A5101670690- Spine and Intervertebral Disc Pathology
- Spinal Hematomas and Complications
- Spinal Cord Injury Research
- Spondyloarthritis Studies and Treatments
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Cardiovascular Disease and Adiposity
- Tendon Structure and Treatment
- Mesenchymal stem cell research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoparticle-Based Drug Delivery
- Stroke Rehabilitation and Recovery
- Osteoarthritis Treatment and Mechanisms
- Veterinary Equine Medical Research
- Diabetic Foot Ulcer Assessment and Management
- Graphene research and applications
- MicroRNA in disease regulation
- Blood Coagulation and Thrombosis Mechanisms
- Esophageal Cancer Research and Treatment
- Toxin Mechanisms and Immunotoxins
- Neurological Complications and Syndromes
- Histone Deacetylase Inhibitors Research
- Graphene and Nanomaterials Applications
- Acute Ischemic Stroke Management
- Inflammasome and immune disorders
First Affiliated Hospital of Bengbu Medical College
2010-2025
Affiliated Hospital of Taishan Medical University
2025
Shandong First Medical University
2025
Hebei Yiling Hospital
2024
Union Hospital
2015-2023
Huazhong University of Science and Technology
2016-2023
Army Medical University
2021
Jilin University
2015
Shanghai Tenth People's Hospital
2014
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2014
Intervertebral disc (IVD) degeneration contributes largely to pathoanatomical and degenerative changes of spinal structure that increase the risk low back pain. Apoptosis in nucleus pulposus (NP) can aggravate IVD degeneration, increasing studies have shown interventions targeting NP cell apoptosis ameliorate exhibiting their potential for use as therapeutic strategies. Recent data advanced glycation end products (AGEs) accumulate tissues parallel with progression form a microenvironment...
The pathogenic process of intervertebral disc degeneration (IDD) is characterized by imbalance in the extracellular matrix (ECM) metabolism. Nucleus pulposus (NP) cells have important roles maintaining proper structure and tissue homeostasis ECM. These need adequate supply glucose oxygen. Islet amyloid polypeptide (IAPP) exerts its biological effects regulating purpose this study was to investigate expression IAPP degenerated IVD tissue, modulation ECM metabolism human NP cells, especially...
Lysophagy is a form of selective autophagy to remove unwanted lysosomes. However, its role in the pathogenesis intervertebral disc degeneration (IDD) remains unclear. We intended investigate relationship between lysophagy and ferroptosis, as well potential involved molecules during IDD. Human nucleus pulposus (NP) cells were obtained from clinical patients. The protein levels, colocalization cellular reactive oxygen species levels assessed by western blotting, immunofluorescence analysis,...
Low toxicity and high efficacy are the key factors influencing real-world clinical applications of nanomaterial-assisted drug delivery. In this study, novel hollow carbon spheres (HCSs) with narrow size distribution were developed. addition to demonstrating their ease synthesis for large-scale production, we also demonstrated in vitro that HCSs possessed drug-loading capacity, lower cell toxicity, optimal release profile at low pH, similar pH tumor microenvironment. The displayed excellent...
Osteoarthritis (OA) is an age-related progressive degenerative disorder characterized by cartilage extracellular matrix degradation and inflammation. In this study, we explored the function mechanism of action obacunone (OB) in inhibiting OA progression. The articular its severity were examined using Safranin O-fast green hematoxylin eosin (HE) staining. Chondrocyte survival was evaluated a cell counting kit-8 assay. addition, qRT-PCR, western blot analysis, immunohistochemical staining,...
Abstract Protease nexin-1 (PN-1) is a serine protease inhibitor belonging to the serpin superfamily. This study was undertaken investigate regulatory role of PN-1 in pathogenesis intervertebral disk (IVD) degeneration. Expression detected human IVD tissue varying grades. both mRNA and protein significantly decreased degenerated expression levels were correlated with grade disc Moreover, decrease primary NP cells confirmed. On induction by IL-1β, at day 7, 14 21, as shown western blot...
Background: Mesenchymal stem cells (MSCs) have shown great potential in the treatment of cardiovascular diseases, with fat being a more accessible source MSCs. This study investigated effect human adipose-derived mesenchymal (hMSCs-Ad) exosomes on T lymphocytes and its role atherosclerosis (AS).
Juvenile idiopathic arthritis (JIA) is the most common in adolescents under age of 16. Etanercept, an inhibitor tumor necrosis factor, often used to treat JIA despite its significant side effects. Homeopathic remedies, such as blueberries, have anti-inflammatory properties with fewer unwanted effects and should be considered a primary treatment. We aimed explore efficacy safety combination therapy blueberry etanercept for JIA. Two hundred one patients were selected, randomly evenly assigned...
Folic acid supplementation may meliorate cardiovascular disease risk by improving vascular endothelial structure and function. However, the underlying mechanisms are still lack of a global understanding. To be used, folic must converted to 7,8-dihydrofolate dihydrofolate reductase generate one-carbon derivatives serving as important cellular cofactors in synthesis nucleotides amino acids required for cell growth. Therefore, this study explored effect knockdown on EA.hy926 growth mechanism...
Objective: To investigate the roles of hypoxic stimulation in pathogenesis chronic rhinosinusitis with nasal polyps (CRSwNP) by comparing variation and differences inflammatory factors secreted from epithelial cells normal mucosa under stimulation. Methods: Sixty-eight patients who were diagnosed CRSwNP June 2015 to January 2018 at China-Japan Union Hospital Jilin University analyzed, including 36 males 32 females, aged (45.2±12.5) years. Nasal was included CRS-NP group inferior turbinate...
Goal: The purpose of this study was to evaluate the effectiveness vitamin C solution (VCS) in reducing adverse reactions caused by painless Lugol chromoendoscopy. Background: chromoendoscopy is an effective method for screening superficial esophageal squamous cell carcinoma, although iodine (LIS) causes mucosal irritation. Study: In 4 hospitals China, patients were randomized and divided into a distilled water (DW) group, sodium thiosulfate (STS) group VCS group. Patients’ surfaces stained...
Nucleus pulposus (NP) cell function-loss is one main contributor during intervertebral disc degeneration (IDD) progression. Both mitochondria and endoplasmic reticulum (ER) play vital roles in sustaining NP homeostasis, while the precise function of ER-mitochondria tethering cross talk IDD remain to be clarified. Here, we demonstrated that a notable disruption mitochondria-associated ER membrane (MAM) was identified degenerated discs TBHP-induced cells, accompanied by mitochondrial Zn
Objective To summarize the experience of clinical interventional therapy for post-thrombosis syndrome (PTS) and to explore optimal timing application principle. Method From January 2010 December 2017, 102 cases lower extremity PTS who underwent were retrospectively reviewed. Of these, 49 had percutaneous transluminal angioplasty (PTA) alone (PTA group, mainly before 2014) 53 PTA plus implantation stent (PTA+STENT which 20 implanted with trans-hip joint stent). Therapeutic effect was...
Objective To investigate the effect and safety of staged incremental balloon dilatation in interventional treatment Budd-Chiari syndrome (BCS) with inferior vena cava thrombosis. Methods From January 2016 to December 2018, clinical data 34 BCS patients thrombosis (18 males 16 females aged 32-53 years) admitted vascular surgery First Affiliated Hospital Bengbu Medical College were analyzed retrospectively. All treated by dilatation, namely whether thrombus was fresh or not, small (8...