A5100721788- Macrophage Migration Inhibitory Factor
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Ovarian cancer diagnosis and treatment
- CAR-T cell therapy research
- Nuclear Receptors and Signaling
- Genetic factors in colorectal cancer
- Nanoparticle-Based Drug Delivery
- Lung Cancer Treatments and Mutations
- Nanoplatforms for cancer theranostics
- Colorectal Cancer Treatments and Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Medical Image Segmentation Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Angiogenesis and VEGF in Cancer
- Pleural and Pulmonary Diseases
- Cell Adhesion Molecules Research
Chinese People's Liberation Army
2016-2025
Anhui Mental Health Center
2024-2025
Air Force Medical University
2025
Chinese PLA General Hospital
2024
PLA Academy of Military Science
2024
Anhui Medical University
2023-2024
Fourth Affiliated Hospital of Anhui Medical University
2024
Zhongshan Hospital
2023
Fudan University
2023
China Medical University
2022
Melanomas harbor aberrations in the c-Kit gene. We tested efficiency of tyrosine kinase inhibitor imatinib selected patients with metastatic melanoma harboring mutations or amplifications.Forty-three were enrolled on this phase II trial. Each patient received a continuous dose 400 mg/d unless intolerable toxicities disease progression occurred. Fifteen who experienced allowed to escalate 800 mg/d.Forty-three eligible for evaluation, and median follow-up time was 12.0 months. The...
Objective The initial colonisation of the human microbiota and impact maternal health on neonatal at birth remain largely unknown. aim our study is to investigate possible dysbiosis associated with gestational diabetes mellitus (GDM) estimate potential risks microbial shift neonates. Design Pregnant women neonates suffering from GDM were enrolled 581 (oral, intestinal vaginal) 248 pharyngeal, meconium amniotic fluid) samples collected. To avoid vaginal bacteria contaminations, included...
Astrocytes act as immune effector cells with the ability to produce a wide array of chemokines and cytokines in response various stimuli. Macrophage migration inhibitory factor (MIF) is inducibly expressed injured spinal cord contributing excessive inflammation that affects motor functional recovery. Unknown whether MIF can facilitate inflammatory responses through stimulating release from astrocytes following injury.Following establishment contusion injury rat model, correlation chemokine...
Astrocytes have been shown to produce several pro- and anti-inflammatory cytokines maintain homeostasis of microenvironment in response vast array CNS insults. Some inflammation-related are responsible for regulating such cell events. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that can be inducibly expressed the lesioned spinal cord. Unknown whether MIF facilitate production immunosuppressive factors from astrocytes tune milieu following cord injury. Following...
The limited anticancer drug library and the frequent occurrence of resistance have driven monotherapy-based cancer therapy into a difficult situation. Considering formidable process new discovery, combination using currently available drugs is potential alternative. Nevertheless, barrier between in vitro screening precise vivo delivery remains insurmountable current free-drug- or nanoparticle (NP)-based therapy, which substantially hinders application therapy. Herein, novel, strategy to...
TP53 has been proved to be associated with cytotoxic T-cell induced apoptosis, however, the association between and benefit of immunotherapy in melanoma not studied. In present study, we examined relationship mutation response CTLA-4 blockade metastatic by analyzing data from one public cohort consisting 110 patients melanoma. The sequencing, mRNA survival 368 skin Cancer Genome Atlas (TCGA) was used explore underlying mechanism. significant poorer progression-free (HR, 2.25; 95% CI,...
Background: Kirsten rat sarcoma vial oncogene (KRAS) is one of the most prevalent oncogenes in multiple cancer types, but incidence different between Asian and non-Asian populations. The recent development KRAS G12C targeting drug has shown great promise. It thus important to understand genomic landscape a specific population. Methods: Sequencing data 11,951 tumor samples collected from 11/2016 7/2019 centres China were analyzed for mutation status. Concomitant aberrations further tumors...
More and more evidence shows that infection immune abnormality are closely related to the increased severity of schizophrenia symptoms. This study aimed explore correlation between inflammatory cell counts, sleep quality, psychiatric symptoms in first-episode patients. A total 103 patients (patient group) admitted Anhui Provincial Mental Health Center from November 2021 August 2022 were included study, while 57 healthy individuals (control who met criteria recruited as subjects. The Positive...
