A5107244586- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Plant Pathogenic Bacteria Studies
- Plant Disease Resistance and Genetics
- Genomics and Phylogenetic Studies
- Microbial Metabolic Engineering and Bioproduction
- Plant-Microbe Interactions and Immunity
- Birth, Development, and Health
- Bacteriophages and microbial interactions
- Plant Pathogens and Fungal Diseases
- Lipid metabolism and biosynthesis
- Hepatitis C virus research
- Mosquito-borne diseases and control
- COVID-19 epidemiological studies
- Plant responses to water stress
- Inflammatory Biomarkers in Disease Prognosis
- Plant pathogens and resistance mechanisms
- RNA and protein synthesis mechanisms
- SARS-CoV-2 detection and testing
- Epigenetics and DNA Methylation
- Viral Infections and Vectors
- Neonatal Respiratory Health Research
- COVID-19 diagnosis using AI
- Biosensors and Analytical Detection
Anhui Provincial Children's Hospital
2025
Wuhan University
2011-2024
State Key Laboratory of Virology
2024
Wenzhou Medical University
2024
Chinese PLA General Hospital
2024
Affiliated Eye Hospital of Wenzhou Medical College
2024
Beijing Forestry University
2005-2023
Nanjing Drum Tower Hospital
2023
Shandong Provincial Hospital
2023
Shandong First Medical University
2023
Circulating in China and 158 other countries areas, the ongoing COVID-19 outbreak has caused devastating mortality posed a great threat to public health. However, efforts identify effectively supportive therapeutic drugs treatments been hampered by our limited understanding of host immune response for this fatal disease. To characterize transcriptional signatures inflammatory SARS-CoV-2 (HCoV-19) infection, we carried out transcriptome sequencing RNAs isolated from bronchoalveolar lavage...
From December 2019, an outbreak of unusual pneumonia was reported in Wuhan with many cases linked to Huanan Seafood Market that sells seafood as well live exotic animals. We investigated two patients who developed acute respiratory syndromes after independent contact history this market. The shared common clinical features including fever, cough, and multiple ground-glass opacities the bilateral lung field patchy infiltration. Here, we highlight use a low-input metagenomic next-generation...
Quantitative real time PCR (RT-PCR) is widely used as the gold standard for clinical detection of SARS-CoV-2. However, due to low viral load specimens and limitations RT-PCR, significant numbers false negative reports are inevitable, which results in failure timely diagnose, cut off transmission, assess discharge criteria. To improve this situation, an optimized droplet digital (ddPCR) was SARS-CoV-2, showed that limit ddPCR significantly lower than RT-PCR. We further explored feasibility...
Abstract Background The ongoing new coronavirus pneumonia (Corona Virus Disease 2019, COVID-19) outbreak is spreading in China, but it has not yet reached its peak. Five million people emigrated from Wuhan before lockdown, potentially representing a source of virus infection. Determining case distribution and correlation with population emigration the early stage epidemic great importance for warning prevention future outbreaks. Methods official report on COVID-19 was collected as January...
Abstract National-based prospective surveillance of all-age patients with acute diarrhea was conducted in China between 2009‒2018. Here we report the etiological, epidemiological, and clinical features 152,792 eligible enrolled this analysis. Rotavirus A norovirus are two leading viral pathogens detected patients, followed by adenovirus astrovirus. Diarrheagenic Escherichia coli nontyphoidal Salmonella bacterial pathogens, Shigella Vibrio parahaemolyticus . Patients aged <5 years had...
Recent studies have suggested a key role of intestinal microbiota in pathological progress multiple organs via immune modulation. However, the interactions between heart and gut remain to be fully elucidated. The aim study is investigate post-ischaemia/reperfusion (I/R) inflammatory microenvironment.Here, we conducted case-control explore association bacteria translocation products with inflammation biomarkers I/R injury severity ST-elevation myocardial infarction patients. Then, used mouse...
BackgroundAzvudine and nirmatrelvir/ritonavir are approved to treat mild-to-moderate coronavirus disease 2019 (COVID-19) in adults with a high risk for progression severe infection. We sought compare the antiviral effectiveness clinical outcomes of elderly patients COVID-19 receiving these two agents.MethodsIn this observational study, we identified 249 infection who were admitted Second Medical Center People's Liberation Army General Hospital from December 2022 January 2023, including 128...
