A5100601692- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Kruppel-like factors research
- Physiological and biochemical adaptations
- Plant and animal studies
- Animal Behavior and Reproduction
- Cancer-related gene regulation
- Insect and Pesticide Research
- MicroRNA in disease regulation
- Insect Utilization and Effects
- Insect symbiosis and bacterial influences
- GABA and Rice Research
- Genetics, Aging, and Longevity in Model Organisms
- Aquaculture Nutrition and Growth
- Genetic Syndromes and Imprinting
- bioluminescence and chemiluminescence research
- Electron Spin Resonance Studies
- Insect Resistance and Genetics
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
- Sulfur Compounds in Biology
- Viral Infectious Diseases and Gene Expression in Insects
- CRISPR and Genetic Engineering
- Plant Virus Research Studies
- Chromosomal and Genetic Variations
Institute of Zoology
2015-2025
Chinese Academy of Sciences
2016-2025
University of Chinese Academy of Sciences
2018-2025
Hubei University of Medicine
2020-2024
Hubei University
2024
Jiangsu Vocational College of Medicine
2024
Fujian Agriculture and Forestry University
2024
Soochow University
2013-2023
First Affiliated Hospital of Soochow University
2023
Second Affiliated Hospital of Soochow University
2014-2020
Locusts are one of the world's most destructive agricultural pests and represent a useful model system in entomology. Here we present draft 6.5 Gb genome sequence Locusta migratoria, which is largest animal sequenced so far. Our findings indicate that large size L. migratoria likely to be because transposable element proliferation combined with slow rates loss for these elements. Methylome transcriptome analyses reveal complex regulatory mechanisms involved microtubule dynamic-mediated...
Behavioral plasticity is the most striking trait in locust phase transition. However, genetic basis for behavioral locusts largely unknown. To unravel molecular mechanisms underlying change migratory Locusta migratoria, gene expression patterns over time courses of solitarization and gregarization were compared by oligonucleotide microarray analysis. Data analysis revealed that several categories relevant to peripheral olfactory perception are strongly regulated a total 1,444 differentially...
To identify the function of HAb18G/CD147 in invasion host cells by severe acute respiratory syndrome (SARS) coronavirus (CoV), we analyzed protein-protein interaction among HAb18G/CD147, cyclophilin A (CyPA), and SARS-CoV structural proteins coimmunoprecipitation surface plasmon resonance analysis. Although none was found to be directly bound nucleocapsid (N) protein CyPA, which interacted with HAb18G/CD147. Further research showed that a transmembrane molecule, highly expressed on 293 CyPA...
Abstract Tumor invasion and metastasis are the main causes of death from cancer. Epithelial to mesenchymal transition (EMT) is a determining step for cancer cell progress noninvasive invasive state. Krüppel-like factor 8 (KLF8) plays key role in oncogenic transformation highly overexpressed several types human cancer, including breast To understand KLF8 regulating progression we first established stable expression an immortalized normal epithelial line. We found that strongly induced EMT...
The migratory locust, Locusta migratoria , shows a striking phenotypic plasticity. It transitions between solitary and gregarious phases in response to population density changes. However, the molecular mechanism underlying phase-dependent behavior changes remains elusive. Here we report genome-wide gene expression profiling of nymphs at each stadium identified most differentially expressed genes fourth two phases. Bioinformatics analysis indicated that catecholamine metabolic pathway was...
Abstract Background Laodelphax striatellus Fallén (Hemiptera: Delphacidae) is one of the most destructive rice pests. L. different from 2 other planthoppers with a released genome sequence, Sogatella furcifera and Nilaparvata lugens, in many biological characteristics, such as host range, dispersal capacity, vectoring plant viruses. Deciphering will further understanding genetic basis differences among 3 planthoppers. Findings A total 190 Gb Illumina data 32.4 Pacbio were generated used to...
Abstract Motivation: Identifying piwi-interacting RNAs (piRNAs) of non-model organisms is a difficult and unsolved problem because piRNAs lack conservative secondary structure motifs sequence homology in different species. Results: In this article, k-mer scheme proposed to identify piRNA sequences, relying on the training sets from non-piRNA sequences five model species sequenced: rat, mouse, human, fruit fly nematode. Compared with existing ‘static’ based position-specific base usage, our...