Glioma is a major cause of mortality among central nervous system tumors, with generally poor prognosis. The lysyl oxidase (LOX) family, group copper-dependent amine oxidases, has been implicated in the progression various cancers, but its specific role glioma and relationship immune infiltration remains insufficiently explored. This study aims to investigate LOX family's expression, prognostic significance, dynamics identify potential therapeutic targets. A comprehensive analysis was...
Integrin, beta-like 1 (ITGBL1), a β-integrin-related extracellular matrix protein, was found more commonly up-regulated in gastric cancer (GC) by screening and analyzing Gene Expression Omnibus (GEO) Oncomine databases, reminding us to explore its prognostic significance GC. In our current study, we observed that ITGBL1 expression significantly GC compared with normal controls clinical specimens. addition, elevated positively correlated patients' tumor-node-metastasis (TNM) stage distant...
This retrospective analysis evaluated the mechanism of bevacizumab plus chemotherapy (BV+CT) for preventing brain metastasis derived from lung cancer. From total 159 patients with advanced non-small cell cancer (NSCLC), 110 received BV+CT and 49 CT. After medication, both groups had 15 metastases (14 vs 31%, P < 0.05). With treatment, 40 (33.89%) survived, whereas only 11 (18.64%) survived CT treatment. The outcome group was significantly better than that vascular endothelial growth factor...
Well-defined water-soluble block copolymers poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide-co-N-methacryloylglycylglycine) (PEG-b-P(HPMA-co-MAGG)) and their doxorubicin (Dox) conjugates with different composition molecular weight were synthesized. These Dox can form micelles in buffer solution. The physicochemical properties, vivo biodistribution, blood clearance, especially the tumor accumulation of studied. Severe liver be observed for PEG-b-PMAGG copolymers. This was...
The objectives of the study are to observe and analyze causes 237 patients' malposition peripherally inserted central catheter ( PICC ) from 3012 patients in clinical practice further explore methods its prevention remedies, which can help improve skills placing tubes, efficiently avoid reduce occurrence complications, alleviate pains cost patients. From A ugust 2000 M arch 2012, cases receiving were reviewed. locations tube tips recorded by chest X ray summarized for analysis. Malposition...
Hepatocellular carcinoma (HCC) remains one of the most common cancers worldwide. HSPA2 has been highlighted as an important marker in many types cancers. However, little is known about role HCC. The objective current study was to investigate expression pattern and clinicopathological significance patients with Quantitative reverse-transcriptase ploymerase chain reaction (qRT-PCR) applied examine messenger RNA (mRNA) 52 pairs HCC tissues adjacent noncancerous tissues. Immunohistochemistry...
Background: Schizophrenia (SCZ) is a severe mental illness, Cognitive deficits and negative symptoms (NS) are prevalent in individuals with SCZ crucial indicators of functional recovery. It well known that cognitive interrelated can affect the ability to take tests. However, specific relationship between attention, working memory (WM), NS stable remains unclear. This study aims explore these associations provide valuable insights for subsequent treatment SCZ. Methods: We conducted...
Oxaliplatin (L-OHP) is standard treatment for colorectal cancer. However, resistance to L-OHP often leads failure or cancer relapse. Understanding of the mechanism underlying important overcome and improve treatment. This study aimed identify new proteins that mediates in elucidate their mode function. HT-29 cells were exposed gradually increased concentration select resistant HT-29/L-OHP cell line. Proteomic analysis performed differentially expressed proteins, including Poly(C)-binding...
Cholangiocarcinoma (CC) is one of the fatal malignant neoplasms with poor prognosis. The traditional chemotherapy has been resistant to CC and does not improve quality life. aim present study investigate potential chondroitin sulphate (CS)-histamine (HS) block copolymer micelles chemotherapeutic efficacy docetaxel (DTX).
Abstract SOCS3, a feedback inhibitor of the JAK/STAT signal pathway, negatively regulates axonal regrowth and inflammation in central nervous system (CNS). Here, we demonstrated distinct role SOCS3 injured spinal cord gecko following tail amputation. Severing did not evoke an inflammatory cascade except for injury-stimulated elevation granulocyte/macrophage colony-stimulating factor (GM-CSF) interferon gamma (IFN-γ) cytokines. Simultaneously, expression was upregulated microglia,...
We have previously shown that childhood-onset rheumatic diseases show aberrant patterns of gene expression reflect pathology-associated co-expression networks. In this study, we used novel computational approaches to examine how disease-associated networks are altered in one the most common childhood, juvenile idiopathic arthritis (JIA). Using whole blood profiles derived from children a pediatric rheumatology clinical trial, network approach understanding impact therapy and underlying...