Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown etiology, characterized by high fever, transient cutaneous rash, arthralgia/arthritis, and leukocytosis. Liver involvement in AOSD has been described, but few reports have described it depth. The present study analyzed clinical laboratory features series Chinese patients.Data 77 patients with (fulfilling Yamaguchi's diagnostic criteria) were retrospectively reviewed compared other series.The characteristics our...

Atherosclerosis (AS) is a chronic inflammatory disease characterized by lipid metabolism disorder and vascular endothelial damage. Albiflorin (AF) has been certified to be effective in the therapy of certain diseases, while therapeutic effect mechanism AF on AS have not fully elucidated. Material Methods. Model cells for were created inducing oxidized low-density lipoprotein (Ox-LDL) human umbilical vein (HUVECs). After processing with interleukin-1 receptor-associated kinase 1- (IRAK1-)...

Bortezomib is an effective drug for the treatment of multiple myelomas. However, its long-term effectiveness limited by development resistance. Oridonin, a natural diterpenoid purified from Rabdosia rubescens, has potential to diminish resistance bortezomib. To examine mechanism underlying diminution bortezomib-resistance in myeloma oridonin, we have created bortezomib-resistant cell line cells (RPMI-8226R). Using MTT assay, apoptosis assays and western blot analysis, evaluated compared...

To explore the clinicopathologic features, differential diagnosis and therapy of myeloid sarcoma.The clinical data including manifestations, laboratorial tests, histopathologicical examination, immunohistochemistry prognosis 10 patients with sarcoma were analyzed retrospectively. Among patients, 5 male female, aged 23 to 71 years old (median = 36 years).2 cases secondary from chronic leukemia, 1 occurred after allogeneic hematopoietic stem cell transplantation due acute others lacked...

To explore the values of tissue factor (TF) and vascular endothelial growth (VEGF) expressions on peripheral CD14+ monocytes in disease assessment, prognosis, short-term efficacy evaluation non-Hodgkin lymphoma (NHL) patients.TF VEGF CD14+monocytes 47 NHL patients (disease group) before chemotherapy after 4 cycles 30 healthy subjects (control were detected by flow cytometry, potential relationship among TF, VEGF, International Prognostic Index (IPI), analyzed.TF CD14 + group significantly...

To investigate the clinical significance of tissue factor (TF) and vascular endothelial growth (VEGF) expression on peripheral blood CD14 positive monocytes in patients with diffuse large B cell lymphoma (DLBCL).The expressions TF VEGF CD14+ 41 DLBCL (DLBCL group) before chemotherapy after 4 chemotherapeutic courses, 20 healthy subjects (control were detected by flow cytometry respectively, meanwhile, relationship international prognostic indexes (IPI) short-term effects analysed.The levels...

目的 探讨不典型慢性粒细胞白血病（aCML）患者的临床和实验室特点。 方法 应用骨髓穿刺术、骨髓活组织检查术、流式细胞术、染色体G显带技术、实时定量聚合酶链反应技术（RQ-PCR）、等位基因特异性聚合酶链反应技术（AS-PCR）等方法对1例aCML患者的骨髓形态学、骨髓组织学、免疫表型、染色体核型、融合基因、JAK2基因V617F点突变等进行检测。 结果 患者临床表现为低血糖昏迷，白细胞和血小板轻度增高，肝脏轻度大，脾脏中度大。骨髓粒系增生极度活跃，以中晚幼粒细胞及以下阶段细胞为主，粒系、红系及巨核系不同程度病态造血。染色体分析示der (22) t(1; 22）（q21; p13）核型。bcr-abl融合基因阴性，JAK2基因V617F点突变阴性。应用羟基脲治疗29个月后，患者双足皮肤出现顽固性溃疡，湿敷粒细胞-巨噬细胞集落刺激因子等对症治疗8周痊愈。 结论 aCML的临床表现缺乏特异性，正确诊断需结合骨髓形态学、细胞遗传学和分子生物学检查，预后差。