Dysfunction of the circadian rhythm is one most common nonmotor symptoms in Parkinson's disease (PD), but molecular role PD unclear. We here showed that inactivation brain and muscle ARNT-like 1 (BMAL1) 1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine (MPTP)-treated mice resulted obvious motor functional deficit, loss dopaminergic neurons (DANs) substantia nigra pars compacta (SNpc), decrease dopamine (DA) transmitter, increased activation microglia astrocytes striatum. Time on rotarod or...
Phenotypic plasticity occurs prevalently and plays a vital role in adaptive evolution. However, the underlying molecular mechanisms responsible for expression of alternate phenotypes remain unknown. Here, density-dependent phase polyphenism Locusta migratoria was used as study model to identify key signaling molecules regulating phenotypic plasticity. Metabolomic analysis, using high-performance liquid chromatography gas chromatography–mass spectrometry, showed that solitarious gregarious...
Systemic RNAi, the spreading of RNAi effects to cells and tissues that have not initially encountered a dsRNA trigger, is common phenomenon in many organisms. However, underlying mechanisms systemic remain largely unknown. Here, we studied characteristics possible Locusta migratoria. We observed locust has pronounced sensitive response injection for both broadly-expressed as well tissue-specific genes. Only 30 pg (dsRNA / mg tissues) dose could induce significant effects. one SID-1 ortholog...
Locusts represent the excellent model of insect olfaction because animals are equipped with an unusual olfactory system and display remarkable density-dependent plasticity. However, information regarding receptor molecules involved in perception locusts is very limited. On basis genome sequence antennal transcriptome migratory locust, we conduct identification functional analysis two families: odorant receptors (ORs) ionotropic (IRs). In there expansion OR family (142 ORs) while distinctly...
Hydrogels have been widely used in water purification. However, there is not much discussion and comparison about the effects of different nanofillers on reinforcement adsorption performances hydrogels, which can be subjected to rapid flow possess strong ability. In this work, polyacrylamide (PAAM)-sodium alginate (SA) interpenetrating polymer network-structured hydrogels were prepared by situ polymerization. PAAM formed first flexible network SA constructed second rigid network. Three kinds...
Phenylacetonitrile acts as an aposematic signal and toxin precursor against predation in locusts.
Long-term flight depends heavily on intensive energy metabolism in animals; however, the neuroendocrine mechanisms underlying efficient substrate utilization remain elusive. Here, we report that adipokinetic hormone/corazonin-related peptide (ACP) can facilitate muscle lipid a famous long-term migratory flighting species,
KLF8 (Krüppel-like factor 8) is a member of the Krüppel transcription family that binds CACCC elements in DNA and activates or represses their target genes context-dependent manner. Here we present sumoylation as novel mechanism regulates post-translationally. We found can be covalently modified by small ubiqitin-like modifier (SUMO)-1, SUMO-2, SUMO-3 vivo. showed interacted with PIAS SUMO E3 ligases PIAS1, PIASy, PIASxalpha but not E2 SUMO-conjugating enzyme Ubc9. Furthermore, demonstrated...
Spirulina (Arthrospira) platensis is the most commonly produced microalgae for commercial applications, such as nutraceuticals and feed. While crop productivity of farms often compromised by grazers contaminating microzooplanktons, biodiversity identity harmful microzooplanktons in have not been extensively studied. As China number one producer world, comprehensive information on essential long-term viability these farms. Therefore, we determined major that are present eight cultivation...
Behavioral plasticity is widespread in swarming animals, but little known about its underlying neural and molecular mechanisms. Here, we report that a neuropeptide F (NPF)/nitric oxide (NO) pathway plays critical role the locomotor of migratory locusts. The transcripts encoding two related neuropeptides, NPF1a NPF2, show reduced levels during crowding, transcript NPF2 receptors significantly increase locust isolation. Both have suppressive effects on phase-related activity. A key downstream...
Animals often exhibit dramatically behavioral plasticity depending on their internal physiological state, yet little is known about the underlying molecular mechanisms. The migratory locust, Locusta migratoria, provides an excellent model for addressing these questions because of famous phase polyphenism involving remarkably between gregarious and solitarious phases. Here, we report that a major insect hormone, juvenile involved in regulation this related to change by influencing expression...