A5048521154- Adipose Tissue and Metabolism
- Natural product bioactivities and synthesis
- Angiogenesis and VEGF in Cancer
- PARP inhibition in cancer therapy
- NF-κB Signaling Pathways
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer, Hypoxia, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Fibrosis and Remodeling
- Platelet Disorders and Treatments
- Phytochemical Studies and Bioactivities
- Adipokines, Inflammation, and Metabolic Diseases
- Traditional Chinese Medicine Analysis
- Signaling Pathways in Disease
- Nuclear Receptors and Signaling
- Autophagy in Disease and Therapy
- Kruppel-like factors research
- Aortic aneurysm repair treatments
- Hormonal Regulation and Hypertension
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Genetics and Neurodevelopmental Disorders
- Cancer-related gene regulation
Union Hospital
2018-2025
Huazhong University of Science and Technology
2016-2025
Union Hospital
2017-2025
Wuhan Union Hospital
2021
Southern Medical University
2018
Abstract Vascular calcification is highly prevalent in end-stage renal diseases and predictive of cardiovascular events mortality. Poly(ADP-ribose) polymerase 1 (PARP1) inhibition or deletion vasoprotective several disease models. Here we show that PARP activity increased radial artery samples from patients with chronic failure, arteries uraemic rats, calcified vascular smooth muscle cells (VSMCs) vitro. PARP1 deficiency blocks, whereas overexpression exacerbates, the transdifferentiation...
Abstract Macrophage inflammation plays a central role during the development and progression of sepsis, while regulation macrophages by parthanatos has been recently identified as novel strategy for anti‐inflammatory therapies. This study was designed to investigate therapeutic potential mechanism pimpinellin against LPS‐induced sepsis. PARP1 PAR activation were detected western blot or immunohistochemistry. Cell death assessed flow cytometry blot. metabolism measured with Seahorse XFe24...
Abstract Aims The heart undergoes pathological remodelling, featured by the hypertrophic growth of cardiomyocytes and increased cardiac fibrosis, under biomechanical stress such as haemodynamic overload. Ring Finger Protein 207 (RNF207) is an E3 ubiquitin ligase that predominantly expressed in heart, but its function remains elusive. In this study, we aimed to explore role RNF207 development hypertrophy dysfunction. Methods results Transverse aortic constriction (TAC) surgery was performed...
Abstract Background Angiogenesis is essential for tissue repair in ischemic diseases, relying on glycolysis as its primary energy source. Prolyl 4-hydroxylase subunit alpha 1 (P4HA1), the catalytic of collagen prolyl 4-hydroxylase, a glycolysis-related gene cancers. However, role glycolysis-induced angiogenesis remains unclear. Methods P4HA1 expression was modulated using adenoviruses. Endothelial evaluated through 5-ethynyl-2′-deoxyuridine incorporation, transwell migration, and tube...
Platelets in the primary tumor microenvironment play crucial roles regulation of progression, but mechanisms underlying are poorly understood. Here, we report that platelet releasates exerted a proliferative effect on hepatocellular carcinoma (HCC) cells both vitro and vivo. This depended reduction KLF6 expression HCC cells. After incubation with either platelets or granule contents, SMMC.7721 HepG2 exhibited significant increases proliferation decreases apoptosis. However, no was observed...
Abstract Purpose Angiogenesis is involved in many pathological and physiological processes mainly driven by hypoxia. Karyopherin subunit alpha 2 (KPNA2), a member of the nuclear transport protein family, was recently shown to be induced hypoxia various types tumours, so we aimed investigate role mechanism KPNA2 angiogenesis under Materials methods After overexpression or knockdown human umbilical vein endothelial cells (HUVEC) adenovirus vector infection, tube formation, proliferation...
C1q/tumor necrosis factor-related protein 13 (CTRP13) is a secreted adipokine that can ameliorate abnormal glucose and lipid metabolism. However, the functional role of CTRP13 in development atherosclerotic plaques has yet to be described. In this study, we collected blood samples from patients coronary artery diseases apolipoprotein E (ApoE)-/- mice were fed Western diet for 12 wk induce atherosclerosis found serum level was decreased. En face staining aortas aortic sinus ApoE-/- showed...
Flavonoids exert both anti-oxidant and anti-platelet activities in vitro vivo. Pentamethylquercetin (PMQ), a polymethoxylated flavone derivative, has been screened for anti-carcinogenic cardioprotective effects. However, it is unclear whether PMQ anti-thrombotic In the present study, (20 mg/kg) significantly inhibited thrombus formation collagen- epinephrine- induced acute pulmonary thrombosis mouse model ferric chloride-induced carotid injury model. To explore mechanism, we evaluated...
