A5100404970- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Organometallic Compounds Synthesis and Characterization
- ZnO doping and properties
- Synthesis and biological activity
- Crystal structures of chemical compounds
- Computational Drug Discovery Methods
- Ga2O3 and related materials
- Natural product bioactivities and synthesis
- GaN-based semiconductor devices and materials
- Asymmetric Synthesis and Catalysis
- Marine Biology and Environmental Chemistry
- Biochemical and Molecular Research
- Melanoma and MAPK Pathways
- Phytochemical compounds biological activities
- Quantum Dots Synthesis And Properties
- Bioactive Compounds and Antitumor Agents
- Cancer Immunotherapy and Biomarkers
- Magnetism in coordination complexes
- Anodic Oxide Films and Nanostructures
- Traditional Chinese Medicine Analysis
- Peroxisome Proliferator-Activated Receptors
- Synthesis and Catalytic Reactions
- Nanowire Synthesis and Applications
Shanxi Medical University
2016-2025
Shanxi University
1996-2025
University of Illinois Chicago
2025
Chengde Medical University
2017-2024
Shanxi University of Traditional Chinese Medicine
2017-2024
Hefei University of Technology
2013-2024
Xi'an Polytechnic University
2024
Zhengzhou University
2023
Henan Provincial People's Hospital
2023
Huazhong University of Science and Technology
2006-2022
Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide and fourth lethal cancer in China. However, although genomic studies have identified some mutations associated with ESCC, we know little mutational processes responsible. To identify genome-wide signatures, performed either whole-genome sequencing (WGS) or whole-exome (WES) on 104 ESCC individuals combined our data those 88 previously reported samples. An APOBEC-mediated signature 47% 192 tumors suggests...
Comprehensive identification of somatic structural variations (SVs) and understanding their mutational mechanisms in cancer might contribute to biological differences help identify new therapeutic targets. Unfortunately, characterization complex SVs across the whole genome underlying esophageal squamous cell carcinoma (ESCC) is largely unclear. To define a comprehensive catalog SVs, affected target genes, ESCC, we re-analyzed whole-genome sequencing (WGS) data from 31 ESCCs using Meerkat...
Selenium nanoparticles (SeNPs) have attracted worldwide attention due to their unique properties and potential bioactivities. Considering that hawthorn is both a traditional medicine common edible food, fruit extract (HE) was chosen as reductant prepare SeNPs.SeNPs were synthesized by using an aqueous HE stabilizer. The antitumor activities mechanisms of SeNPs explored series cellular assays.The mediated (HE-SeNPs) examined various characterisation methods. cytotoxicity measured against...
Abstract Background QL1706 (PSB205) is a single bifunctional MabPair (a novel technical platform) product consisting of two engineered monoclonal antibodies (anti-PD-1 IgG4 and anti-CTLA-4 IgG1), with shorter elimination half-life (t 1/2 ) for CTLA-4. We report results from phase I/Ib study in patients advanced solid tumors who failed standard therapies. Methods In the I study, was administered intravenously once every 3 weeks at one five doses ranging 0.3 to 10 mg/kg, maximum tolerated...
The organotin(IV) compounds [Me2Sn(L)2] (1), [Et2Sn(L)2] (2), [nBu2Sn(L)2] (3), [nOct2Sn(L)2] (4), [Ph2Sn(L)2] (5), and [PhOSnL]6 (6) have been synthesized from the reactions of 1-(4-chlorophenyl)-1-cyclopentanecarboxylic acid (HL) with corresponding diorganotin(IV) oxide or dichloride. They were characterized by IR multinuclear NMR spectroscopies, elemental analysis, cyclic voltammetry, and, for 2, 3, 4 6, single crystal X-ray diffraction analysis. While 1–5 are mononuclear compounds, 6...
Copper iodide (CuI) thin films were grown on Si(100) substrates using a copper film iodination reaction method. It was found that γ-CuI have uniform and dense microstructure with (111)-orientation. Transmission spectra indicated CuI an average transmittance of about 60% in the visible range optical band gap is 3.01 eV. By checking effect thickness Cu annealing condition photoluminescence (PL) character films, luminescence mechanisms been comprehensively analyzed, origin different PL...
Abstract A series of diorganotin( IV ) and dichlorotin( derivatives 4‐X‐benzohydroxamic acids, [HL 1 (X = Cl) or HL 2 OCH 3 )] formulated as [R SnL ] (R Me, Et, n Bu, Ph Cl; L ), along with their corresponding mixed‐ligand complexes Sn(L )(L have been prepared characterized by FT‐IR, H, 13 C, 119 Sn NMR spectroscopy, mass spectrometry, elemental analysis, melting points. In addition, single‐crystal X‐ray diffraction analyses were carried out for [Me (L which show coordination structures...
Oxidative stress plays a critical role in endothelial injury and the pathogenesis of diverse cardiovascular diseases, including atherosclerosis. Isoquercitrin (quercetin-3-glucoside), flavonoid distributed widely plants, exhibits many biological activities, anti-allergic, anti-viral, anti-inflammatory, anti-oxidative effects. In present study, inhibitory effect isoquercitrin on H2O2-induced apoptosis EA.hy926 cells was evaluated. MTT assays showed that significantly inhibited loss viability...
Abstract Lung cancer is the most common cause of cancer-related deaths worldwide and caused by multiple factors, including high-fat diet (HFD). CD36, a fatty acid receptor, closely associated with metabolism-related diseases, cardiovascular disease cancer. However, role CD36 in HFD-accelerated non-small-cell lung (NSCLC) unclear. In vivo , we fed C57BL/6J wild-type (WT) knockout (CD36 −/− ) mice normal chow or HFD presence absence pitavastatin 2 weeks before subcutaneous injection LLC1...
Abstract In this study, total flavonoids and triterpenoid acid were extracted with ethyl acetate from Hedyotis diffusa Willd, hepatoprotective activities of them five compounds against H 2 O induced hepatocyte damage on HL‐02 cells determined. particular, amentoflavone had influence the leakage ALT, AST, LDH, SOD content MDA. They effectively reduced loss MMP, release Cyt C, then inhibited activation caspase‐3/caspase‐9 cascade in hepatotoxic cells. The contents ROS significantly to inhibit...
Studies have shown that the abnormal activation of NLRP3 inflammasome is involved in a variety inflammatory-based diseases. In this study, high content screening model targeting was first established and pterostilbene discovered as active scaffold. Based on finding, total 50 derivatives were then designed synthesized. Among them, compound 47 found to be best one for inhibiting cell pyroptosis [inhibitory rate (IR) = 73.09% at 10 μM], showing low toxicity efficiency [against interleukin-1β...
In this study, the effects of Peucedanum praeruptorum DUNN methanolic extract (PPME) and its major constituents on SGC7901 human gastric cancer cells were evaluated. Two pyranocoumarins, namely, (±) praeruptorin A (PA) B (PB), isolated from PPME. high performance liquid chromatographic (HPLC) method was developed to determine contents PA PB in The antiproliferative cytotoxic actions PPME observed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) release lactate...