A5101743387- MicroRNA in disease regulation
- Lung Cancer Research Studies
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Seaweed-derived Bioactive Compounds
- Phytochemistry and Biological Activities
- Circular RNAs in diseases
- Chronic Lymphocytic Leukemia Research
- Phytochemicals and Antioxidant Activities
- Chronic Myeloid Leukemia Treatments
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Natural product bioactivities and synthesis
- Nanocluster Synthesis and Applications
- Injection Molding Process and Properties
- Advanced ceramic materials synthesis
- Natural Compounds in Disease Treatment
- Hippo pathway signaling and YAP/TAZ
- PI3K/AKT/mTOR signaling in cancer
- Peptidase Inhibition and Analysis
- Climate Change and Health Impacts
- Marine and coastal plant biology
- Autophagy in Disease and Therapy
- Bone Metabolism and Diseases
Fudan University
2024
Nanjing Drum Tower Hospital
2023
First Hospital of Jilin University
2014-2022
Jilin University
2014-2022
Chinese Academy of Sciences
2022
Dalian Polytechnic University
2020-2021
University of Oklahoma Health Sciences Center
2015
First Bethune Hospital of Jilin University
2014
Jilin Medical University
2011
Tsinghua University
2004
Fucoxanthin (FX), a natural carotenoid found in seaweed with multiple functional activities, is unstable poor water solubility that limits its utilization. This study aimed to improve FX's stability and bioavailability via the nano-encapsulation of FX polyvinylpyrrolidone (PVP)-coated FX@PVP nanoparticles (NPs). The NPs were evaluated terms their morphology, stability, encapsulation efficiency (EE), loading capacity (LC), vitro release optimize parameters, 1:8 FX:PVP ratio was perform best...
Profiling of polyphenolics in four types brown macroalgae, namely Laminaria japonica (L. japonica), Undaria pinnatifida (U. pinnatifida), Sargassum fusiforme (S. fusiforme), and Ascophyllum nodosum (A. nodosum), their effect on oxidation resistance were investigated for the first time. Polyphenolic extracts from marine macroalgae shown to effectively remove oxidants cells cellular systems. A. showed highest antioxidant activity among evaluated showing a better scavenging...
Abstract Epidemiological studies show that particulate matter (PM) with an aerodynamic diameter ≤ 2.5 μm (PM2.5) is associated cardiorespiratory diseases via the induction of excessive oxidative stress. However, precise mechanism underlying PM2.5‐mediated stress injury has not been fully elucidated. Accumulating evidence indicated microRNA let‐7 family might play a role in PM‐mediated pathological processes. In this study, we investigated let‐7a and cell human bronchial epithelial BEAS2B...
Osteogenesis from preosteoblasts is important for bone tissue engineering. MicroRNAs are a class of endogenous small RNA molecules that potentially modulate osteogenesis. In this study, we found miR-155 expression was downregulated in time-dependent manner cells the preosteoblast cell line MC3T3-E1 after osteogenic induction using morphogenetic protein 2 (BMP2). Transfection with decreased alkaline phosphatase (ALP) activity, ALP expression, and staining intensity Alizarin Red treated BMP2,...
Microglia-mediated neuroinflammation is involved in various neurological diseases, including ischemic stroke, but the endogenous mechanisms preventing unstrained inflammation still unclear. The anti-inflammatory role of transcription factor nuclear receptor subfamily 4 group A member 1 (NR4A1) macrophages and microglia has previously been identified. However, that how NR4A1 restricts remain elusive. Here, we observed up-regulated cytoplasm activated localizes to processing bodies (P-bodies)....
Lung carcinoma is a deadly malignant disease with poor prognosis and increasing incidence in recent years. However, the molecular mechanism underlying initiation progression of lung cancer still not completely elucidated. Recently, myocyte enhancer factor 2D (MEF2D) has been reported to promote growth liver cancer, but its implication unknown. This study aimed determine role MEF2D carcinoma. Quantitative PCR (qPCR) immunoblot assays showed that was overexpressed tissues cell lines, compared...
Purpose: CD4+CD25+Foxp3+ regulatory T (Treg) cell-mediated immunosuppression has been implicated as a crucial mechanism of tumor immune cell escape in nonsmall lung cancer (NSCLC). However, little is known concerning the specific role CD4+CD25-Foxp3+ Treg cells NSCLC. The aim this study was to investigate frequency circulating and their Methods: frequencies Treg, helper (Th)1, Th2, Th17 peripheral blood were separately measured 36 NSCLC patients 20 healthy controls (HCs) using flow...
