A5070681631- Cholangiocarcinoma and Gallbladder Cancer Studies
- Autism Spectrum Disorder Research
- Maternal Mental Health During Pregnancy and Postpartum
- Gallbladder and Bile Duct Disorders
- Pregnancy and Medication Impact
- Child Development and Digital Technology
- Pancreatic and Hepatic Oncology Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genetics and Neurodevelopmental Disorders
- Cardiovascular Issues in Pregnancy
- Nutritional Studies and Diet
- Per- and polyfluoroalkyl substances research
- Tracheal and airway disorders
- Autophagy in Disease and Therapy
- Breastfeeding Practices and Influences
- Cancer, Stress, Anesthesia, and Immune Response
- Genetic factors in colorectal cancer
- Attention Deficit Hyperactivity Disorder
- Infant Development and Preterm Care
- Metastasis and carcinoma case studies
- Cancer-related molecular mechanisms research
- Anesthesia and Pain Management
- Inflammatory Biomarkers in Disease Prognosis
- S100 Proteins and Annexins
- Diet and metabolism studies
XinHua Hospital
2018-2025
Shanghai Jiao Tong University
2007-2025
First Affiliated Hospital of Chengdu Medical College
2023
Aarhus University Hospital
2022
Aarhus University
2021-2022
Case Western Reserve University
2022
Renji Hospital
2020-2021
State Key Laboratory of Oncogene and Related Genes
2021
Peking University People's Hospital
2018
Peking University
2018
Aberrant expression of lysyl oxidase-like 1 (LOXL1) reportedly leads to fibrous diseases. Recent studies have revealed its role in cancers. In this study, we observed an elevated level LOXL1 the tissues and sera patients with intrahepatic cholangiocarcinoma (ICC) compared levels nontumor unaffected individuals. Overexpression RBE 9810 cell lines promoted proliferation, colony formation, metastasis vivo vitro induced angiogenesis. contrast, depletion showed opposite effects. We further that...
Abstract Apart from primary tumor development and metastasis, cancer-associated thrombosis is the second cause of cancer death in solid malignancy. However, mechanistic insight into gallbladder (GBC) remains unclear. This study aimed to investigate role Sciellin (SCEL) GBC cell proliferation venous thromboembolism. The expression level SCEL was determined by immunohistochemical staining. Roles were molecular biology methods. markedly upregulated associated with advanced TNM stages a poor...
Soy isoflavones are natural tyrosine kinase inhibitors closely associated with decreased morbidity and mortality of various tumors. The activation kinases such as ERBB2 is the mechanism by which cholecystitis transforms into gallbladder cancer (GBC), therefore, it important to investigate relationship between long-term exposure soy occurrence progression GBC. This case-control study (n = 85 pairs) found that high level plasma isoflavone-genistein (GEN) was a lower risk (≥326.00 ng/mL...
Emerging evidence has shown that miR-1275 plays a critical role in tumour metastasis and the progression of various types cancer. In this study, we analysed mechanism prognosis gastric cancer (GC).Target genes were identified verified by luciferase assay Western blotting. The function invasion was vitro vivo nude mice. signal pathway regulated examined qRT-PCR, blotting chromatin immunoprecipitation analyses. expression miR-1275and JAZF1 measured specimens GC adjacent non cancerous...
Cordycepin, the main active ingredient of a traditional Chinese herbal remedy - extracted from Cordyceps sinensis has been demonstrated as very effective anti-inflammatory and antitumor drug. The present study investigated its effect on pancreatic cancer, highly aggressive cancer with extremely poor prognosis due to malignancy, clarified underlying mechanism both in vitro vivo.The viability cordycepin human MIAPaCa-2 Capan-1 cells was determined by colony formation assays. Annexin V/PI...
Previous retrospective studies demonstrated both one-stage and two-stage video-assisted thoracic surgery (VATS) for bilateral pulmonary nodules were safe feasible in selected patients. However, prospective data is still lacking. The purpose of this trial to prospectively compare the prognostic perioperative outcomes between VATS synchronous nodules. We conduct a clinical investigate surgical patients with This plan enroll 198 from single institution during period 5 years. primary outcome...
