Keyghobad Ghadiri
A5086280096- Pneumonia and Respiratory Infections
- Global Maternal and Child Health
- Global Health Care Issues
- HIV/AIDS Research and Interventions
- Tuberculosis Research and Epidemiology
- Climate Change and Health Impacts
- Health disparities and outcomes
- Monoclonal and Polyclonal Antibodies Research
- Antibiotic Resistance in Bacteria
- vaccines and immunoinformatics approaches
- Respiratory viral infections research
- Bacterial Infections and Vaccines
- HIV, Drug Use, Sexual Risk
- Hepatitis B Virus Studies
- Child Nutrition and Water Access
- Global Public Health Policies and Epidemiology
- Influenza Virus Research Studies
- Research on Leishmaniasis Studies
- Hepatitis Viruses Studies and Epidemiology
- Infectious Diseases and Tuberculosis
- Metabolism and Genetic Disorders
- Healthcare Systems and Reforms
- Mitochondrial Function and Pathology
- Kawasaki Disease and Coronary Complications
- Bacterial biofilms and quorum sensing
Kermanshah University of Medical Sciences
2016-2025
Institute for Health Metrics and Evaluation
2018-2023
University of Washington
2018-2023
Imam Reza Hospital
2023
University College London
2021
BackgroundAlthough the burden of influenza is often discussed in context historical pandemics and threat future pandemics, every year a substantial lower respiratory tract infections (LRTIs) other conditions (like chronic obstructive pulmonary disease) are attributable to seasonal influenza. The Global Burden Disease Study (GBD) 2017 systematic scientific effort quantify health loss associated with comprehensive set diseases disabilities. In this Article, we focus on LRTIs that can be...
Human resources for health (HRH) include a range of occupations that aim to promote or improve human health. The UN Sustainable Development Goals (SDGs) and the WHO Health Workforce 2030 strategy have drawn attention importance HRH achieving policy priorities such as universal coverage (UHC). Although previous research has found substantial global disparities in HRH, absence comparable cross-national estimates existing workforces hindered efforts quantify workforce requirements meet system...
Many countries have shown marked declines in diarrhoeal disease mortality among children younger than 5 years. With this analysis, we provide updated results on years from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) use study's comparative risk assessment to quantify trends effects factors, interventions, broader sociodemographic development changes 195 territories 1990 2017.This analysis for GBD had three main components. Diarrhoea was modelled using...
Klebsiella pneumoniae is a pathogen that causes infections in various parts of the body, with high mortality rates reported antibiotic-resistant cases. Treating at-risk individuals requires crucial vaccination efforts due to challenges exist. This research involved designing multi-epitope vaccine from K. pneumoniae's fimbriae antigens. Optimal T-cell and B-cell epitopes were chosen through silico studies including epitope-HLAs molecular docking. The was created, featuring antigenic T-...
Human brucellosis is a multisystem disease with wide range of clinical signs which often leads to misdiagnosis and treatment delay. Early diagnosis this can prevent the serious complications mismanagements. This study aimed evaluate hematological parameters predictive value for brucellosis.
Klebsiella pneumoniae (K. pneumoniae) is a causative agent of severe infections in humans. There no publically available vaccine for K. yet. Here, using comprehensive immunoinformatics methods, T-cell-specific epitopes four type 1 fimbriae antigens were predicted and evaluated as potential candidates. Both CD8+ (class I) CD4+ II) the similar to human proteome excluded. Subsequently, windows class-II containing class-I determined. The immunogenicity, IFN-γ production population coverage also...
Background: Acinetobacter baumannii is one of the main causes nosocomial infections. No vaccine has yet been licensed for use in humans, and efforts are still ongoing. Objective: In present study, we have predicted B-cell epitopes A. baumannii’s outer membrane protein K (OMPK) by using epitope prediction algorithms as possible candidates future studies. Methods: The linear were seven different tools. 3D structure OMPK was modeled used discontinuous ElliPro DiscoTope 2.0 final segments...
Phenylketonuria (PKU) is an inborn error of amino acid metabolism that results from a deficiency phenylalanine hydroxylase (PAH). According to PAH database, exons 6 and 7 their flanking introns gene contain the greatest number mutant alleles. Therefore, as preliminary study, nucleotide sequence analysis has been performed in 25 PKU patients whose ancestors lived Kermanshah province Iran. To date, there no mutation data describing genotypes disease this Kurdish ethnic region...
Klebsiella pneumoniae is a common cause of nosocomial infections; however, there limited information in Iran regarding outbreaks due to extended-spectrum β-lactamase (ESBL) producing K strains, particularly using molecular methods. The present study focused on the mechanism ESBL resistance and genetic relatedness K. isolates causing infections an Iranian referral hospital.This evaluated antimicrobial epidemiology children between October 2013 March 2014. detection was carried out for all by...
Background: BCG (Bacille Calmette-Guerin) vaccine is an attenuated live administered to prevent Tuberculosis. Disseminated infection due a rare life threatening complication of this vaccine, especially in immunocompromised patients. Objectives: The current study evaluated the sensitivity pattern strain supplied by Institute de Pasteur, Iran against anti-mycobacterial drugs used treat disseminated caused vaccine. Patients and Materials: Bacille Calmette-Guerin ATCC 1173 P was purchased from...