A5057576840- MicroRNA in disease regulation
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Burn Injury Management and Outcomes
- Hernia repair and management
- Cancer, Lipids, and Metabolism
- Advanced Nanomaterials in Catalysis
- Renal function and acid-base balance
- Extracellular vesicles in disease
- Thyroid Cancer Diagnosis and Treatment
- Electrolyte and hormonal disorders
- Intestinal and Peritoneal Adhesions
- Epigenetics and DNA Methylation
- Biomarkers in Disease Mechanisms
- Bioactive natural compounds
- Sodium Intake and Health
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Analysis
- Folate and B Vitamins Research
- Sulfur Compounds in Biology
- Cancer-related gene regulation
XinHua Hospital
2008-2024
Shanghai Jiao Tong University
2013-2024
GTx (United States)
2020
Massachusetts General Hospital
2003-2013
Harvard University
2013
Resistance to cisplatin (DDP) remains a major obstacle in the control of gastric cancer (GC) progression. A previous study revealed that microRNA-21 (miR-21) contributes DDP resistance GC cells via phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway. The aim current was explore mechanisms underlying cytoprotective function miR-21. In this study, DDP-resistant were obtained by continuous exposure human adenocarcinoma increasing concentrations DDP. Western blot analysis used...
Abstract The combination of photothermal therapy (PTT) and photodynamic (PDT) has attracted attention due to its enhanced tumor effect. This study proposes a novel nanoenzyme-based theranostic nanoplatform, IrO 2 @MSN@PDA-BSA(Ce6), for the combined PTT PDT tumors. was prepared by simple hydrolysis method coated with thin layer mesoporous silica (MSN) facilitate physical adsorption Chlorin e6 (Ce6). PDA coating NPs nanoplatform demonstrated an improved conversion efficiency 29.8% under NIR...
The characteristics of poor pharmacokinetics, stability, and low solubility seriously limited the clinical application resveratrol (Res) in breast cancer. Thus, this study intends to develop a delivery system for Res which could be better used cancer therapy.Resveratrol-modified mesoporous silica nanoparticles (MSN-Res) were chemically constructed. Their shape encapsulation detected by transmission electron microscope, Fourier transforms infrared spectrometer, UV spectroscopy, respectively....
To investigate the diagnostic potentials of microRNA-451(miR-451) in papillary thyroid carcinoma (PTC) diagnosis and lymph node (LN) metastasis, formalin-fixed, paraffin-embedded (FFPE) tissue specimens corresponding to PTC tumors (n= 60) their normal counterparts (Normal tissues Adjacent Tumor, NAT, n= 60), along with sera from patients malignant 70) benign lesions were analyzed for expression miR-451 by real-time PCR.The usefulness as a prognostic marker malignancies was evaluated Receiver...
Gallbladder cancer (GBC) is commonly regarded as one of the most lethal malignant tumor types with poor prognosis. Kinesin family member 15 (KIF15) reported to be tightly related progression multiple which, however, has not been clarified in GBC so far. KIF15 was significantly up-regulated clinical tissues compared that para-carcinoma and expression level also correlated malignancies. In addition tissues, cells exhibited a high abundance KIF15. After down-regulating via lentiviral...
MicroRNAs (miRNAs) are small non-coding RNAs which play important roles in the carcinogenesis of gastric cancer (GC). Expression profiling miRNAs paired and adjacent normal tissues has demonstrated that miR-4455 is down-regulated tissues, but its functional role GC had not previously been investigated. The purpose this study was to investigate biological mechanisms progression GC, vitro. compared human tissue samples samples. vitro effects expression MGC-803 cells on their proliferation,...
Gallbladder cancer (GBC), the sixth most common gastrointestinal tract cancer, poses a significant disease burden in China. However, no national representative data are available on clinical characteristics, treatment and prognosis of GBC Chinese population.The Research Group Cancer (CRGGC) study is multicentre retrospective registry cohort study. Clinically diagnosed patient with will be identified from 1 January 2008 to December, 2019, by reviewing electronic medical records 76 tertiary...
Like most of the strategies for cancer immunotherapy, photodynamic therapy-mediated vaccination has shown poor clinical outcomes in application. The aim this study is to offer a glimpse at mechanisms that are responsible failure based on immuno-editing theory and search positive solution. In we found tumor cells were able adapt themselves immune pressure exerted by vaccination. survived exhibited enhanced tumorigenic stem-like phenotypes as well undermined immunogenicity. Viewed whole,...
Associations of High-density lipoprotein (HDL) cholesterol, low-density (LDL) total cholesterol (CHL), and triglyceride (TRG) concentrations with risk biliary tract cancer (BtC) were conflicting in observational studies. We aim to investigate the causal link between circulating lipids BtC using genetic information.