目的 观察含低剂量地塞米松改良VAD方案治疗初治多发性骨髓瘤(MM)的临床疗效和患者不良反应。 方法 将49例初治MM患者按治疗方案不同分成对照组23例和试验组26例，分别采用标准VAD方案和改良VAD方案进行化疗，治疗4个疗程后评价两组患者临床疗效和不良反应。 结果 试验组与对照组完全缓解率[11.54 %(3/26)比17.39 %(4/23)]、总有效率[73.08 %(19/26)比78.26 %(18/23)]、总体生存率(57.69％比52.17%)、中位生存时间(21.5个月比21.0个月)差异均无统计学意义(均P>0.05)。试验组Ⅲ、Ⅳ度骨髓抑制率[26.92 %(7/26)比65.22 %(15/23)]、感染率[23.08 %(6/26)比52.17 %(12/23)]与对照组比较降低(均P 0.05)。 结论 含低剂量地塞米松改良VAD方案治疗初治MM的临床疗效与标准VAD方案相似，但其骨髓抑制程度轻，感染率低，患者容易耐受。

目的 探讨IgE型多发性骨髓瘤（MM）的临床特征及治疗效果。 方法 收集蚌埠医学院附属连云港医院收治的1例以及文献报道的6例IgE型MM患者的临床资料，分析其临床表现、实验室特点及治疗效果。 结果 7例MM患者中，男性5例，女性2例，年龄40~59岁，平均年龄（52.4±6.0）岁；临床表现：贫血5例，肾损害3例，感染2例，高钙血症2例，骨骼疼痛5例，均呈溶骨性破坏，4例伴有病理性骨折；Durie-Salmon分期：ⅡA期4例，ⅢB期3例；血清免疫固定电泳分型：IgE-κ型3例，IgE-λ型4例；治疗效果：6例接受联合化疗和（或）自体外周血造血干细胞移植，完全缓解3例，部分缓解2例，疾病稳定1例，其中3例接受硼替佐米或造血干细胞移植治疗均获完全缓解。 结论 IgE型MM非常罕见，准确分型依赖血清免疫固定电泳，基于硼替佐米以及造血干细胞移植的治疗效果良好。

Objective To investigate the clinical and laboratory features of IgG-2κ light chain multiple myeloma. Methods The data results 2 myeloma (MM) patients with were analyzed related literatures reviewed. Results Two male 1 female 50-82 years old mainly suffered backache, infection, anemia renal dysfunction. Multiple osteolytic bone destruction was detected in X-ray as well magnetic resonance imaging (MRI). The level serum IgG normal, slight or obviously increased, but levels IgA IgM...

Objective To analyze some related causes of hypocytosis or hematocytosis with bone marrow dry pumping. Methods Bone histology, reticular fiber staining and selective immunohistochemical were performed in 34 pumping patients the Second People's Hospital Lianyungang from January 2012 to August 2017. Results All showed dizziness, fatigue, splenomegaly, night sweats bleeding, including primary myelofibrosis (17 cases, 50.0%), chronic myelocytic leukemia (4 11.8%), acute (2 5.9%),...

目的 探讨由骨髓增生异常综合征（MDS）转化的急性髓系白血病（AML）出现费城染色体（Ph）的特点。 方法 对1例血小板减少患者的骨髓形态学、组织学、免疫学、细胞遗传学、分子生物学等结果进行追踪观察，并复习相关文献。 结果 该患者血小板单系减少，无肝脾大，骨髓巨核细胞成熟障碍，血小板相关抗体阴性，正常染色体核型，对糖皮质激素治疗无反应；7个月后出现骨髓巨核细胞病态造血以及+8染色体；21个月后进展为AML，出现包含t（9；22）（q34；q11.2）的复杂染色体以及bcr-abl融合基因，采用伊马替尼联合HA、CAG方案化疗无反应。 结论 由MDS转化的AML出现Ph染色体非常罕见，与MDS疾病进展以及不良预后有关。

Objective To investigate the expressions of tissue factor (TF) and vascular endothelial growth (VEGF) in diffuse large B-cell lymphoma (DLBCL) their clinical significances. Methods The data 80 cases DLBCL diagnosed at Second People's Hospital Lianyungang from January 2010 to December 2017 were collected, 30 reactive hyperplasia lymph node (RLN) selected as controls. The TF VEGF two groups detected by using immunohistochemical staining. Results The positive rate group was higher...