A5110797933- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Horticultural and Viticultural Research
- Peptidase Inhibition and Analysis
- Fermentation and Sensory Analysis
- Lung Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Chromatin Remodeling and Cancer
- Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Cancer Immunotherapy and Biomarkers
- Phytochemicals and Antioxidant Activities
- CRISPR and Genetic Engineering
- Asthma and respiratory diseases
- Synthesis and biological activity
- Sarcoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Melanoma and MAPK Pathways
- Pain Management and Opioid Use
- Plant biochemistry and biosynthesis
- Histone Deacetylase Inhibitors Research
Fourth Hospital of Hebei Medical University
2017-2024
Hebei Medical University
2017-2024
Shanxi Academy of Medical Sciences
2022-2023
Shanxi Medical University
2023
Background: Kirsten rat sarcoma vial oncogene (KRAS) is one of the most prevalent oncogenes in multiple cancer types, but incidence different between Asian and non-Asian populations. The recent development KRAS G12C targeting drug has shown great promise. It thus important to understand genomic landscape a specific population. Methods: Sequencing data 11,951 tumor samples collected from 11/2016 7/2019 centres China were analyzed for mutation status. Concomitant aberrations further tumors...
Abstract Breast cancer represents a significant health burden globally, necessitating ongoing advancements in treatment strategies for improved patient outcomes. Immunotherapy, particularly targeting immune checkpoints like programmed death‐1 (PD‐1), has emerged as promising approach therapy. This study focuses on elucidating the role of PD‐1 modulating IFN‐γ‐CXCL9/10‐CXCR3 signaling axis within breast microenvironment. By investigating synergistic effects inhibitors combination with...
Recent studies have shown that long non-coding RNAs (lncRNAs) are involved in a variety of biological processes and diseases humans, including cancer. However, the exact effects molecular mechanisms TP73-AS1 non-small cell lung cancer (NSCLC) progression still unknown. The present study is aimed to reveal detailed functions mechanism regulation NSCLC proliferation.TP73-AS1 expression tissues lines was determined using real-time PCR assays. proliferation evaluated BrdU interaction between...
The Bohai Bay region is a famous wine-growing area in China, where the rainfall concentrated summer due to influence of temperate semi-humid monsoon climate. As such, vineyard terrain has significant impact on flavor quality grapes and resulting wines. To explore relationship between 'Cabernet Sauvignon' wine style terrain, this study takes four different plots Jieshi Mountain investigate differences aroma profile Cabernet Sauvignon wines two consecutive vintages. Based two-way ANOVA, there...
BACKGROUND: Lung adenocarcinoma is the most common type of lung cancer, and it one aggressive rapidly fatal tumor types. OBJECTIVE: To identify a signature mutation genes for prognostic prediction adenocarcinoma. METHODS: Four hundred sixty-two cas es were screened out downloaded from TCGA database. Mutation data 18 targeted detected by MuTect. LASSO-COX model was used to screen gene loci, then prognosis established. Afterwards, 40 clinical patients collected verify features predictive...
e16678 Background: Biliary tract cancers (BTCs) are a group of relatively rare invasive carcinomas including gallbladder carcinoma (GBC), intrahepatic (ICC), hilar (HCCA), and extrahepatic (ECC) cholangiocarcinoma. In the ROAR basket trial, dabrafenib, BRAF inhibitor, combined with trametinib, MEK demonstrated promising efficacy in patients BTCs an overall response rate (ORR) 41% favorable safety profile. The frequency mutations reported BTC varies widely, V600E have been 0% to 20% BTCs....
Human esophageal cancer (hESC) cell motility adopts various modes, resulting in hESC progression and poor survival. However, how tripartite motif 59 (TRIM59), as the ubiquitination machinery, participates metastasis is not completely understood. The results indicated that TRIM59 was aberrantly upregulated tissues compared with adjacent healthy tissues, which associated survival advanced TNM state among patients hESC. Moreover, higher expression displayed undetectable p53 expression,...
This study investigated the effect of leaf removal at three stages grape development on phenolic and volatile profiles Cabernet Sauvignon Marselan grapevines for two consecutive years in Jieshi Mountain region, an area eastern China with high summer rainfall. The results indicated that cluster-zone generally reduced titratable acidity both varieties, but did not affect total soluble solids berries. Leaf-removal treatments increased anthocyanin flavonol content berries varieties. However,...
What is the central question of this study? How does miR-302a-3p play a role in hypoxia-reoxygenation-induced pyroptosis renal tubular epithelial cells? main finding and its importance? Hypoxia-reoxygenation treatment upregulated expression HK-2 cells, then inhibited transcription FMRP translational regulator 1 (FMR1), so as to promote activation NLRP3 inflammasome aggravate cells. was used molecular target study, which provides new theoretical basis for failure.Hypoxia-reoxygenation (H/R)...
The application of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs) in non-small cell lung cancer (NSCLC) may be affected by somatic mutations. purpose this study was to explore the effect mutations on prognosis and tumor markers NSCLC patients treated with EGFR-TKIs. 21 EGFR-TKIs were selected, targeted sequencing tissues or whole blood samples 1000-gene panel conducted screen Afterward, functional enrichment analysis performed based mutant genes. Subsequently,...