The pathogenesis of colorectal cancer remains poorly understood. Here, we show that coactivator-associated arginine methyltransferase 1 is frequently upregulated in tissues and promotes cell growth vitro vivo. Using bioinformatics-based prediction luciferase reporter system, found post-transcriptionally targeted by microRNA-195-5p cancer. Ectopic expression led to the suppression 3'-untranslated regions activity downregulation endogenous protein cells. Expression analysis verified was...
Obturator hernia is rare type of abdominal and its diagnosis usually made intraoperatively for bowel obstruction or computed tomography (CT) scans the abdomen. The aim this study was to review patient's records with respect clinical manifestation, CT scan findings, operative outcomes.From April 2009 January 2015, six female patients incarcerated obturator underwent urgent operation acute intestinal obstruction. medical were reviewed findings outcomes operation.The median age 83 years (range,...
Hemangioma (HA) is a type of benign tumor common in infancy. The main feature HA the abnormal proliferation vascular endothelial cells. To date, pathogenesis remains unclear. Fully understanding process tumorigenesis essential for developing novel treatment HAs. Dysregulation microRNAs (miRNAs/miR) has been reported to be involved development various diseases, including HA. In present study, expression miR‑424 decreased HA‑derived cells (HemECs). elucidate role HAs development, study...
Prognostic significance of regional lymphadenectomy in T1b gallbladder cancer: Results from 24 hospitals China
Folic acid supplementation may meliorate cardiovascular disease risk by improving vascular endothelial structure and function. However, the underlying mechanisms are still lack of a global understanding. To be used, folic must converted to 7,8-dihydrofolate dihydrofolate reductase generate one-carbon derivatives serving as important cellular cofactors in synthesis nucleotides amino acids required for cell growth. Therefore, this study explored effect knockdown on EA.hy926 growth mechanism...
Background and Objectives:One-stage laparoscopic management for common bile duct stones in patients with gallbladder has gained wide acceptance. We developed a novel technique using transcystic approach exploration as an alternative to the existing procedures.Methods:From April 2010 June 2012, 9 consecutive diagnosed cholelithiasis were enrolled this study. The main inclusion criteria included no upper abdominal surgical history presence of stone measuring <5 mm. After was dissected free...
Severe burn injury evokes hypermetabolism and muscle wasting, despite nominally adequate nutrition. Although there is much information on whole organism isolated tissue metabolism after injury, data examining regional in vivo are lacking. Using surgically implanted (general anesthesia) vascular catheters primed constant infusion of l-[1- 13 C]phenylalanine tracer, we have determined burn-induced alterations rabbit hindquarter protein energy metabolism. Burn increased body resting expenditure...
Previous studies from our laboratories revealed a reduced rate of whole-blood (WB) glutathione (GSH) synthesis in severely burned patients. To determine whether WB GSH metabolism is an indicator the status one or more major organs, we used burn rabbit model to concentrations and rates WB, liver, lungs, kidney, skeletal muscle. L-[1-(13)C]-cysteine was infused intravenously for 6 h rabbits at 3 days post-burn sham controls. organ (13)C-enrichment cysteine determined by gas chromatography/mass...
<title>Abstract</title> Purpose Chloride, the predominant anion in extracellular fluid from humans, is essential to maintaining homeostasis. One important metric for thoroughly assessing kidney function estimated glomerular filtration rate (eGFR). However, relationship between variations serum chloride concentration and eGFR general populations has been poorly studied. Therefore, purpose of this study elucidate correlation plasma levels within United States’ adult population. Methods This...
Chloride, the predominant anion in extracellular fluid from humans, is essential to maintaining homeostasis. One important metric for thoroughly assessing kidney function estimated glomerular filtration rate (eGFR). However, relationship between variations serum chloride concentration and eGFR general populations has been poorly studied. Therefore, purpose of this study elucidate correlation levels within United States' adult population.
The use of the traditional xenograft subcutaneous tumor model has been contested because its limitations, such as a slow tumorigenesis, inconsistent chemotherapeutic results, etc. In light these challenges, we aim to revamp by employing an electrospun scaffold composed polydioxanone, gelatin and elastin boost tumorigenesis. featured highly porous microstructure successfully supported growth cells in vitro without provoking apoptosis. vivo studies showed that volume increased 43.27% weight...
BACKGROUND:MicroRNAs (miRNAs) are novel biomarkers that important in tumorigenesis and cancer treatment resistance. miR-451 is expressed human papillary thyroid carcinoma (PTC) tissues associated with tumor progression. This study investigated the molecular mechanism effects of on B-CPAP PTC cells vitro. MATERIAL AND METHODS:Binding miRNAs to 3’ untranslated region (3’UTR) messenger RNA (mRNA) was determined a luciferase reporter assay. plasmids were transfected into Lipofectamine 2000...