This study was carried out to investigate the protective effects of leonurine hydrochloride (LH, from Leonurus sibiricus) on lipopolysaccharide (LPS)-stimulated broiler chicks. A total 120 one-day-old male Ross broilers were randomly divided into 4 treatment groups with 6 replicates 5 birds per cage. The experiment designed as a 2 × factorial arrangement LH (0 or mg/kg) and LPS (injection saline 1.5 mg/kg body weight) levels treatments. On days 14, 16, 18, 20 trial, intraperitoneally...

This study was performed to evaluate the beneficial effects of dietary leonurine hydrochloride (LH) supplementation on intestinal morphology and barrier integrity further illuminate its underlying antioxidant immunomodulatory mechanisms in lipopolysaccharide (LPS)-treated broilers. A total 120 1-d-old male broilers (Ross 308) were assigned 4 treatment groups with 6 replicates 5 birds per cage. The experiment designed a 2 × factorial arrangement LH (0 or mg/kg) LPS (injection saline 1.5 mg/kg...

Abstract This study evaluated the effects of berberine on growth performance, immunity, haematological parameters, antioxidant capacity, and expression immune response‐related genes in lipopolysaccharide (LPS)‐challenged broilers. We assigned 120 one‐day‐old male broilers (Ross 308) to two treatment groups; each group included subgroups, which six replicates five birds per replicate. The experiment used a 2 × factorial arrangement with (0 or 60 mg/kg dietary) challenge status [injection...

Endometritis is a common disease in postpartum cows, characterized by delayed uterine recovery due to endometrial inflammation. Although antibiotics and hormones are commonly used, they have certain limitations. One potential alternative using motherwort extract, specifically leonurine, which exhibits anti-inflammatory properties. However, leonurine's exact molecular mechanism of action remains unclear. In this study, 40 mice were randomly divided into four groups: control group,...

To discuss the effect of Glycyrrhiza uralensis (G. uralensis) Fisch polysaccharide on growth performance and immunologic function in mice Ural City, Xinjiang to provide important data supporting application polysaccharide. A total 100 Kunming aged 3 weeks old were randomly divided into 5 groups with 20 each group (10 females 10 males). About 0.5 mL normal saline was given control every day G. other at concentration 1, 20, 50 mg/mL, respectively. The (average body weight, average daily feed...

Background: The diameter of mature follicles in donkeys is several times larger than cattle and sheep, but the key genes responsible for maintaining follicular development preventing apoptosis remain unclear. Methods: This study observed process donkey using ultrasound analyzed changes common reproductive hormones serum. Granulosa cells (GCs) were collected from large (mature follicles, ≥ 37 mm) small (atretic 10–25 sequencing to screen differentially expressed (DEGs) signaling pathways...

Abstract Our previous studies showed that excessive fluoride (F) ingestion seriously damaged the nonspecific immune function in rabbits. However, underlying mechanisms of F‐induced damage to system are unclear. The purpose this study was investigate whether F induces thymus apoptosis female rats and its by monitoring ultrastructural changes DNA fragmentation. results induced significantly increased tail length tailing ratio lymphocytes. Protein (Pr) supplementation markedly decreased...

Abstract Background Previously, twelve Rickettsia species were identified in ticks, fleas, sheep keds ( Melophagus ovinus ), bats Pipistrellus pipistrellus ) and a tick-bitten patient the Xinjiang Uygur Autonomous Region (XUAR) northwestern China. Here we aimed to molecularly detect rickettsial agents red fox Vulpes vulpes marbled polecat Vormela peregusna their ticks. Methods During 2018–2019, 12 foxes, one ticks sampled two counties city of XUAR. The heart, liver, spleen, lung kidney these...

BACKGROUND This study performed optimized extraction, preliminary characterization, and in vitro antioxidant activities of polysaccharides from Glycyrrhiza uralensis Fisch. MATERIAL AND METHODS Three parameters (extraction temperature, ratio water to raw material, extraction time) were for yields G. (GUP) using response surface methodology with Box-Behnken design (BBD). The GUP was purified DEAE cellulose 32-column chromatography. main fraction obtained Fisch GUP-II, which composed rhamnose,...

Abstract Endometritis is a common disease in postpartum cows characterized by delayed uterine recovery due to inflammation of the endometrium. Although antibiotics and hormones are commonly used for treatment, they have their limitations. One potential alternative use motherwort extract, specifically leonurine, which has been found possess anti-inflammatory properties. However, exact molecular mechanism action remains unclear. To address this gap knowledge, study aimed investigate effects...