The role of PM2.5 in the bronchial asthma remains unclear. In this study, deficient mice TLR4-/-, TLR2-/- and MyD88 -/- were used to establish model. effects on inflammatory response lung tissue these observed. increased alveolar macrophages neutrophils, up-regulated IL-12 KC expression WT mice, but down-regulated their levels TLR2 -/-, TLR4 mice. OVA+PM2.5 stimulated neutrophil count it decreased also Eotaxin, IL-5, IL-13 MCP-3 levels, OVA specific IgE IgG1 serum group. may activate NF-κB...
The association between malignant tumors and the occurrence of glomerular disease has been well documented in previous studies. most common types tumor include Hodgkin's lymphoma with minimal change nephritis, solid membranous nephropathy renal cell carcinoma immunoglobulin (Ig)A nephropathy. present case study describes a 31-year-old Chinese female patient who was hospitalized chronic glomerulonephritis. self-administered unknown traditional medicine; however, protein excretion/24-h...
Background MicroRNAs (miRNAs) are non-coding small molecule RNAs that widely found in eukaryotic organisms, although some miRNAs have been tumors, the expression and effects of miR-665 on cell lung cancer (SCLC) unclear. The aim this study was to analyze proliferation, cycle, invasion migration SCLC cells, explore role its working mechanism. Methods tissues adjacent normal detected by qRT-PCR. TargetScan predicted potential target genes for validated with dual luciferase reporter assays,...
e23528 Background: The rarity and heterogeneity of sarcoma has been complicating the diagnosis for years. Even expert pathologists could make mistakes in this disease. availability Next Generation Sequencing (NGS) data enabled more accurate sarcoma. In study, we systematically described application NGS on contribution to diagnostic accuracy Methods: A multi-center, retrospective study included 235 patients’ tumor paired normal samples that were sent from 56 hospitals a College American...
e21046 Background: To explore the prognostic value of TP53 co-mutation with EGFR or KRAS in advanced non-small cell lung cancer. Methods: 314 patients cancer (NSCLC) admitted to Department Oncology Fourth Hospital Hebei Medical University from January 2016 2021 were retrospectively analyzed, all complete genetic information.According analysis results, and identified as co-mutated genes.TP53 mutation was used experimental group wild control group.Patients further classified discussed...
e21086 Background: To compare the prognoses of EGFR complex mutation, co-mutation and single mutation with first-line TKI treatment in NSCLC patients. Methods: A retrospective study 215 patients EGFR-mutated who were admitted to Department Medical Oncology, Fourth Hospital Hebei University from January 2015 2021, all received EGFR-TKI therapy. According type they divided into 48 cases (22.3%) group, 142 (66.0%) which 23 (10.6%) both had co-mutation. The latter two groups compared that group...
e15639 Background: To explore the efficacy and safety of pyrotinib in treatment HER-2 positive advanced solid tumors patients. Methods: Patients with oncology department our hospital from October 2018 to Janurary 2020 were collected. All patients given oral 400mg once a day 28-day cycle. The clinicopathological characteristics, history, curative effect collected, adverse reactions related recorded. Results: 13 enrolled, including 11 metastatic breast cancer, 3 colon gastric cancer. Among...
Abstract Background: Cancer immunotherapy, especially immune checkpoint inhibitors (ICIs), is remarkably effective in non-small cell lung cancer (NSCLC), but only a small number of patients can derive durable benefits from it. Therefore, more accurate biomarkers are highly needed. The inactivation subunits the Switch/Sucrose Non-Fermentable (SWI/SNF) complex was associated with long lasting responses to ICIs clear renal carcinoma and soft tissue sarcoma. Although genomic alterations (GAs)...
Hereditary breast cancer is an autosomal dominant syndrome caused by germ-line mutations in the human genes, BRCA1 and BRCA2. Mutations either or BRCA2 are major causes of familial early-onset cancer. The present study investigated a 33-year-old Chinese female patient with using targeted next generation sequencing. A novel heterozygous deletion-insertion was also identified gene, c.311_312delinsAGGTTTGCA, which formation truncated protein 109 amino acids instead wild-type 1,863 acids. These...
Nivolumab has been used in a variety of advanced malignant tumors. Cases autoimmune diabetes associated with therapy have reported gradually recent years. This article case primary testicular lymphoma an elderly patient type 2 mellitus (T2DM). After treatment Nivolumab, the disease was hyperprogressive but blood glucose relieved for long time. may relieve previous T2DM diffuse large B-cell patients; potential mechanism needs to be further explored.
The aim of this study is to analyze the distribution characteristics specific allergens based on immunoglobulin E (IgE) test, performed using sera patients with allergic diseases in Shanxi region China. Sera from 3141 were analyzed immunoblotting for IgE antibodies inhaled and ingested allergens. association factors such as disease profile, sex, age, cosensitization who tested positive analyzed. most common rate was mugwort, followed by dust mite mix ragweed. crab, egg white sea fish mix....