Transforming growth factor-beta (TGF-β) type II receptor (TβRII) levels are extremely low in the brain tissue of patients with Alzheimer's disease. This inhibits TGF-β1/SMAD signaling and thereby aggravates amyolid-beta deposition neuronal injury. Dab2, a specific adapter protein, protects TβRII from degradation ensures effective conduction signaling. In this study, we used an adenoviral vector to overexpress Dab2 gene mouse hippocampus investigated regulatory effect protein on model...
Diselenide-containing paclitaxel nanoparticles (SePTX NPs) indicated selectivity of cytotoxicity between cancerous and normal cells in our previous work.Herein, the mechanism is revealed by molecular biology detail.Cancer were treated with SePTX NPs cell proliferation was measured using 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolium bromide (MTT) assay morphology.Measurement reactive oxygen species (ROS) levels biochemical parameters employed to monitor oxidative stress...
Phlorotannins are a group of major polyphenol secondary metabolites found only in brown algae and known for their bioactivities multiple health benefits. However, they can be oxidized due to external factors bioavailability is low water solubility. In this study, the potential utilizing nanoencapsulation with polyvinylpyrrolidone (PVP) improve various activities phlorotannins was explored. encapsulated by PVP nanoparticles (PPNPS) different loading ratios were prepared characterization....
Single crystal superalloy hollow blade is an important part of aero-engine, and its inner cavity structure prepared by ceramic core.With the increase thrust-weight ratio core more complex.Traditional preparation technology difficult to meet requirements complex preparation.Stereolithography 3D printing cores provides a feasible scheme for cores.In
Oxidative stress or the production of reactive oxygen species (ROS) has been implicated as an important factor in development bleomycin (BLM)-induced pulmonary toxicity; however, mechanism behind toxicity remains to be elucidated. The present study aimed investigate key involved BLM‑induced toxicity. was conducted human fibroblast (HPF) cells and a mouse model. ROS level, cell death assay, protein gene expression levels Kruppel‑like 9 (Klf9) other associated factors were assessed. A...
Although curcumin (CUR) has many advantages, its hydrophobicity and instability limit application. In this study, the anti-lipotoxic injury activity of CUR-loaded nanoparticles (CUR-NPs) corresponding mechanism were examined in palmitate (PA)-treated cardiomyocytes. An amphiphilic copolymer was selected as vehicle material, CUR-NPs with suitable sizes prepared under optimized conditions. Cellular uptake by confocal laser scanning microscopy, cell proliferation inhibition rate measured using...
A simple and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of isoquercitrin, kaempferol-3-O-rutinoside tiliroside in rat plasma. Plasma samples were deproteinized with methanol separated on a Hypersil Gold C18 column (2.1 × 50 mm, i.d., 3.0 μm) using gradient elution mobile phase water at flow rate 0.4 mL/min. Mass spectrometric detection performed negative ion electrospray ionization selected reaction monitoring...
Oxidized phlorotannin can be used as a protein crosslinking agent to produce high-quality fish gel products. Phlorotannin easily induced form quinone compounds in an oxidizing environment, while o-quinone has been proven reactive, electrophilic intermediate that reacts with proteins rigid molecular networks. The objective of this study was investigate the synergistic effects ultraviolet A (UVA) irradiation (1 h, 15 W m
New Findings • What is the central question of this study? Does miR-124 affect cell proliferation and apoptosis in acute liver failure (ALF) mice? main finding its importance? Inhibiting targets PIM-3 thus upregulates expression, consequently inhibiting promoting proliferation, ultimately preventing progression ALF. This highlights a promising competitive new target for ALF treatment. Abstract Acute complicated syndrome frequently leading to dysfunction various organs. MicroRNAs (miRNAs)...
OBJECTIVE To investigate the mechanism of apoptosis chronic myeloid leukemia (CML) cells induced by novel p210 bcr/abl inhibitor berbamine. METHODS Human Ph+ CML K562 cells, which express endogenous protein, were cultured in RPMI 1640 and treated with berbamine as indicated time dose. Flow cytometry (FCM) Annexin-V-Fluos/PI staining kit used to evaluate leukemic cells; FCM cytoperm/cytofix plus Caspase-3-McAb-PE employed measure activated Caspase-3. Phosphorylation protein assessed a...
Abstract Farrerol is a 2,3‐dihydro‐flavonoid isolated from rhododendron. In this study, sensitive and selective ultra‐high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method was developed for the determination of farrerol in rat plasma. Liquid–liquid extraction by ethyl ether used sample preparation. Chromatographic separation achieved on an Agilent UHPLC XDB‐C 18 column (2.1 × 100 mm, 1.8 μm) with water methanol (30:70, v /v) as mobile phase. An electrospray...