A5100397822- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Liver Disease Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Mesenchymal stem cell research
- Immune cells in cancer
- Cerebrovascular and Carotid Artery Diseases
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Hepatitis B Virus Studies
- Liver physiology and pathology
- Bone health and osteoporosis research
- Intracranial Aneurysms: Treatment and Complications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Spinal Cord Injury Research
- Immune Cell Function and Interaction
- Hepatitis C virus research
- Moyamoya disease diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- Organ Donation and Transplantation
- Immune Response and Inflammation
- Lung Cancer Research Studies
Third Affiliated Hospital of Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Key Laboratory of Guangdong Province
2021-2024
Human Factors (Norway)
2024
Shanghai Institute of Materia Medica
2024
Chinese Academy of Sciences
2024
University of Chinese Academy of Sciences
2024
Guiyang Medical University
2024
National Medical Products Administration
2023
Abstract Older livers are more prone to hepatic ischaemia/reperfusion injury (HIRI), which severely limits their utilization in liver transplantation. The potential mechanism remains unclear. Here, we demonstrate older exhibit increased ferroptosis during HIRI. Inhibiting significantly attenuates HIRI phenotypes. Mass spectrometry reveals that fat mass and obesity-associated gene (FTO) expression is downregulated livers, especially Overexpressing FTO improves phenotypes by inhibiting...
Abstract In response to infection, polymorphonuclear neutrophils (PMN) are recruited in the infectious sites, and employ three major strategies fight against microbes including phagocytosis, degranulation, neutrophil extracellular traps (NETs). NETs a meshwork of chromatin fibers mixed with granule-derived antimicrobial peptides enzymes, which trap kill bacteria extracellularly. this study, by using mouse sepsis model, we identified novel mechanism induce macrophage (Mϕ) pyroptosis,...
The current staging system of gastric cancer is not adequate for defining a prognosis and predicting the patients most likely to benefit from chemotherapy.To construct survival prediction model based on specific tumor patient characteristics that enables individualized predictions net adjuvant chemotherapy with stage II or III cancer.In this multicenter retrospective analysis, was constructed using data training cohort 746 who satisfied study's inclusion criteria underwent surgery between...
Background and Aims: Immune cells play a crucial role in liver aging. However, the impact of dynamic changes local immune microenvironment on age-related injury remains poorly understood. We aimed to characterize intrahepatic at different ages investigate key mechanisms associated with Approach Results: carried out single-cell RNA sequencing mouse tissues 4 ages, namely, newborn, suckling, young, aged stages. The transcriptomic landscape, cellular classification, intercellular communication...
Spinal cord injury (SCI) is a devastating neurological disease that often results in tremendous loss of motor function. Increasing evidence demonstrates diabetes worsens outcomes for patients with SCI due to the higher levels neuronal oxidative stress. Mammalian sterile 20-like kinase (MST1) key mediator stress central nervous system; however, mechanism its action still not clear. Here, we investigated role MST1 activation induced both and diabetes. Diabetes was established mice by diet...
There is growing evidence that the systemic immune-inflammation index (SII), a novel prognostic biomarker based on peripheral lymphocyte, neutrophil, and platelet counts, associated with poor prognosis for several tumors. However, value of SII in patients hepatocellular carcinoma (HCC) who undergo liver transplantation (LT) remains unclear. The aim this study was to determine correlation between these patients.This retrospective involved 150 HCC underwent LT within Hangzhou criteria. optimal...
The mechanisms responsible for the inhibitory effects of mesenchymal stem cells (MSCs) on dendritic (DCs) are still poorly understood. Our investigation potential signaling pathways revealed first time that human umbilical-cord-derived MSCs (UC-MSCs) instruct DCs to acquire tolerogenic phenotypes through IL-6-mediated upregulation SOCS1. This subset MSC-DCs exhibited a pattern, with clear decrease in expression co-stimulatory molecules and capacity stimulate CD3(+) T cell proliferation...
Abstract Background Pneumonia is the most frequently encountered postoperative pulmonary complications (PPC) after orthotopic liver transplantation (OLT), which cause high morbidity and mortality rates. We aimed to develop a model predict pneumonia in OLT patients using machine learning (ML) methods. Methods Data of 786 adult underwent at Third Affiliated Hospital Sun Yat-sen University from January 2015 September 2019 was retrospectively extracted electronic medical records randomly...
Abstract Apart from primary tumor development and metastasis, cancer-associated thrombosis is the second cause of cancer death in solid malignancy. However, mechanistic insight into gallbladder (GBC) remains unclear. This study aimed to investigate role Sciellin (SCEL) GBC cell proliferation venous thromboembolism. The expression level SCEL was determined by immunohistochemical staining. Roles were molecular biology methods. markedly upregulated associated with advanced TNM stages a poor...
Abstract Cold-induced injuries severely limit opportunities and outcomes of hypothermic therapies organ preservation, calling for better understanding cold adaptation. Here, by surveying cold-altered chromatin accessibility integrated CUT&Tag/RNA-seq analyses in human stem cells, we reveal forkhead box O1 (FOXO1) as a key transcription factor autonomous Accordingly, find nonconventional, temperature-sensitive FOXO1 transport mechanism involving the nuclear pore complex protein RANBP2,...
Hidden haemorrhage has been proved to be significant in joint surgery. However, when referring lumbar interbody fusion, it is often ignored because of its invisibility. This randomized controlled study aimed calculate and compare hidden following minimally invasive open transforaminal fusion (MIS-TLIF TLIF). Meanwhile, clinical significance was also analyzed.A total 41 patients were included this study, then they receive MIS-TLIF or TLIF, 21 20, respectively. For each case, volume loss red...
Abstract Background ABO-incompatible liver transplantation (ABO-i LT) has become a rescue therapeutic option for patients with severe hepatic failure. Although the use of rituximab greatly reduces morbidity antibody-mediated rejection (AMR), adverse effects, such as infection and biliary complications, still seriously threaten survival transplant recipients. The aim this study was to evaluate safety feasibility using mesenchymal stem cells (MSCs) replace in ABO-i LT. Methods Twenty-two...
Accumulating evidence shows a close association between various types of bile acids (BAs) and hepatocellular carcinoma (HCC), they have been revealed to affect tumor immune response progression mainly by regulating Farnesoid X receptor (FXR). Nevertheless, the roles Norcholic acid(NorCA) in HCC remain unknown yet. In this study, herein we demonstrate that NorCA can promote cell proliferation, migration invasion through negatively FXR. Additionally, increase PD-L1 level on surfaces cells...
Pulmonary vascular remodeling (PVR), encompassing microvascular loss and muscularization, contributes to multiple respiratory diseases. c-Kit+ cells exhibit differentiation potential into both endothelial (ECs) smooth muscle cells. The role of lung cell in PVR, however, remains unclear. Lung increase pulmonary hypertension patients the SU5416/hypoxia (SuHx)-induced PVR mouse model. Employing genetic lineage tracing single-cell RNA sequencing (scRNA-seq), we elucidate that lung-resident...
ABSTRACT Hepatic ischemia–reperfusion injury (HIRI) substantially influences the prognosis of liver transplant recipients. Although kynurenic acid (KYNA) has been associated with protective effects against in various organs, precise mechanisms underlying its role HIRI are not well elucidated. In this study, a 70% mouse model and an vitro hypoxia/reoxygenation were employed to examine KYNA on HIRI. we illustrate that methylation status Hippo signalling pathway by enhancing expression fat mass...