A5027175185- Dementia and Cognitive Impairment Research
- Drug-Induced Hepatotoxicity and Protection
- Health disparities and outcomes
- Treatment of Major Depression
- Tryptophan and brain disorders
- Health, Environment, Cognitive Aging
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Nutritional Studies and Diet
- Frailty in Older Adults
- Liver Disease Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Pharmacogenetics and Drug Metabolism
- Aging and Gerontology Research
- Nutrition and Health in Aging
- Drug Transport and Resistance Mechanisms
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Treatment and Access
- Air Quality and Health Impacts
- Sleep and related disorders
- Attention Deficit Hyperactivity Disorder
- Maternal Mental Health During Pregnancy and Postpartum
- Climate Change and Health Impacts
- Cardiac Health and Mental Health
Peking University
2016-2025
Peking University Sixth Hospital
2016-2025
Xinjiang University
2024-2025
Jiaxing University
2025
Guizhou Provincial People's Hospital
2024
National Clinical Research
2015-2022
UNSW Sydney
2021
Duke University
2021
University College London
2021
Cornell University
2021
Whether cognitive decline is related to a higher risk of death independent the initial function inconclusive. Evidence association between and mortality among Chinese older people limited. We aimed examine whether decline, assessed by rate decrease in Mini-Mental State Examination (MMSE) score, was associated with (baseline MMSE score) people. established two successive non-overlapping cohorts adults nested within Longitudinal Healthy Longevity Survey (CLHLS), an ongoing, open,...
Air pollution might accelerate cognitive ageing; it is unclear whether large-scale interventions, such as China's Clean Act (CCAA), can mitigate deterioration. We aimed to evaluate the effect of CCAA on changes in function older adults.In this population-based, quasi-experimental study, we did a difference-in-differences analysis data collected during 2014 and 2018 waves Chinese Longitudinal Healthy Longevity Survey (CLHLS). The study design used counterfactual feature by dividing CLHLS...
Background Anti-tuberculosis drug induced liver injury (ATLI) is emerging as a significant threat to tuberculosis control in China, though limited data available about the burden of ATLI at population level. This study aimed estimate incidence ATLI, better understand its clinical features, and evaluate impact on anti-tuberculosis (TB) treatment China. Methodology/Principal Findings In population-based prospective study, we monitored 4,304 TB patients receiving directly observed strategy...
Background More than 1 million tuberculosis (TB) patients are receiving directly observed treatment strategy (DOTS) therapy in China every year. As to the profile of adverse drug reactions (ADRs) due DOTS therapy, no consensus has been reached. There is report regarding ADRs with a large Chinese TB population. This study aimed determine incidence and prognosis evaluate their impact on anti-TB China. Methods A prospective population-based cohort was performed during 2007–2008. Sputum smear...
to examine a 16-year trend in cognitive impairment (CI) incidence and associated factors among older Chinese people.aged 60 above whose function were normal at their first test.a secondary analysis that identified subjects from the database of Longitudinal Healthy Longevity Survey (CLHLS). The contained mixed longitudinal cohorts people surveyed 1998, 2000, 2002, 2005, 2008-09, 2011-12 2014. was tested using Mini-Mental State Examination (CMMSE) each wave. unique individual code cohort...
Abstract Objective The objectives of this study were to investigate whether the plasma levels oligomeric amyloid-β (OAβ) affected in Alzheimer’s disease (AD) and examine associations (or possible correlations) between OAβ memory performance. Method Thirty subjects with AD 28 cognitively normal controls recruited study. multimer detection system (MDS) was used measure plasma. In addition assessing general cognitive function Mini-Mental State Examination (MMSE), Cognitive Abilities Screening...
Delay in seeking diagnosis of dementia is common China. Misinformation and poor knowledge about may contribute to it. The study was designed explore the nationwide literacy among older adults urban China investigate factors associated with overall literacy.In a cross-sectional study, convenience sample 3,439 community-dwelling old aged 60 over recruited from 34 cities 20 provinces between June August 20, 2014. All participants were administered face-to-face mental health questionnaire, which...
ABSTRACT Background: Cognitive decline in advanced age is closely related to dementia. The trajectory of cognitive function older Chinese yet be fully investigated. We aimed investigate the trajectories a nationally representative sample people living China and explore potential determinants these trajectories. Methods: This study included 2,038 cognitively healthy persons aged 65–104 years at their first observation Longitudinal Healthy Longevity Survey from 2002 2014. was measured using...
