A5061194998- Intermetallics and Advanced Alloy Properties
- Prion Diseases and Protein Misfolding
- Dementia and Cognitive Impairment Research
- Semiconductor materials and interfaces
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Genetic Mapping and Diversity in Plants and Animals
- MXene and MAX Phase Materials
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Advanced ceramic materials synthesis
- Amyotrophic Lateral Sclerosis Research
- Genetic Neurodegenerative Diseases
- Crystallization and Solubility Studies
- Neurological diseases and metabolism
- GABA and Rice Research
- X-ray Diffraction in Crystallography
- Sleep and Wakefulness Research
- Neuropeptides and Animal Physiology
- Advanced Chemical Physics Studies
- Advanced Neuroimaging Techniques and Applications
- Rice Cultivation and Yield Improvement
- nanoparticles nucleation surface interactions
- Natural Language Processing Techniques
Capital Medical University
2013-2025
Nanjing University
2024-2025
Nanjing University of Chinese Medicine
2024-2025
Nanjing Drum Tower Hospital
2024-2025
Jiangxi University of Traditional Chinese Medicine
2025
Hebei University of Science and Technology
2024
Air Force Medical University
2021-2024
Capital University
2022-2024
Chinese Academy of Sciences
2003-2023
University of Chinese Academy of Sciences
2023
The heterotrimeric G protein complex, consisting of Gα, Gβ, and Gγ subunits, are conserved signal transduction mechanism in eukaryotes. Recent molecular researches had demonstrated that signaling participates the regulation yield related traits. However, effects genes on components stress tolerance not well characterized.In this study, we generated mutants rice using CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats) gene-editing technology. proteins were investigated....
Clinical studies found that regular aerobic exercise has analgesic and antianxiety effects; however, the underlying neural mechanisms remain unclear. Multiple have suggested may exert brain-protective effects by promoting release of serotonin, which be a pain modulator. Anterior cingulate cortex (ACC) is key brain area for information processing, receiving dense serotonergic innervation. As result, we hypothesized increase serotonin in ACC, thus improving anxiety behaviors.Integrative...
Background:The Mild Behavioral Impairment Checklist (MBI-C), a screening scale for neuropsychiatric symptom evaluation, facilitates Alzheimer's disease (AD) screening. However, its validity and reliability use as an AD tool have not been determined. Objective:To develop screenin g suitable the Chinese population. Methods:The MBI-C was translated into back-translated with original author's consent. Forty-six patients, attending Xuanwu hospital memory clinic, 50 sex- education-matched controls...
Two addition orders, i.e., the layer-by-layer (L) and mixed biopolymer (M) were used to generate sodium caseinate - sugar beet pectin electrostatically stabilized o/w emulsions with 0.5% oil varying caseinate: ratios (3:1-1:3) at pH 4.5. Emulsion stability against environmental stresses (i.e., pH, salt addition, thermal treatment, storage
Background and purpose Migraine is a complex disabling neurological disorder, the exact mechanisms of which remain unclear. The thalamus considered to be hub central processing integration nociceptive information, as well modulation these processes. Methods A total 48 migraineurs without aura (MWoAs) during interictal phase age‐ sex‐matched healthy controls underwent resting‐state functional magnetic resonance imaging scans. We utilized masked independent component analysis seed‐based...
Bone cancer pain (BCP) is one of the most severe complications in patients. However, pharmacological therapeutic approaches are limited. Luteolin, a major component flavones, widely distributed plants and plays critical role antinociceptive effects, but whether luteolin could alleviate its underlying mechanisms not known.This study investigated molecular by which reduced BCP.Behavioral, pharmacological, immunohistochemical, biochemical were used to investigate effect on BCP.Luteolin...
Abstract Background A mobile cognition scale for community screening in cognitive impairment with rigorous validation is paucity. We aimed to develop a digital that overcame low education mild (MCI) due Alzheimer’s disease (AD) and AD. Methods self-assessment (CogSAS) was designed through the Delphi process, which feasible older population education. In Phase 1, 518 clinically diagnosed participants were subjected optimise items. 2, validated 358 cognitively unimpaired 396 of MCI dementia...
Significance: Damage after stroke is not only limited to the brain but also often occurs in remote organs, including heart, lung, liver, kidney, digestive tract, and spleen, which are frequently affected by complex pathophysiological changes. The organs human body closely connected, signals transmitted through various molecular substances could regulate changes of organs. Recent Advances: latest studies have shown that inflammatory response plays an important role organ damage stroke, can...
Vision-based 3D occupancy prediction has become a popular research task due to its versatility and affordability. Nowadays, conventional methods usually project the image-based vision features space learn geometric information through attention mechanism, enabling semantic prediction. However, these works face two main challenges: 1) Limited information. Due lack of in image itself, it is challenging directly predict information, especially large-scale outdoor scenes. 2) Local restricted...
Abstract Addiction‐related behaviors, such as conditioned place preference (CPP), require animals to remember an association between environmental cue and drug treatment, exposure is one of the key contributing factors relapse. However, how central neural circuit participates in formation CPP induced by stimulus morphine‐paired environment remains unknown. In present study, we found that reexposure significantly increased activity hippocampal CA3 neurons, excitability GABAergic neurons...
Low back pain (LBP) is a leading cause of global disabilities. Numerous molecular, cellular, and anatomical factors are implicated in LBP. Current issues regarding neurologic alterations LBP have focused on the reorganization peripheral nerve spinal cord, but neural mechanisms exactly what impacts brain required further researches. Based existing clinical studies that chronic problems were accompanying structures functions, researchers proposed logical conjectures similar occur patients as...
Objective Elucidate the core clinical and genetic characteristics identify phenotypic variation between different regions genotypes of fatal familial insomnia (FFI). Methods A worldwide large sample FFI patients from our case series literature review diagnosed by testing were collected. The prevalence symptoms profile obtained, then comparison Asians versus non-Asians 129Met/Met 129Met/Val conducted. Results In total, 131 cases identified. age onset was 47.51±12.53 (range 17–76) years, 106...
Abstract Background Behavioral variant frontotemporal dementia (bvFTD) is predominantly considered a dysfunction in cortico-cortical transmission, with limited direct investigation of cortical-subcortical transmission. Thus, we aimed to characterize the metabolic connectivity between areas limbic cortico-striato-thalamic-cortical (CSTC) circuit presymptomatic and symptomatic bvFTD patients. Methods Thirty-three patients 33 unrelated healthy controls were recruited for this study....