Deciphering the molecular and cellular processes involved in foam cell formation is critical to understanding pathogenesis of atherosclerosis. Interferon regulatory factor 1 (IRF1) was first identified as a transcriptional regulator type-I interferons (IFNs) IFN inducible genes. Our study aims explore role IRF1 atherosclerotic understand functional diversity various types contributing Methods: We induced experimental atherosclerosis ApoE-/-IRF1-/- mice evaluated effect on disease progression...
Obesity is a growing global health threat, and inducing browning of white adipose tissue (WAT) to increase energy expenditure has become an attractive strategy for treating obesity related metabolic complications. BRCA1-associated protein 1 (BAP1), ubiquitin C-terminal hydrolase (UCH) domain-containing deubiquitinase (DUB) expressed broadly across tissues, previously been shown play important role in liver carbohydrate lipid metabolism. However, its the inguinal (iWAT) not studied. Our study...
<p dir="ltr">Obesity is a growing global health threat, and inducing browning of white adipose tissue (WAT) to increase energy expenditure has become an attractive strategy for treating obesity related metabolic complications. <a href="" target="_blank">BRCA1-associated protein 1</a> (BAP1), ubiquitin C-terminal hydrolase (UCH) domain-containing deubiquitinase (DUB) expressed broadly across tissues, previously been shown play important role in liver carbohydrate lipid...
<p dir="ltr">Obesity is a growing global health threat, and inducing browning of white adipose tissue (WAT) to increase energy expenditure has become an attractive strategy for treating obesity related metabolic complications. <a href="" target="_blank">BRCA1-associated protein 1</a> (BAP1), ubiquitin C-terminal hydrolase (UCH) domain-containing deubiquitinase (DUB) expressed broadly across tissues, previously been shown play important role in liver carbohydrate lipid...
ABSTRACT Pathological cardiac hypertrophy leads to heart failure. In this study, we aimed explore the role of transmembrane protein Tspan9 in development and We found that was upregulated hearts patients with hypertrophic cardiomyopathy (HCM), mice subjected transverse aortic constriction (TAC), as well phenylephrine‐induced neonatal rat cardiomyocytes (NRCMs). AAV9‐mediated overexpression (OE) mouse augmented TAC‐induced failure, while knockdown (KD) alleviated effect. Tspan9‐OE promotes...
Gut inflammation caused by diets could damage the intestinal barrier, which increases liver exposition to pathogenic substances. Toll-IL-1 receptor (TIR) domain-containing adaptor molecule-1 (Ticam1) is a key molecule in Toll-like receptors (TLRs) pathway, important for immune defense against pathogens such as bacteria or viruses. In this study, mouse epithelial cell (IEC) Ticam1 was knocked out suppress response metabolic dysfunction-associated steatohepatitis (MASH) investigate its...
ABSTRACT Numerous studies have documented erucin's anticancer and vasodilatory properties, yet its impact on pathological cardiac hypertrophy remains to be fully understood. This study aimed explore the therapeutic potential of erucin in induced by pressure overload. Cardiac was mice transverse aortic constriction (TAC) surgery, neonatal rat cardiomyocytes via phenylephrine (PE) treatment. function remodeling were evaluated using echocardiography, histological assessment, molecular analyses....
Abstract Alogliptin is a commonly prescribed drug treating patients with type 2 diabetes. Here, we show that long‐term intervention alogliptin (0.03% w/w in diet) improves survival and health of mice on high‐fat diet. takes beneficial effects associated longevity, including increased insulin sensitivity, attenuated functionality decline, decreased organ pathology, preserved mitochondrial function, reduced oxidative stress. Autophagy activation proposed as an underlying mechanism these...
Endothelial dysfunction plays a crucial role in the progress of diabetic vasculopathy. C1q/tumor necrosis factor-related protein 13 (CTRP13) is secreted adipokine that can ameliorate atherosclerosis and vascular calcification. However, CTRP13 regulating endothelial function diabetes has yet to be explored. In this study, treatment improved endothelium-dependent relaxation aortae mesenteric arteries both db/db mice streptozotocin-injected mice. supplement also rescued impaired ex vivo mouse...
Myocardial ischemia-reperfusion (IR) injury occurs when occlusive coronary artery restores blood supply after events such as myocardial infarction, stroke, cardiac arrest and resuscitation, organ transplantation.However, the mechanisms involved are poorly understood, effective pharmacological interventions still lacking.A previous study demonstrated that 25-hydroxycholesterol (25-HC) contributed to lipid metabolism cholesterol an oxysterol molecule.We herein explored whether has...