Background: Frailty is an epidemic age-related syndrome addressing heavy burden to the healthcare system. Subject rarity, age-, and gender-specific prevalence of frailty its prognosis among longevous population remains under-investigated. Methods: Based on Chinese Longitudinal Healthy Longevity Study (CLHLS, 2008–2018), individuals aged ≥ 65 years having complete data were recruited. Modified Fried criteria (exhaustion, shrink, weakness, low mobility, inactivity) adopted define pre-frailty...
Abstract Objectives To examine sex differences in the cognitive trajectories of a nationally representative sample older people living China and to explore potential determinants these trajectories. Methods The study included 2230 women 2171 men who were cognitively healthy aged over 60 at first observation from Chinese Longitudinal Healthy Longevity Survey based on 2008–2018 cohort. Cognitive function was measured using version Mini‐Mental State Examination (MMSE). Group‐based trajectory...
What is Known and Objective: The pathogenic mechanism of antituberculosis drug-induced hepatotoxicity (ATDH) thought to involve drug-metabolizing enzymes including N-acetyl transferase2 (NAT2), cytochrome P4502E1 (CYP2E1) glutathione S-transferase (GST) M1, T1. associations between genetic polymorphisms those genes ATDH have been reported but with inconsistent results. Moreover, most studies were hospital-based retrospective not prospective. We aimed investigate possible CYP2E1, GSTM1 GSTT1...
Background. Anti-tuberculosis drug-induced hepatotoxicity (ATDH) is one of the most prevalent and serious adverse drug reactions in course anti-tuberculosis (TB) treatment. Some researchers suggested that determination N-acetyltransferase 2 (NAT2) genotype may be clinically useful to identify patients at high risk developing ATDH. Aim. To evaluate whether NAT2 could as a predictor for ATDH Chinese community TB population. Material methods. A total 4304 community-based were followed up six...
The prevalence and factors associated with delays in help seeking for people dementia China are unknown.Within 1,010 consecutively registered participants the Clinical Pathway Alzheimer's Disease (CPAD) study (NCT01779310), 576 persons (PWDs) their informants reported estimated time from symptom onset to first medical visit diagnosis. Univariate analysis of general linear model was used examine potential delayed diagnosis seeking.The median duration noticeable or treatment 1.77 years....
To assess the influence of education on performance Chinese version Montreal cognitive assessment (C-MoCA) in relation to mini-mental state examination (MMSE) detecting amnesic mild impairment (aMCI) among rural-dwelling older people C-MoCA and MMSE was administered diagnostic interviews were conducted community-dwelling elderly two villages Beijing. The aMCI evaluated by area under ROC curve (AUC). Effect size variations scores estimated with general linear model. Among 172 study...
Abstract The four and a half LIM domains 2 (FHL2) has been shown to play important roles in the regulation of cell proliferation, survival, adhesion, motility signal transduction type tissue-dependent manner. However, function FHL2 ovarian physiology pathology is unclear. aim this study was determine role functional mechanism progression granulosa tumors (GCTs). Immunohistochemical analysis indicated that overexpressed GCT tissues. Cellular localization cells cycle dependent. Knockdown...
Abstract Background Little is known regarding the association of interviewer-reported cognitive problems (ICP) with age-related decline. We aimed to investigate independent associations ICP and combined self-reported (SCP) subsequent decline dementia in two prospective cohort studies. Methods included 10,976 Chinese (age = 57.7 ± 8.7) 40,499 European 64.6 9.4) adults without from China Health Retirement Longitudinal Study (CHARLS) Survey Health, Ageing, Europe (SHARE). Self-rated memory...
What is known and objective Research on genetic factors associated with antitubercular drug-induced liver injuries (ATLI) has been reported. However, most of the research focused polymorphisms genes encoding metabolic enzymes, including NAT2, GST CYP450. It probable that immune system also contributes to onset drug adverse effects. A few small studies have explored possible association HLA (DILI), but more supportive evidence from larger or prospective cohort designs needed. We aim explore...
ABSTRACT Study objectives: Based on a cohort from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), we aimed to evaluate relationship between sleep duration and incidence of cognitive impairment among older adults. Methods: We conducted prospective analysis based 3692 participants CLHLS at baseline (in 2011), as 3-year follow-up (till 2014), 531 (14.4%) had impairment, which was defined Mini-Mental State Examination score <24. Sleep classified into three groups: short (≤5...
Major depressive disorders (MDD) is a common mental disorder with high prevalence, frequent relapse and associated heavy disease burden. Heritability, environment their interaction play important roles in the development of MDD. MDD patients usually display wide variation clinical symptoms signs, while diagnosis relatively subjective. The treatment response varies substantially between different subtypes only half respond adequately to first antidepressant. This study aims define MDD,...