A5101466592- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Uterine Myomas and Treatments
- Neurofibromatosis and Schwannoma Cases
- Immune Cell Function and Interaction
- Neuroblastoma Research and Treatments
- Endometriosis Research and Treatment
- Pluripotent Stem Cells Research
- TGF-β signaling in diseases
- CRISPR and Genetic Engineering
- Gynecological conditions and treatments
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Kruppel-like factors research
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
- 3D Printing in Biomedical Research
- Intestinal and Peritoneal Adhesions
- Acute Lymphoblastic Leukemia research
- Cancer Research and Treatments
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Pelvic and Acetabular Injuries
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Cincinnati Children's Hospital Medical Center
2020-2024
Chongqing Medical University
2017-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
University of Southern California
2016-2024
Broad Center
2016-2024
Ruijin Hospital
2016
Huazhong University of Science and Technology
2011-2015
Tongji Hospital
2015
Xijing Hospital
2014
Air Force Medical University
2014
Objective To evaluate the clinical outcomes of high‐intensity focused ultrasound ( HIFU ) and surgery in treating uterine fibroids, prepare for a definitive randomised trial. Design Prospective multicentre patient choice cohort study IDEAL Exploratory study) , myomectomy or hysterectomy symptomatic fibroids. Setting 20 Chinese hospitals. Population sample 2411 women with Methods non‐randomised learning curve analysis Stage 2b Exploration Study). Main outcome measures Complications, hospital...
Objective Long-term re-intervention after ultrasound-guided high intensity focused ultrasound (USgHIFU) ablation was reported, and the prediction of non-perfusion volume ratio (NPVR) in differently aged patients with uterine fibroids (UFs) explored.
Abstract Twist, a master regulator of embryonic morphogenesis, induces functions that are also required for tumor invasion and metastasis. Because thrombin contributes to the malignant phenotype by up-regulating metastasis, we examined its effect on Twist in five different cell lines two endothelial lines. Thrombin up-regulated mRNA protein all seven Down-regulation B16F10 led ∼3-fold decrease growth chorioallantoic membrane assay ∼2-fold syngeneic mice. Angiogenesis was decreased ∼45% 36%,...
Objective: To investigate the factors which may cause thermal injury of abdominal wall structures in ultrasound-guided high-intensity focussed ultrasound (USgHIFU) ablation uterine fibroids.Method: A total 892 patients with fibroids diagnosed on contrast-enhanced magnetic resonance imaging (MRI) scans received HIFU and follow-up MRI scanning. After therapy, to skin was assessed via measurement redness, blisters, subcutaneous nodules signal intensity T2-weighted images. 151 were assigned...
Abstract Natural killer (NK) cells and T are key effectors of antitumor immune responses major targets checkpoint inhibitors. In multiple cancer types, we find that the expression Wnt signaling potentiator R-spondin genes (e.g., RSPO3) is associated with favorable prognosis positively correlates gene signatures both NK cells. Although endothelial cancer-associated fibroblasts comprise 3–producing cells, correspondingly express 3 receptor LGR6 within tumor microenvironment (TME). Exogenous or...
Plexiform neurofibromas (PNFs) are benign nerve tumors driven by loss of the NF1 tumor suppressor in Schwann cells. PNFs rich immune cells, but whether cells necessary for tumorigenesis is unknown. We show that inhibition stimulator interferon gene (STING) reduces plasma CXCL10, T cell and dendritic (DC) recruitment, formation. Further, mice lacking XCR-1 + DCs showed reduced tumor-infiltrating PNF tumors. Antigen-presenting from tumor-bearing promoted CD8 proliferation vitro, expressed high...
How mesenchymal stem cells (MSCs) promote tumor growth remains incompletely understood. Here, we show that stem-like (MSLCs) are commonly present in malignant pleural effusion or ascites of cancer patients, where they directly interact with cells. Chemokines and chemokine receptors, especially the CCL2/CCR2 pathway, involved this interaction. As a result, MSLCs exert tumor-promoting effects by enhancing proliferation colony formation tumor-repopulating The underlying molecular basis involves...
Introduction: Mouse embryonic stem cell (ESC) self-renewal can be maintained through dual inhibition of GSK3 and MEK kinases. has two highly homologous downstream kinases, extracellular signal-regulated kinase 1 2 (ERK1/2). However, the exact roles ERK1/2 in mouse ESC differentiation remain unclear. Methods: We selectively deleted or inhibited ERK1, ERK2, both using genetic chemical approaches combined with small molecule inhibitors. The effects ERK paralog-specific on were then assessed....
Abstract Neurofibromatosis Type I (NF1) is a common genetic disorder caused by mutations in the NF1 gene, which encodes RAS-GAP. loss of function renders patients susceptible to tumors including NF1-/- benign neurofibromas, can transform into atypical neurofibromas with and CDKN2A loss, then lethal malignant peripheral nerve sheath NF1. CDKN2A, PRC2 component loss. are also many sporadic cancers. known increase or prolong wild type RAS activation, but relative contribution paralogs...