A5011992284- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Vaccine Coverage and Hesitancy
- Antibiotic Resistance in Bacteria
- Transgenic Plants and Applications
- Biochemical and Structural Characterization
Islamic Azad University of Shahrekord
2023-2025
Kermanshah University of Medical Sciences
2023
Islamic Azad University, Tehran
2023
Bridge University
2023
Klebsiella pneumoniae is a pathogen that causes infections in various parts of the body, with high mortality rates reported antibiotic-resistant cases. Treating at-risk individuals requires crucial vaccination efforts due to challenges exist. This research involved designing multi-epitope vaccine from K. pneumoniae's fimbriae antigens. Optimal T-cell and B-cell epitopes were chosen through silico studies including epitope-HLAs molecular docking. The was created, featuring antigenic T-...
Background: Acinetobacter baumannii is one of the main causes nosocomial infections. No vaccine has yet been licensed for use in humans, and efforts are still ongoing. Objective: In present study, we have predicted B-cell epitopes A. baumannii’s outer membrane protein K (OMPK) by using epitope prediction algorithms as possible candidates future studies. Methods: The linear were seven different tools. 3D structure OMPK was modeled used discontinuous ElliPro DiscoTope 2.0 final segments...
The lack of appropriate vaccines is an obstacle to the effective management A. baumannii infections. Peptide offer attractive and promising preventive strategy against baumannii.In this study, we identified specific T cell epitopes outer membrane protein K (OMPK) using comprehensive bioinformatics detailed molecular docking analysis.Both class-I class-II OMPK were predicted by three tools namely IEDB, SYFPEITHI, ProPred. shortlisted based on several analyses including prediction scoring,...
Outer membrane protein W (OmpW) is a less-known A. baumannii antigen with potential immunogenic properties. The epitopes of this are not well-identified yet. Therefore, in the present study, B- and T-cell OmpW were found using comprehensive silico partially vitro studies. (both class-I class-II) B-cell linear conformational) predicted screened through many bioinformatics approaches including prediction IFN-γ production, immunogenicity, toxicity, allergenicity, human similarity, clustering. A...
Abstract Acinetobacter baumannii is a significant cause of hospital-acquired infections and often resistant to multiple antibiotics. In this study, we designed multi-epitope vaccine candidate using the outer membrane protein K (OmpK) A. . T-cell B-cell epitopes were predicted, best selected for design. For selecting epitopes, many in silico studies, as well molecular docking epitope-HLAs, performed. The was β-defensin an adjuvant, PADRE sequence immunogenicity enhancer, appropriate linkers....
Abstract Background The lack of appropriate vaccines is an obstacle to the effective management A. baumannii infections. Peptide can provide attractive and promising preventive strategies against . Objective Here, specific T cell epitopes outer membrane protein K (OMPK) were found using comprehensive bioinformatics detailed molecular docking analysis. Methods Both class-I class-II OMPK predicted by three tools namely IEDB, SYFPEITHI, ProPred. shortlisted via several analyses such as...