A5100326949- Sirtuins and Resveratrol in Medicine
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Platelet Disorders and Treatments
- Pharmacological Effects of Natural Compounds
- Antiplatelet Therapy and Cardiovascular Diseases
- RNA modifications and cancer
- Traditional Chinese Medicine Analysis
- Autophagy in Disease and Therapy
- Chemical Synthesis and Analysis
- Cardiac, Anesthesia and Surgical Outcomes
- Hip and Femur Fractures
- Osteoarthritis Treatment and Mechanisms
- Cardiac Arrest and Resuscitation
- Plant-based Medicinal Research
- RNA Research and Splicing
- Cell Adhesion Molecules Research
- Flavonoids in Medical Research
- Cardiac and Coronary Surgery Techniques
- Metabolomics and Mass Spectrometry Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Peripheral Artery Disease Management
- Isotope Analysis in Ecology
- Blood transfusion and management
Guiyang Medical University
2018-2025
Tianjin Medical University
2025
Second People’s Hospital of Yibin
2024
The Second Affiliated Hospital of Bengbu Medical College
2024
Xiamen University
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2005-2024
Jiangsu University
2019-2024
First People's Hospital of Kunshan
2019-2024
Peking University
2020-2024
Fu Wai Hospital
2024
Abstract Tumor invasion and metastasis are the main causes of death from cancer. Epithelial to mesenchymal transition (EMT) is a determining step for cancer cell progress noninvasive invasive state. Krüppel-like factor 8 (KLF8) plays key role in oncogenic transformation highly overexpressed several types human cancer, including breast To understand KLF8 regulating progression we first established stable expression an immortalized normal epithelial line. We found that strongly induced EMT...
CircMYO10 is a circular RNA generated by back-splicing of gene MYO10 and upregulated in osteosarcoma cell lines, but its functional role still unknown. This study aimed to clarify the mechanism circMYO10 osteosarcoma.CircMYO10 expression 10 paired chondroma tissues was assessed quantitative reverse transcription polymerase chain reaction (PCR). The function circMYO10/miR-370-3p/RUVBL1 axis regarding two key characteristics: proliferation endothelial-mesenchymal transition (EMT)....
Rationale: Osteoarthritis (OA) is the most common joint disease worldwide. Previous studies have identified imbalance between extracellular matrix (ECM) catabolism and anabolism in cartilage tissue as main cause. To date, there no cure for OA despite a few symptomatic treatments. This study aimed to investigate role of CircCDK14, novel circRNA factor, progression OA, elucidate its underlying molecular mechanisms. Methods: The function CircCDK14 well interaction downstream target...
A new compact superconducting synchrocyclotron single-room proton solution delivers pulsed beams to each spot through several irradiation bursts calculated by an iterative layer delivery algorithm. Such a mechanism results in beam parameter, burst switching time (BST) the total (BDT) which has never been studied before. In this study, we propose experimental approach build accurate BDT and sequence prediction model for solution.Test fields clinical treatment plans were used investigate...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTStereocontrolled Total Synthesis of (±)-GelsemineTohru Fukuyama and Gang LiuView Author Information Department Chemistry, Rice University Houston, Texas 77005-1892 Faculty Pharmaceutical Sciences Tokyo Hongo, Bunkyo-ku, 113, Japan Cite this: J. Am. Chem. Soc. 1996, 118, 31, 7426–7427Publication Date (Web):August 7, 1996Publication History Received20 May 1996Published online7 August inissue 1 January...
Long non-coding RNAs (lncRNAs) exert important functions involved in tumorigenesis and cancer progression including esophageal squamous cell (ESCC), however, the clinical role underlying biological function of Small Nucleolar RNA Host Gene 1 (SNHG1) ESCC is not well known.Quantitative Real-time polymerase chain reaction (QRT-PCR) was used to detect SNHG1 expression levels tissues adjacent non-cancerous tissues. Chi-square test evaluate association between clinicopathological features...
Platelets in the primary tumor microenvironment play crucial roles regulation of progression, but mechanisms underlying are poorly understood. Here, we report that platelet releasates exerted a proliferative effect on hepatocellular carcinoma (HCC) cells both vitro and vivo. This depended reduction KLF6 expression HCC cells. After incubation with either platelets or granule contents, SMMC.7721 HepG2 exhibited significant increases proliferation decreases apoptosis. However, no was observed...
The objective of this study is to quantify the clinical accuracy Cyberknife Xsight Lung Tracking System (XLTS) in our center and calculate PTV margin XLTS treated lung tumors. Data from treatment log files 22 cancer patients with CyberKnife were analyzed was calculated. Segmentation, deformation, correlation, prediction targeting errors calculated treatments. Two different methods used anisotropic margin. relationships between tumor motion ranges correlation also analyzed. Based on...
Abstract This study aimed to evaluate the causal effects of inflammatory bowel disease (IBD) and erectile dysfunction (ED) using Mendelian randomization (MR). All datasets were obtained from public genome-wide association database. In exposure group, 12,882 IBD patients 21,770 controls included. A total 1154 ED 94,024 included in outcome group. Two-sample MR was conducted estimate effect on ED. Furthermore, Crohn's (CD) ulcerative colitis (UC) factors subgroup analyses. Weighted median,...
Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown etiology, characterized by high fever, transient cutaneous rash, arthralgia/arthritis, and leukocytosis. Liver involvement in AOSD has been described, but few reports have described it depth. The present study analyzed clinical laboratory features series Chinese patients.Data 77 patients with (fulfilling Yamaguchi's diagnostic criteria) were retrospectively reviewed compared other series.The characteristics our...
Flavonoids exert both anti-oxidant and anti-platelet activities in vitro vivo. Pentamethylquercetin (PMQ), a polymethoxylated flavone derivative, has been screened for anti-carcinogenic cardioprotective effects. However, it is unclear whether PMQ anti-thrombotic In the present study, (20 mg/kg) significantly inhibited thrombus formation collagen- epinephrine- induced acute pulmonary thrombosis mouse model ferric chloride-induced carotid injury model. To explore mechanism, we evaluated...
Macro-porous fibrin scaffold was fabricated and used to induce cartilage regeneration<italic>in situ</italic>without pre-loaded cells or growth factors.
Abstract This study evaluated the effects of berberine on growth performance, immunity, haematological parameters, antioxidant capacity, and expression immune response‐related genes in lipopolysaccharide (LPS)‐challenged broilers. We assigned 120 one‐day‐old male broilers (Ross 308) to two treatment groups; each group included subgroups, which six replicates five birds per replicate. The experiment used a 2 × factorial arrangement with (0 or 60 mg/kg dietary) challenge status [injection...
Abstract We estimated the emissions of different forms gaseous nitrogen (N) from natural terrestrial ecosystems using newly upscaled soil δ15N maps, data-constrained gas partitioning models, and incorporating previously missing N input flux rock weathering. The for nitrous oxide (N2O), nitric (NO) dinitrogen (N2) are at 12±3, 19±4, 12±3 Tg yr-1, respectively. CMIP6 models tend to overestimate total thus N2O emissions. Correcting these match maps applying models’ emission estimates drop 7±2...
Patients with acute-on-chronic liver failure (ACLF) have a high mortality rate, poor prognosis, and often experience concurrent thrombocytopenia bleeding events. To evaluate the efficacy safety of recombinant human thrombopoietin (rhTPO) in patients ACLF concomitant severe thrombocytopenia. This was prospective, open-label study. We assigned 70 into rhTPO group control group, 35 each group. received subcutaneous injections at dose 15000 IU/day for 7 consecutive days, while did not receive...