Abstract Rational water and fertiliser management have an important impact on alfalfa production. This research aimed to explore the effects of phosphorus (P) water‐use efficiency (WUE) phosphorus‐recovery (PRE) each cut under drip irrigation determine optimal interaction ratio improve quality yield alfalfa. Different levels were set, i.e., 5250, 6000 6750 m 3 /ha (referred as W 1 , 2 respectively), P (0, 50, 100 150 kg/ha O 5 referred 0 respectively) set hay nutrient irrigation. The...

Thirty-two Wistar rats were divided randomly into four groups of eight with six females and two males in each group. The exposed to high fluoride drinking water (45 mg F− L−1 from 100 NaF L−1), low dietary iodine (0.0855 kg−1), or both together order assess the effects these three regimens on thyroid function offspring rats. After animal model was established, bred 10-, 20-, 30-, 60-, 90-d-old used for experiment. treatments same as those their parents. In comparison control rats, relative...

Brucellosis is primarily a disease of domestic animals in which the bacteria localizes to fetal tissues such as embryonic trophoblast cells and fluids containing erythritol, stimulates Brucella spp. growth. The utilization erythritol characteristic genus Brucella. ery operon contains four genes (eryA, eryB, eryC eryD) for plays major role survival multiplication objective present study was conduct preliminary characterization differential expression at several time points after infected...

Abstract Alfalfa ( Medicago sativa L.)is an important forage with high quality and fine root turnover rate (FRTR). Soil phosphorus (P) availability greatly influences dry matter yield (DMY) persistence of alfalfa. However, the effects water (Wa)–P coupling under drip irrigation conditions on alfalfa FRTR DMY have been rarely studied. Therefore, a 2‐yr field experiment was established three randomized complete blocks in Xinjiang, China, evaluating amounts (5,250, 6,000, 6,750 m 3 ha −1 ,...

Polycystic ovary syndrome (PCOS) is an endocrine disease commonly associated with metabolic disorders in females. Leonurine hydrochloride (Leo) plays important role regulating immunity, tumours, uterine smooth muscle, and ovarian function. However, the effect of Leo on PCOS has not been reported. Here, we used dehydroepiandrosterone to establish a mouse model PCOS, some mice were then treated by gavage. We found that could improve irregular oestros cycle mice, reverse significantly greater...

The expression of flagellar proteins in Brucella species likely evolved through genetic transference from other microorganisms, and contributed to virulence, adaptability, biofilm formation. Despite significant progress defining the molecular mechanisms behind gene expression, program controlling formation remains unclear. transcriptional factor (FtcR) is a master regulator system's critical for B. melitensis 16M's biogenesis virulence. Here, we demonstrate that FtcR mediates under...

This study aimed to investigate the therapeutic effects of Glycyrrhiza uralensis polysaccharide (GUP) on glycinin-induced allergic reactions in mouse model. Female BALB/c mice were pretreated for seven consecutive days with various concentrations GUP aqueous solution or blank control. The then orally administered glycinin (10 mg/ml) three times and observed a week later. survival rate other indicators measured, while IL-4, IL-13, plasma histamine lgE IgG content serum detected by...

The infertility of milk cow is a world problem with high incidence rate. Reportedly, in the dairy industry, theproportion infertile was about 15% total mature cows (Donald L B, 1978, P.309), and someothers thought this number achieved 30% according to statistics (Bulman D C, 1980, P.177-188). In US, thereare 12%~19% which are eliminated through selection because sterility breeding diseases every year, andthis achieves above 40% all unqualified (Jiang, 1990, P.38-41). China, rate maturecows...

The Eurasian lynx (Lynx) is a medium-sized wild cat species distributed throughout Eurasia. There has been no report on Taenia (Cestoda: Cyclophyllidea) infecting this felid in China. In study, 24 tapeworms were found two lynxes (#1 and #2) Xinjiang Uygur Autonomous Region (XUAR), northwestern Based the number, measurements shape of rostellar hooks, these belong to species. According number (n = 32) length (185-194 μm) small first 1, #2 lynx) was identified as laticollis. Phylogenetically,...

The aim of the present study was to explore effects different dietary levels (0, 15, 30, 60, 120 mg/kg) leonurine hydrochloride (LHy) supplementation on growth performance, immune response, antioxidant capacity, hematological parameters and serum lipid profiles in broiler chicks. A total 600 1-day-old Ross × male broilers were randomly allocated five treatment groups consisting eight pens fifteen birds. feeding programme included a starter diet until day 21 finisher from 22 42. results...