR‐372 human pancreatic adenocarcinoma ( HPAC ). We collected 20 pairs tissues adjacent non‐cancerous detect levels. transfected BXPC ‐3 PANC ‐1 cells with inhibitor/mimics effect on cell proliferation, apoptosis, invasion, migration autophagy. In addition, mimics a tumor protein UNC 51‐like kinase 1 ULK 1) si were...
Propranolol suppresses tumor growth in a variety of preclinical solid models, with number proposed cell signaling and immunological mechanisms. We want to confirm the potential mechanisms, including reduced phosphorylation AKT/MAPK pathways, as well enhanced CD8 + T‐cell–mediated antitumor immune response. To clarify mechanism propranolol activity colorectal cancer, therapeutic was then assessed CT26WT tumors engrafted BALB/C mice. Then effect treatment also examined by randomizing patients...
The DNA sensor cGAS detects cytosolic and instigates type I interferon (IFN) expression. Recent studies find that also localizes in the nucleus binds chromatin. Despite mechanism controlling nuclear activation is well elucidated, whether participates sensing unclear. Here, we report herpes simplex virus 1 (HSV-1) infection caused release of from chromatin into soluble fraction. Like its counterpart, leaked sensed viral DNA, produced cGAMP, induced mRNA expression IFN interferon-stimulated...
Abstract NF-κB signaling regulates diverse processes such as cell death, inflammation, immunity, and cancer. The activity of is controlled by methionine 1-linked linear polyubiquitin, which assembled the ubiquitin chain assembly complex (LUBAC) ubiquitin-conjugating enzyme UBE2L3. Recent studies found that deubiquitinase OTULIN breaks chain, thus inhibiting signaling. Despite essential role in has been established, regulatory mechanism for not well elucidated. To discover potential...
Retinoblastoma (RB) is the most common intraocular tumor among children. Leucine-rich pentatricopeptide repeat (PPR)-motif-containing protein (LRPPRC), a suppressor gene of autophagy, has been proven to play regulatory role in progression. However, little known about functional roles and mechanisms LRPPRC RB First, we performed detailed analysis for normal control. The expression tissues was significantly higher than that tissues. Moreover, suppression could repress cell migration, invasion,...
A new antibody diagnostic assay with more rapid and robust properties is demanded to quantitatively evaluate anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity in a large population. Here, we developed nanometer-scale fluorescent biosensor system consisting of CdSe-ZnS quantum dots (QDs) coupled the highly sensitive B-cell epitopes SARS-CoV-2 that could remarkably identify corresponding detection limit 100 pM. Intriguingly, found fluorescence quenching QDs was...
Immune checkpoint blockade (ICB) therapies display clinical efficacy in microsatellite instable (MSI) endometrial cancer (EC) treatment, the key mechanism of which is reversing T cell exhaustion and restoration anti-tumor immunity. Here, we demonstrate that transcription factor 19 (TCF19), one most significantly differentially expressed genes between MSI stable (MSS) patients The Cancer Genome Atlas (TCGA)-EC cohort, associated with poor prognosis immune signature. Specifically, TCF19...
Abstract H3K27M-mutant diffuse midline gliomas (DMG) are aggressive pediatric brain tumors with dismal prognoses and no effective treatments. GD2, a disialoganglioside overexpressed on DMG cells, is promising target for chimeric antigen receptor (CAR) T cell therapy. In Arm A of the Phase I clinical trial (NCT04196413), 12 patients (11 study) received GD2-CAR cells through an initial intravenous (IV) infusion, if had or radiographic improvement, they subsequently intracerebroventricular...
Vesicular stomatitis virus (VSV) is a zoonotic, negative-stranded RNA of the family Rhabdoviridae. The nucleoprotein (N) VSV protects viral genomic and plays an essential role in transcription replication, which makes ideal target host defense. However, whether how innate/intrinsic immunity limits infection by targeting N protein are unknown. In this study, we found that (VSV-N) interacted with ubiquitin E3 ligase, tripartite motif 41 (TRIM41). Overexpression TRIM41 inhibited infection....