A5034362829- Neurofibromatosis and Schwannoma Cases
- Neuroblastoma Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Nerve injury and regeneration
- Neuropeptides and Animal Physiology
- Glioma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Axon Guidance and Neuronal Signaling
- Cancer Cells and Metastasis
- Meningioma and schwannoma management
- Wnt/β-catenin signaling in development and cancer
- Tissue Engineering and Regenerative Medicine
- Metabolomics and Mass Spectrometry Studies
- Bone Tumor Diagnosis and Treatments
- Advanced MRI Techniques and Applications
- Hippo pathway signaling and YAP/TAZ
- Cellular Mechanics and Interactions
- Multiple Myeloma Research and Treatments
- Microtubule and mitosis dynamics
- Peptidase Inhibition and Analysis
- Spectroscopy Techniques in Biomedical and Chemical Research
- Alzheimer's disease research and treatments
- Peripheral Neuropathies and Disorders
- Amyotrophic Lateral Sclerosis Research
- Thyroid Cancer Diagnosis and Treatment
Cincinnati Children's Hospital Medical Center
2019-2025
University of Cincinnati
2019
Hunter Medical Research Institute
2014-2016
University of Newcastle Australia
2014-2016
University of Wollongong
2015
Illawarra Health and Medical Research Institute
2015
Bio-Medical Science (South Korea)
2015
Institute of Biomedical Science
2015
Amyotrophic Lateral Sclerosis is characterized by a focal onset of symptoms followed progressive spread pathology that has been likened to transmission infectious prions. Cell-to-cell SOD1 protein aggregates dependent on fluid-phase endocytosis pathways, although the precise molecular mechanisms remain be elucidated. We demonstrate in this paper interact with cell surface triggering activation Rac1 and subsequent membrane ruffling permitting aggregate uptake via stimulated macropinocytosis....
// Séverine Roselli 1, 2 , Jay Pundavela Yohann Demont 3, 5 Sam Faulkner Sheridan Keene John Attia 2, 4 Chen Jiang Xu Dong Zhang Marjorie M. Walker Hubert Hondermarck 1 School of Biomedical Sciences & Pharmacy, Faculty Health and Medicine, University Newcastle, Callaghan NSW 2308, Australia Hunter Medical Research Institute, New Lambton 2305, 3 INSERM U908, IFR-147, Universite Lille Villeneuve d'Ascq 59655, France Public U1138, Equipe 11, Centre de Recherche des Cordeliers, Paris 75006,...
Plexiform neurofibroma is a major contributor to morbidity in patients with neurofibromatosis type I (NF1). Macrophages and mast cells infiltrate neurofibroma, data from mouse models implicate these leukocytes development. Antiinflammatory therapy targeting cell populations has been suggested as means prevent Here, we compare gene expression Nf1-mutant nerves, which invariably form show disruption of neuron–glial interactions immune infiltration models, rarely progresses or without...
Plexiform neurofibromas (PNFs) are nerve tumors caused by loss of NF1 and dysregulation RAS-MAPK signaling in Schwann cells. Most PNFs shrink response to MEK inhibition, but targets with increased durable effects needed. We identified the anaphylatoxin C5a as expressed largely PNF m acrophages. defined pharmacokinetic immunomodulatory properties a C5aR1/2 antagonist tested if peptide antagonists augment inhibition. inhibition recruited C5AR1 macrophage surface; short-term C5aR elevated...
The precursor for nerve growth factor (proNGF) is expressed in some cancers but its clinicopathological significance unclear. present study aimed to define the of proNGF thyroid cancer. ProNGF expression was analysed by immunohistochemistry two cohorts cancer versus benign tumors (adenoma) and normal tissues. In first cohort (40 cancers, 40 adenomas 80 tissues), found overexpressed compared samples (p<0.0001). area under receiver-operating characteristic (ROC) curve 0.84 (95% CI 0.75-0.93,...
Plexiform neurofibroma (PNF) is an immune cell-rich peripheral nerve sheath tumor that develops primarily in individuals with Neurofibromatosis Type 1 (NF1). Granulocyte-macrophage colony stimulating factor receptor-β (GM-CSFR-βc) a shared component of receptors for the cytokines GM-CSF, IL-3, and IL-5, ligands immunomodulatory promoting roles. In present study, we use genetically engineered mouse model neurofibroma. We identified expression GM-CSFR-βc GM-CSFR-α on PNF cells macrophages...
Plexiform neurofibromas (PNFs) are benign nerve tumors driven by loss of the NF1 tumor suppressor in Schwann cells. PNFs rich immune cells, but whether cells necessary for tumorigenesis is unknown. We show that inhibition stimulator interferon gene (STING) reduces plasma CXCL10, T cell and dendritic (DC) recruitment, formation. Further, mice lacking XCR-1 + DCs showed reduced tumor-infiltrating PNF tumors. Antigen-presenting from tumor-bearing promoted CD8 proliferation vitro, expressed high...
<b>Abstract ID 98867</b> <b>Poster Board 249</b> Mutations in the NF1 tumor suppressor gene, which encodes a negative regulator of RAS signaling cascades, predispose affected individuals to manifestations including development benign nerve tumors (neurofibromas). The formation and growth plexiform neurofibroma (PNF) depend on interplay between cells surrounding microenvironment (TME), is marked by chronic inflammation, myeloid cell expansion, remodeling local systemic immune compartments....
Neurotrophins are growth factors primarily described in the development of nervous system. They secreted by developing organs to attract nerve fibres, acting as molecular mediators for establishment connections with Recent evidence demonstrates that mammary cells synthesize neurotrophins; however, variation their expression is poorly understood. In this study, we examined a panel key neurotrophins and receptors normal breast. Rare specimens human resting lactating breast tissue were stained...
Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive, nerve-associated and the main cause of death amongst neurofibromatosis type I (NF1) patients. Schwann cells (SCs) pathogenic cell in MPNST, however secretome human MPNST -derived SCs is poorly defined. In this study, a comprehensive proteomic analysis proteins secreted by sNF96.2 SC line, derived from patient with was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). A total 17,354 unique...
Abstract The membrane protein sortilin is involved in intracellular trafficking and has emerged as a key player the regulation of neuronal viability function. Few studies have suggested that may also be implicated cancer, but its expression human tumors potential value therapeutic target unknown. In this study, level was analyzed series 318 clinically annotated breast cancers 53 normal adjacent tissues by immunohistochemistry. Sortilin specifically localized epithelial cells detected 65%...
Abstract Neurofibromatosis Type I (NF1) is a common genetic disorder caused by mutations in the NF1 gene, which encodes RAS-GAP. loss of function renders patients susceptible to tumors including NF1-/- benign neurofibromas, can transform into atypical neurofibromas with and CDKN2A loss, then lethal malignant peripheral nerve sheath NF1. CDKN2A, PRC2 component loss. are also many sporadic cancers. known increase or prolong wild type RAS activation, but relative contribution paralogs...
Abstract Plexiform neurofibroma is a major contributor to morbidity in neurofibromatosis type I (NF1) patients. Macrophages and mast cells infiltrate neurofibroma, data from mouse models implicate these leukocytes development. Anti-inflammatory therapy targeting cell populations has been suggested as means prevent Here, we compare gene expression inflamed nerves NF1 that invariably form those with inflammation driven by EGFR overexpression, which rarely progresses neurofibroma. We find the...