A5084998685- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Hematopoietic Stem Cell Transplantation
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- Mesenchymal stem cell research
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- RNA modifications and cancer
- Immune cells in cancer
- Rabies epidemiology and control
- Microbial infections and disease research
- Gut microbiota and health
- Erythrocyte Function and Pathophysiology
- Genetic Associations and Epidemiology
- Folate and B Vitamins Research
- Neutropenia and Cancer Infections
- S100 Proteins and Annexins
- Hemoglobinopathies and Related Disorders
- Caveolin-1 and cellular processes
- Stroke Rehabilitation and Recovery
- Radiomics and Machine Learning in Medical Imaging
- Cytokine Signaling Pathways and Interactions
Henan Forestry Vocational College
2013-2025
First Affiliated Hospital of GuangXi Medical University
2025
Guangxi Medical University
2025
Huazhong University of Science and Technology
2024
The University of Texas Health Science Center at San Antonio
2024
The University of Texas Health Science Center at Houston
2024
Tianjin University of Science and Technology
2024
Cincinnati Children's Hospital Medical Center
2018-2022
Nanjing Medical University
2010-2021
Nanjing Maternity and Child Health Care Hospital
2021
Development of resistance to therapy continues be a serious clinical problem in lung cancer management. We previously identified that Annexin A2 is significantly up-regulated cisplatin-resistant non-small cell (NSCLC) A549/DDP cells. However, the exact function and molecular mechanism cisplatin NSCLCs has not been determined. Western blot qRT-PCR were performed analyze protein mRNA level indicated molecules, respectively. Immunohistochemistry was expression NSCLC tissue samples. MTS assay,...
Abstract Cervical cancer (CC) is one of the most deadly cancers in women, its current treatments still result poor outcomes and developing novel targets therapeutic strategies are urgently needed. Recent studies have shown that anti-silencing function 1B (ASF1B) might be used as a new proliferation marker for diagnosis prognosis. However, expression ASF1B cervical remain unclear. Here, we induced knockdown overexpression cell lines detected biological behavior changes vitro. Furthermore,...
Abstract ASH1L histone methyltransferase plays a crucial role in the pathogenesis of different diseases, including acute leukemia. While represents an attractive drug target, developing inhibitors is challenging, as catalytic SET domain adapts inactive conformation with autoinhibitory loop blocking access to active site. Here, by applying fragment-based screening followed medicinal chemistry and structure-based design, we developed first-in-class small molecule domain. The crystal structures...
SET domain containing 2 (Setd2), encoding a histone methyltransferase, is associated with many hematopoietic diseases when mutated. By generating novel exon 6 conditional knockout mouse model, we describe an essential role of Setd2 in maintaining the adult stem cells. Loss results leukopenia, anemia, and increased platelets accompanied by hypocellularity, erythroid dysplasia, mild fibrosis bone marrow. mice show significantly decreased progenitor cells except for progenitors. fail to...
This study aimed to assess the relationship between lifestyle risk factors and stroke, as well quantify causality, using data from National Health Nutrition Examination Survey (NHANES) Mendelian randomization (MR). We analyzed 28,226 individuals who participated in NHANES 1999 2020. To evaluate association we used weighted multivariate logistic regression. Genome-wide (GWAS) summary were utilized conduct bidirectional two-sample MR analyses. The observational found that waist circumference,...
Chromosomal instability is a prominent biological feature of Myelodysplastic Syndromes (MDS), with over 50% MDS patients harboring chromosomal abnormalities or complex karyotype. Despite this observation, the mechanisms underlying mitotic and defects in remain elusive. In study, we identified ectopic expression transcription factor ONECUT3, associated karyotypes poorer survival outcomes MDS. ONECUT3-overexpressing cell models exhibited enrichment several notable pathways, including...
Abstract Natural killer (NK) cells and T are key effectors of antitumor immune responses major targets checkpoint inhibitors. In multiple cancer types, we find that the expression Wnt signaling potentiator R-spondin genes (e.g., RSPO3) is associated with favorable prognosis positively correlates gene signatures both NK cells. Although endothelial cancer-associated fibroblasts comprise 3–producing cells, correspondingly express 3 receptor LGR6 within tumor microenvironment (TME). Exogenous or...
Although increased TNF-α has been considered to cause ineffective hematopoiesis in myelodysplastic syndromes (MDS), the mechanisms of elevation are not known. We recently found that c-Fos mRNA stabilization under translation-inhibiting stimuli was impaired MDS-derived neutrophilic granulocytes. In current study, we identified overexpression c-Fos-targeting miR-34a and miR-155 as impairment. Expression levels but inversely correlated with ratios c-Fos-positive cells CD16+ neutrophils (r =...
Although quantitative and qualitative granulocyte defects have been described in myelodysplastic syndromes (MDS), the underlying molecular basis of dysfunction MDS is largely unknown. We recently found that FOS mRNA elevation under translation-inhibiting stimuli was significantly smaller granulocytes from patients than healthy individuals. The aim this study to clarify cause impaired induction MDS. first examined mechanisms using donors cultured with translation inhibitor emetine. Emetine...
Traditional Chinese Medicine (TCM) is a practical medicine based on thousands of years medical practice in China. Arsenic dispensing powder (ADP) has been used as treatment for MDS patients with superior efficacy anemia at Xiyuan Hospital China Academy Medical Sciences. In this study, we retrospectively analyzed that received ADP the past 9 and confirmed improves patients’ prolongs overall survival intermediate-risk patients. Then, transgenic mice model cell line to explore drug mechanism....
The aim of this study was to investigate the biological role and molecular mechanism p22 phox in epithelial ovarian cancer.Immunohistochemistry employed determine expression level cancer tissues.The effects on cell proliferation, tumorigenesis, chemosensitivity were evaluated by CCK-8, EdU assay, colony formation apoptosis assays vitro mouse experiments vivo.Immunoprecipitation analyses utilized explore potential mechanisms mediated downstream signaling, RT-PCR western blot used confirm...