Prenatal dexamethasone exposure (PDE) induces developmental toxicities of multiple organs in offspring. Here, we verified the intergenerational effect low peak bone mass induced by PDE and investigated its intrauterine programming mechanism. Pregnant rats were injected subcutaneously with 0.2 mg/kg/d from gestation day (GD) 9 to 20. Some pregnant killed for fetuses on GD20, rest went spontaneous labor produce first-generation (F1) The adult F1 male offspring mated normal females F2 In vivo,...
Enterovirus 71 (EV71) infection causes hand, foot, and mouth disease (HFMD), even fatal neurological complications. However, the mechanisms underlying EV71 pathogeneses are largely unknown. This study reveals a distinct mechanism by which induces apoptosis autophagy in neural cells. non-structure protein 3D (also known as RNA-dependent RNA polymerase, RdRp) interacts with peroxisomal acyl-CoA oxidase 1 (ACOX1), contributes to ACOX1 downregulation. Further studies demonstrate that reduces...
Dengue virus (DENV) infection causes serious clinical symptoms, including dengue hemorrhagic fever (DHF) and shock syndrome (DSS). Vascular permeability change is the main feature of diseases, abnormal expression proinflammatory cytokines important cause vascular change. However, mechanism underlying induced by DENV has not been fully elucidated. Here, we reveal a distinct which promotes NLRP3 inflammasome activation interleukin-1 beta (IL-1β) release to induce endothelial leakage in mice. M...
The ability of human mesenchymal stem cells (hMSC) to differentiate into osteoblasts was examined through the use osteogenic induction medium (MSCOIM) cultures. hMSC first attached dish surface and exhibited fibroblast-like spindle shapes, after proliferation, formed cuboidal shapes. Calcium assays von Kossa alizarin red S staining showed that were capable mineralization when cultured in MSCOIM. Gene expressions Cbfa-1 BMP-4, which are markers for differentiation, also increased during...
Abstract Real time fluorescent quantitative PCR (RT-PCR) is widely used as the gold standard for clinical detection of SARS-CoV-2. However, due to low viral load in patient throats and limitations RT-PCR, significant numbers false negative reports are inevitable, which results failure timely diagnose, early treat, cut off transmission, assess discharge criteria. To improve this situation, an optimized droplet digital (ddPCR) was SARS-CoV-2, showed that limit ddPCR significantly lower than...
Dengue virus (DENV) infection causes several diseases ranging from dengue fever to life-threatening hemorrhagic and shock syndrome characterized by endothelial dysfunction, vascular leakage, shock. Here, we identify a potential mechanism which DENV induces tissue injury leakage promoting the activation of interleukin (IL)-1β. facilitates IL-1β secretion in infected patients, mice, human peripheral blood mononuclear cells (PBMCs), mouse bone marrow-derived macrophages (BMDMs),...
Two billion people have been infected with HBV worldwide; about 240 million patients developed chronic hepatitis B (CHB), and 650,000 die each year from liver cirrhosis (LC) or hepatocellular carcinoma (HCC). This work elucidates a mechanism underlying the control of replication. infection activates HoxA10, regulator cell differentiation cancer progression, in human cells CHB HCC. HoxA10 subsequently inhibits replication tissue culture mice. Additionally, interacts p38 MAPK to repress...
A new antibody diagnostic assay with more rapid and robust properties is demanded to quantitatively evaluate anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity in a large population. Here, we developed nanometer-scale fluorescent biosensor system consisting of CdSe-ZnS quantum dots (QDs) coupled the highly sensitive B-cell epitopes SARS-CoV-2 that could remarkably identify corresponding detection limit 100 pM. Intriguingly, found fluorescence quenching QDs was...
This study aimed to investigate the factors influencing complication of allergic rhinitis in children with bronchial asthma and construct a nomogram model predict occurrence rhinitis. A total 190 admitted our hospital from August 2020 2024 were retrospectively analyzed. The randomly divided into training cohort (133 cases) validation (57 ratio 7:3. modeling set an group (n=44) nonallergic (n=89) depending on presence or absence concomitant 62 cases had complications rhinitis, incidence...
Abstract Hepatitis B virus (HBV) infection causes acute hepatitis (AHB), chronic (CHB), liver cirrhosis (LC), and eventually hepatocellular carcinoma (HCC). The presence of e antigen (HBeAg) in the serum generally indicates ongoing viral replication disease progression. However, mechanism by which HBeAg regulates HBV remains unclear. Interferons (IFNs) are pleiotropic cytokines that participate host innate immunity. After binding to receptors, IFNs activate JAK/STAT pathway stimulate...