<title>Abstract</title> Developing children encounter a diverse array of dimensional environmental exposures that collectively shape their brain health. However, studies are mainly limited to single-exposure or single-domain levels. We investigated the comprehensive relationships youth multi-dimensional growth factors with structural signatures, cognitive performance, mental health, and moderation effects genetic components, in over 10,000 US participants from Adolescent Brain Cognitive...
Abstract Background Gallbladder cancer (GBC) is the most common type of biliary tract, and an association has been found between chronic calculous cholecystitis (CCC) increased incidence GBC mortality. An understanding relationship CCC its carcinogenesis may enable us to prevent cure GBC. In this study, we attempted explore changes in microbiome profile that take place during transition from mucosa malignant lesions. Results Seven paired human samples were provided by patients who had...
To investigate the prognostic significance of systemic immune-inflammation index (SII) in patients after radical cholecystectomy for gallbladder cancer (GBC) using overall survival (OS) as primary outcome measure.Based on data from a multi-institutional registry with GBC, significant factors were identified by multivariate Cox proportional hazards model. A novel staging system was established, visualized nomogram. The response to adjuvant chemotherapy compared between different subgroups...
Gallbladder cancer (GBC), the sixth most common gastrointestinal tract cancer, poses a significant disease burden in China. However, no national representative data are available on clinical characteristics, treatment and prognosis of GBC Chinese population.The Research Group Cancer (CRGGC) study is multicentre retrospective registry cohort study. Clinically diagnosed patient with will be identified from 1 January 2008 to December, 2019, by reviewing electronic medical records 76 tertiary...
The first-line chemotherapy regimen for advanced gallbladder cancer (GBC) is gemcitabine plus platinum (GP), despite its efficacy limited. current investigation a retrospective study to compare the safety and between modified FOLFIRINOX (mFOLFIRINOX) oxaliplatin (GEMOX) as unresectable locally or metastatic GBC.The data of patients with GBC, who were treated mFOLFIRINOX GEMOX therapy April 2014 2018 at Xinhua Hospital Affiliated Shanghai Jiaotong University School Medicine, retrieved. This...
Children undergoing surgical anastomosis for long-gap esophageal atresia (LGEA) often suffer from complications related to delayed oral feeding, which may impair their early development. Clinical swallow evaluation (CSE) is an effective technique improve feeding outcomes. However, there are limited evidences on the application of CSE in these children.
Osthole is an antitumor compound, which effect on Gallbladder cancer (GBC) has been not elucidated. This study focused its anti-GBC and mechanism both in vitro vivo. The antiproliferation cell lines NOZ SGC-996 were measured by counting kit-8 (CCK-8) colony formation assay. effects apoptosis cycle investigated flow cytometry migration was checked transwell assay the expressions of proteins examined Western Blots. Also, we did in-vivo experiment intraperitoneal injection osthole nude mice....
Prognostic significance of regional lymphadenectomy in T1b gallbladder cancer: Results from 24 hospitals China
Coagulation and fibrinolysis activation are frequently observed in cancer patients, the tumors these cases thought to be associated with a higher risk of invasion, metastasis worse long-term outcome. The specific aim this study was develop an effective prognostic nomogram help make individualized estimates for patients resected gallbladder (GBC).Patients GBC who were diagnosed between 2006 2014 at Xinhua Hospital selected. Model performance measured by c-index calibration curve. results...
To investigate whether children born to mothers who used carbamazepine during pregnancy had worse academic performance in adolescence.This population-based cohort study included all live-born singletons Denmark between 1996 and 2002 participated the national ninth-grade exit examination (n = 370,859). Those with prescription of antiseizure medications other than were excluded. We examined association utero exposure maternal redeemed 290) offspring, defined by scores Danish mathematics...
Abstract Background COVID-19 lockdowns increased the risk of mental health problems, especially for children with autism spectrum disorder (ASD). However, despite its importance, little is known about protective factors ASD during lockdowns. Methods Based on Shanghai Autism Early Developmental Cohort, 188 two visits before and after strict Omicron lockdown were included; 85 lockdown-free, while 52 51 under longer shorter durations lockdown, respectively. We tested association group clinical...