A5062926912- Trace Elements in Health
- Microbial metabolism and enzyme function
- Biochemical Acid Research Studies
- Gut microbiota and health
- Adipose Tissue and Metabolism
- Aldose Reductase and Taurine
- Heavy Metal Exposure and Toxicity
- Eicosanoids and Hypertension Pharmacology
- RNA regulation and disease
- RNA modifications and cancer
- Diet and metabolism studies
- Nutrition, Genetics, and Disease
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Ferroptosis and cancer prognosis
- Antioxidant Activity and Oxidative Stress
- Mitochondrial Function and Pathology
- Folate and B Vitamins Research
- Iron Metabolism and Disorders
- IL-33, ST2, and ILC Pathways
- Renal Diseases and Glomerulopathies
- Metabolism and Genetic Disorders
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
Oklahoma State University
2015-2024
Oklahoma State University Oklahoma City
2019-2022
Marine Biological Laboratory
2013-2016
University of California, Davis
2005-2014
Cellular Dynamics International (United States)
2013
Woodwell Climate Research Center
2013
University of California, Berkeley
2000
Breast milk normally contains adequate zinc to meet infant requirements up six months of age; however, transient neonatal deficiency has been documented in exclusively breastfed infants women with low concentration. This condition is not corrected by maternal supplementation, supporting the speculation that it results from an inherited genetic condition. We identified a family which two breast-fed developed was associated concentration both women. Sequencing genomic DNA detected mis-sense...
Bioactive compounds reported to stimulate mitochondrial biogenesis are linked many health benefits such increased longevity, improved energy utilization, and protection from reactive oxygen species. Previously studies have shown that mice rats fed diets lacking in pyrroloquinoline quinone (PQQ) reduced content. Therefore, we hypothesized PQQ can induce mouse hepatocytes. Exposure of Hepa1-6 cells 10-30 microm for 24-48 h resulted citrate synthase cytochrome c oxidase activity, Mitotracker...
Zn 2+ is required for many aspects of neuronal structure and function. However, the regulation in nervous system remains poorly understood. Systematic analysis tissue-profiling microarray data showed that zinc transporter ZIP12 ( slc39a12 ) highly expressed human brain. In work reported here, we confirmed a uptake with conserved pattern high expression mouse Xenopus system. Mouse neurons Neuro-2a cells produce fewer shorter neurites after knockdown without affecting cell viability. chelation...
Pyrroloquinoline quinone (PQQ) influences energy-related metabolism and neurologic functions in animals. The mechanism of action involves interactions with cell signaling pathways mitochondrial function. However, little is known about the response to PQQ humans. Using a crossover study design, 10 subjects (5 females, 5 males) ingested added fruit-flavored drink two separate studies. In 1, was given single dose (0.2 mg PQQ/kg). Multiple measurements plasma urine levels changes antioxidant...
Epithelial-to-mesenchymal transition (EMT) is an essential mechanism for development and wound healing, but in cancer it also mediates the progression spread of aggressive tumors while increasing therapeutic resistance. Adoption a mesenchymal state associated with increased iron uptake, relationship between EMT key regulators cellular metabolism remains undefined. In this regard, human adrenal cortical carcinoma SW13 cell line represents invaluable research model as HDAC inhibitor treatment...
We have reported that pyrroloquinoline quinone (PQQ) improves reproduction, neonatal development, and mitochondrial function in animals by mechanisms involve related cell signaling pathways. To extend these observations, the influence of PQQ on energy lipid relationships apparent protection against ischemia reperfusion injury are described herein. Sprague-Dawley rats were fed a nutritionally complete diet with added at either 0 (PQQ−) or 2 mg PQQ/Kg (PQQ+). Measurements included: 1) serum...
The majority of ovarian tumors eventually recur in a drug resistant form. Using cisplatin sensitive and cell lines assembled into 3D spheroids we profiled gene expression identified candidate mechanisms biological pathways associated with resistance. OVCAR-8 human carcinoma cells were exposed to sub-lethal concentrations create matched cisplatin-resistant line, OVCAR-8R. Genome-wide profiling cancer 3,331 significantly differentially expressed probesets coding for 3,139 distinct...
The tumor suppressor gene TP53 is the most commonly mutated in human cancer. In addition to loss of functions, mutations promote cancer progression by altering cellular iron acquisition and metabolism. A newly identified role for coordination homeostasis cell survival lies ability protect against ferroptosis, a form iron-mediated death. purpose this study was determine extent which mutation status affects response ferroptosis induction. Using H1299 cells, are null TP53, we generated lines...
Abstract Prenatal and early postnatal zinc deficiency impairs learning memory these deficits persist into adulthood. A key modulator in this process may be the NMDA receptor; however, effects of on regulation receptor activity are not well understood. Female Sprague‐Dawley rats were fed diets containing 7 (zinc deficient, ZD), 10 (marginally MZD) or 25 (control) mg Zn/g diet preconception through day (PN) 20, at which time pups weaned onto their maternal control diet. Regulation expression...
PQQ (pyrroloquinoline quinone) improves energy utilization and reproductive performance when added to rodent diets devoid of PQQ. In the present paper we describe changes in gene expression patterns transcriptional networks that respond dietary restriction or pharmacological administration. Rats were fed either deficient (PQQ-) supplemented with (approx. 6 nmol PQQ/g food; PQQ+). addition, groups rats repleted by administering PQQ- (1.5 mg intraperitoneal/kg body weight at 12 h intervals for...
The zinc transporter ZIP12, which is encoded by the gene slc39a12, has previously been shown to be important for neuronal differentiation in mouse Neuro-2a neuroblastoma cells and primary neurons necessary neurulation during Xenopus tropicalis embryogenesis. However, relatively little known about biochemical properties, cellular regulation, or physiological role of this gene. hypothesis that ZIP12 a nervous system function development guided comparative genetics approach uncover presence...