A5101887806- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Colorectal and Anal Carcinomas
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Colorectal Cancer Surgical Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Neurological disorders and treatments
- Case Reports on Hematomas
- Neuroendocrine Tumor Research Advances
- Lymphoma Diagnosis and Treatment
- Esophageal and GI Pathology
- Colorectal Cancer Screening and Detection
- Parkinson's Disease Mechanisms and Treatments
- Reconstructive Facial Surgery Techniques
- Radiomics and Machine Learning in Medical Imaging
- Breast Implant and Reconstruction
- Transcranial Magnetic Stimulation Studies
- Reconstructive Surgery and Microvascular Techniques
- Ferroptosis and cancer prognosis
- Anorectal Disease Treatments and Outcomes
- Cancer therapeutics and mechanisms
- PARP inhibition in cancer therapy
Sixth Affiliated Hospital of Sun Yat-sen University
2019-2024
Sun Yat-sen University
2016-2024
Fujian Medical University
2020-2024
Fujian Provincial Cancer Hospital
2020-2024
Shantou Central Hospital
2020
Fifth Affiliated Hospital of Sun Yat-sen University
2016-2019
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2019
Small cell lung cancer (SCLC), as a proportion, makes up only 15-17% of cases. The development treatments for SCLC has remained stagnant decades, and is expected to persist threat human health. To date, no publications based on large populations have been reported. We calculated survival changes in patients with during each decade between 1983 2012 determine the roles race, sex, age, socioeconomic status (SES) rates Surveillance, Epidemiology, End Results (SEER) registries. In total, 106,296...
The role of programmed cell death ligand 1 (PD-L1) in non-small lung cancer (NSCLC), especially according to histologic type, remains controversial. purpose this study was assess PD-L1 expression and its association with overall survival (OS) clinicopathologic characteristics NSCLC.Formalin-fixed paraffin-embedded specimens were obtained from 108 patients surgically resected primary NSCLC. assessed via immunohistochemistry using a histochemistry score system. relationship between OS or...
Abstract Background SETD2 protects against genomic instability via maintenance of homologous recombination repair (HRR) and mismatch (MMR) in neoplastic cells. However, it remains unclear whether dysfunction is a complementary or independent factor to microsatellite instability-high (MSI-H) tumor mutational burden-high (TMB-H) for immunocheckpoint inhibitor (ICI) treatment, little known regarding this type acts differently various types cancer. Methods This cohort study used multidimensional...
Non–small cell lung cancer is the most common malignancy in males; it constitutes majority of cases and requires massive medical resources. Despite improvements managing non–small cancer, long-term survival remains very low. This study evaluated improvement patients with each decade between 1983 2012 to determine impact race, sex, age, socioeconomic status on rates these patients. We extracted data from Surveillance, Epidemiology, End Results registries. In total, 573,987 were identified 18...
Purpose . The morbidity of esophageal adenocarcinoma (EAC) has significantly increased in Western countries. We aimed to identify trends incidence and survival patients with EAC the recent 30 years then analyzed potential risk factors, including race, sex, age, socioeconomic status (SES). Methods. All data were collected from Surveillance, Epidemiology, End Results or SEER database. Kaplan–Meier analysis Cox proportional hazards model conducted compare differences between variables, SES, as...
Background: Leptomeningeal metastasis (LM) is a fatal complication, and its incidence increasing in non-small cell lung cancer (NSCLC). Refractory LM (rLM) has become problematic due to the lack of uniform definition standardized treatment guidelines. In this study, we assessed efficacy safety multiple therapy based on intrathecal pemetrexed (IP) patients with rLM NSCLC.
Currently, reliable approaches for accurate assessment of lymph node metastases (LNM), which is an important indication preoperative chemoradiotherapy (CRT), are not available clinically node-negative rectal cancer patients. This study aims to identify clinical factors associated with LNM and establish a nomogram prediction in patients.The least absolute shrinkage selection operator (LASSO) aggression multivariate logistic regression analyses were applied LNM. A was established predict the...
Acute pancreatitis complicated with pulmonary embolism has been described in literature, however, hyperlipidaemic acute and deep vein thrombosis rarely reported. We reported here a rare case of pancreatitis. Although he had undergone plasmapheresis his TG level reduced to normal range symptoms relieved, developed multiple thromboses. The patient was diagnosed early successfully salvaged by interventional radiology oral anticoagulants. 51-year-old man, experienced sudden upper abdomen pain...
Immune checkpoint inhibitors (ICIs) have become an important milestone in the treatment of non-small cell lung cancer (NSCLC). High expression protein ligand 1 (PD-L1) and tumor mutation burden (TMB) can help to select dominant population for immunotherapy, but PD-L1 does not seem be unchanged. A 61-year-old man with adenocarcinoma experienced postoperative recurrence. was negative before recurrence, TMB stable by next-generation sequencing (NGS) test. However, after radiotherapy...
Abstract Background Advanced lung adenocarcinoma patients often develop resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs), leaving uncertainties regarding subsequent treatment strategies. Although personalized therapy targeting individual acquired resistances (ARs) shows promise, its efficacy has not been systematically compared with platinum-containing doublet chemotherapy, a widely accepted after EGFR-TKIs failure. Methods A retrospective dual-center study was conducted involving...
Transanal total mesorectal excision has emerged as a potential solution to certain limitations associated with laparoscopic in rectal cancer patients. Differences surgical approaches have raised questions regarding their impact on the risk of postoperative urinary retention, limited data available from large scale randomized clinical study.
e20546 Background: Lung adenosquamous carcinoma (ASC) is an uncommon histological subtype. We aimed to characterize the tumor immune microenvironment (TIME) in lung ASC and estimate patient response checkpoint inhibitors (ICIs), which have never been systematically investigated. Methods: In cohort I, we collected 30 ASCs from a single center for analysis of TIME characteristics, including immuno-phenotyping, mutation burden (TMB), T cell receptor (TCR) repertoires, tumor-infiltrating...
e18533 Background: While the immune checkpoint blockades had demonstrated promising benefits in head and neck cancer (HNSC), its clinical efficacy is limited to a selected subset of less than 20% HNSC patients. Tumor mutation burden (TMB) has been reported as predictor for ICBs multiple tumors, including HNSC. However, association driver genes with TMB outcomes patients not yet established. Methods: Somatic landscape was characterized by interactively analyzed sequencing data 495 samples...
e21082 Background: There were no relative researches referring to optimal treatment strategy after the resistance first/second-generation EGFR-TKIs without T790M mutation or third generation as first second line therapy. Methods: Retrospective analysis was performed on clinical and sequencing data obtained from 129 patients with advanced EGFR-mutant lung adenocarcinoma disease progression prior EGFR-TKIs.The divided into Chemotherapy group Personalized according therapies acquired EGFR-TKIs....