Takeshi Fukumoto
A5009762734- Urticaria and Related Conditions
- Global Health Care Issues
- Global Maternal and Child Health
- Climate Change and Health Impacts
- Chromatin Remodeling and Cancer
- Cancer Mechanisms and Therapy
- Health disparities and outcomes
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Dermatologic Treatments and Research
- Cutaneous Melanoma Detection and Management
- Child Nutrition and Water Access
- melanin and skin pigmentation
- Global Public Health Policies and Epidemiology
- Healthcare Systems and Reforms
- Contact Dermatitis and Allergies
- Mast cells and histamine
- Nail Diseases and Treatments
- Cutaneous lymphoproliferative disorders research
- Skin Diseases and Diabetes
- Cancer Immunotherapy and Biomarkers
- Nonmelanoma Skin Cancer Studies
- Trauma and Emergency Care Studies
- Injury Epidemiology and Prevention
- Melanoma and MAPK Pathways
Kobe University
2016-2025
Kobe City Nishi-Kobe Medical Center
2025
Institute for Health Metrics and Evaluation
2018-2023
Royal North Shore Hospital
2023
The University of Sydney
2023
University of Electronic Science and Technology of China
2023
University of Washington
2018-2022
University of California, Davis
2021
The Wistar Institute
2017-2021
University College London
2021
Acute meningitis has a high case-fatality rate and survivors can have severe lifelong disability. We aimed to provide comprehensive assessment of the levels trends global burden that could help guide introduction, continuation, ongoing development vaccines treatment programmes.
<h2>Summary</h2><h3>Background</h3> Accurate childhood cancer burden data are crucial for resource planning and health policy prioritisation. Model-based estimates necessary because surveillance scarce or non-existent in many countries. Although global incidence mortality available, there no previous analyses of the represented disability-adjusted life-years (DALYs). <h3>Methods</h3> Using Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2017 methodology, (ages 0–19 years) was...
Human resources for health (HRH) include a range of occupations that aim to promote or improve human health. The UN Sustainable Development Goals (SDGs) and the WHO Health Workforce 2030 strategy have drawn attention importance HRH achieving policy priorities such as universal coverage (UHC). Although previous research has found substantial global disparities in HRH, absence comparable cross-national estimates existing workforces hindered efforts quantify workforce requirements meet system...
Cancers represent a challenging public health threat in Asia. This study examines the temporal patterns of incidence, mortality, disability and risk factors 29 cancers Asia last three decades. The age, sex year-wise estimates disability-adjusted life years (DALYs) for 49 Asian countries from 1990 through 2019 were generated as part Global Burden Disease, Injuries Risk Factors study. Besides mortality DALYs, we also examined cancer burden measured terms DALYs deaths attributable to factors,...
Abstract Despite the high initial response rates to PARP inhibitors (PARPi) in BRCA-mutated epithelial ovarian cancers (EOC), PARPi resistance remains a major challenge. Chemical modifications of RNAs have emerged as new layer epigenetic gene regulation. N6-methyladenosine (m6A) is most abundant chemical modification mRNA, yet role m6A has not previously been explored. Here, we show that FZD10 mRNA contributes by upregulating Wnt/β-catenin pathway EOC cells. Global profile revealed...
Epithelial ovarian cancer (EOC) is the most lethal of gynecologic malignancies. The standard-of-care treatment for EOC platinum-based chemotherapy such as cisplatin. Platinum-based induces cellular senescence. Notably, therapy-induced senescence contributes to chemoresistance by inducing stem-like cells (CSC). However, therapeutic approaches targeting senescence-associated CSCs remain be explored. Here, we show that nicotinamide phosphoribosyltransferase (NAMPT) inhibition suppresses induced...
ARID1A, a subunit of the SWI/SNF complex, is among most frequently mutated genes across cancer types. ARID1A in more than 50% ovarian clear cell carcinomas (OCCCs), diseases that have no effective therapy. Here, we show mutation confers sensitivity to pan-HDAC inhibitors such as SAHA cancers. This correlated with enhanced growth suppression induced by inhibition HDAC2 activity ARID1A-mutated cells. interacts EZH2 an status-dependent manner. functions co-repressor suppress expression...
Background As global rates of mortality decrease, non-fatal injury have increased, particularly in low Socio-demographic Index (SDI) nations. We hypothesised this pattern would be demonstrated regard to bony hand and wrist trauma over the 27-year study period. Methods The Global Burden Diseases, Injuries, Risk Factors Study 2017 was used estimate prevalence, age-standardised incidence years lived with disability for 195 countries from 1990 2017. Individual injuries included fractures, thumb...
The epidemiological transition of non-communicable diseases replacing infectious as the main contributors to disease burden has been well documented in global health literature. Less focus, however, given relationship between sociodemographic changes and injury. aim this study was examine association disability-adjusted life years (DALYs) from injury for 195 countries territories at different levels along development spectrum 1990 2017 based on Global Burden Disease (GBD) estimates.Injury...
Therapy-induced senescence-associated secretory phenotype (SASP) correlates with overcoming resistance to immune checkpoint blockade (ICB). Intrinsic ICB is a major clinical challenge. For example, ovarian cancer largely resistant ICB. Here we show that adoptive transfer of SASP-boosted ex vivo therapy-induced senescent cells sensitizes tumor Topoisomerase 1 (TOP1) inhibitors such as irinotecan enhance cisplatin-induced SASP, which depends on the TOP1 cleavage complex-regulated cGAS pathway....
<h3>Importance</h3> Skin and subcutaneous diseases affect the health of millions individuals in US. Data are needed that highlight geographic trends variations skin disease burden across country to guide care decision-making. <h3>Objective</h3> To characterize tissue US from 1990 2017. <h3>Design, Setting, Participants</h3> For this cohort study, data were obtained Global Burden Disease (GBD), a study with an online database incorporates current previous epidemiological studies burden, GBD...
Abstract Cyclic cGMP-AMP synthase (cGAS) is a pattern recognition cytosolic DNA sensor that essential for cellular senescence. cGAS promotes inflammatory senescence-associated secretory phenotype (SASP) through recognizing cytoplasmic chromatin during cGAS-mediated inflammation the antitumor effects of immune checkpoint blockade. However, mechanism by which recognizes unknown. Here we show topoisomerase 1-DNA covalent cleavage complex (TOP1cc) both necessary and sufficient SASP TOP1cc...
Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is still among the leading causes of disease burden mortality in sub-Saharan Africa (SSA), world not on track to meet targets set for ending epidemic by Joint United Nations Programme HIV/AIDS (UNAIDS) Sustainable Development Goals (SDGs). Precise HIV information critical effective geographic epidemiological targeting prevention treatment interventions. Age- sex-specific prevalence estimates are widely available...
Background Estimating and analyzing trends patterns of health loss are essential to promote efficient resource allocation improve Peru’s healthcare system performance. Methods Using estimates from the Global Burden Disease (GBD), Injuries, Risk Factors Study (2019), we assessed mortality disability in Peru 1990 2019. We report demographic epidemiologic terms population, life expectancy at birth (LE), mortality, incidence, prevalence, years lost (YLLs), lived with (YLDs), disability-adjusted...
Abstract Cellular senescence occurs in response to endogenous or exogenous stresses and is characterized by stable cell cycle arrest, alterations nuclear morphology secretion of proinflammatory factors, referred as the senescence-associated secretory phenotype (SASP). An increase senescent cells associated with development several types cancer aging-related diseases. Therefore, senolytic agents that selectively remove may offer opportunities for developing new therapeutic strategies against...