A5100344222- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Inflammatory Biomarkers in Disease Prognosis
- Liver physiology and pathology
- Extracellular vesicles in disease
- Hippo pathway signaling and YAP/TAZ
- Gallbladder and Bile Duct Disorders
- Cancer-related gene regulation
- Advanced biosensing and bioanalysis techniques
- Bone and Joint Diseases
- Lipid metabolism and biosynthesis
- Mitochondrial Function and Pathology
- RNA Interference and Gene Delivery
- Viral-associated cancers and disorders
- Pregnancy and Medication Impact
- Immunotherapy and Immune Responses
- Adenosine and Purinergic Signaling
- Bone health and treatments
- Phagocytosis and Immune Regulation
Sun Yat-sen University
2016-2025
Sun Yat-sen University Cancer Center
2025
Shanghai Jiao Tong University
2025
Shenyang Pharmaceutical University
2025
Third Affiliated Hospital of Sun Yat-sen University
2014-2024
Human Factors (Norway)
2024
Key Laboratory of Guangdong Province
2019-2023
Xuzhou Medical College
2014-2022
Second People’s Hospital of Huai’an
2022
Xiang Yang No.1 People's Hospital
2020
Peroxisome proliferator-activated receptor α (PPARα, NR1C1) is a ligand-activated nuclear involved in the regulation of lipid catabolism and energy homeostasis. PPARα activation induces hepatomegaly plays an important role liver regeneration, but underlying mechanisms remain unclear.In this study, effect on enlargement regeneration was investigated several strains genetically modified mice. by specific agonist WY-14643 significantly induced accelerated after 70% partial hepatectomy (PHx)...
Background Neutrophil to lymphocyte ratio (NLR) has been proposed predict prognosis of hepatocellular carcinoma (HCC). However, the cut-off values are empirical. We determined optimal value HCC recurrence after liver transplantation (LT) and further established a scoring model based on NLR. Methodology/Principal Findings analyzed outcome 101 HBV-associated patients undergoing LT. Preoperative risk factors for tumor were evaluated by univariate analysis. By using ROC analysis, NLR≥3 was...
Diabetic nephropathy (DN) is one of the most severe and frequent diabetic complications. MicroRNAs (miRNAs) have been reported to play a vital role in DN pathogenesis. The present study aimed investigate molecular mechanism miR-770-5p DN.Podocyte injury model was established by treating mouse podocytes with high glucose (HG, 33 mM) for 24 h. levels TIMP3 were examined kidney tissues using quantitative real-time PCR (qRT-PCR). Flow cytometry analysis applied detect apoptosis podocytes....
Abstract Protein induced by vitamin K absence or antagonist II (PIVKA-II) plays a critical role in the diagnosis of hepatocellular carcinoma (HCC), however, studies on its efficacy diagnosing recurrent HCC were rarely found. A multicenter, retrospective, and observational study was conducted. During overall follow-up 5 years, patients who had curative resection monitored every 3 months first year post-surgery 6 thereafter if no recurrence occurred. Tumor markers collected at for those with...
The constitutive androstane receptor (CAR, NR3I1) belongs to nuclear superfamily. It was reported that CAR agonist TCPOBOP induces hepatomegaly but the underlying mechanism remains largely unknown. Yes-associated protein (YAP) is a potent regulator of organ size. aim this study explore role YAP in activation-induced and liver regeneration. TCPOBOP-induced activation on regeneration evaluated wild-type (WT) mice, liver-specific YAP-deficient partial hepatectomy (PHx) mice. results demonstrate...
Hepatic ischemia-reperfusion (I/R) injury fundamentally influences the performance of aged liver grafts. The significance mitophagy in age dependence sensitivity to I/R remains poorly understood. Here, we show that aging aggravated hepatic with decreased mice. enhancement resulted significant protection against injury. Parkin, an E3 ubiquitin ligase, was found depleted by livers. In oxygen-glucose deprivation reperfusion (OGD-Rep.)-treated L02 cells, parkin silencing impaired and cell damage...
To observe the effect of intelligent management mode cardiac rehabilitation in patients with coronary artery bypass grafting. From May 2023 to October 2024, 70 grafting our hospital were selected and divided into two groups according random sampling grouping method. One group carried out routine (35 cases, control group), other observation group). The function level, exercise endurance self-care ability during recovery compared. level was higher than that group, P
Activatable cell-penetrating peptides (aCPPs) allow non-viral, low cytotoxic and selective delivery of compounds into target cells for cancer therapy. In tumour cells, up-regulation human telomerase reverse transcriptase (hTERT) frequently occurs is being considered as a in diagnosis treatment. siRNA sequence that hTERT mRNA can silence the gene reduce protein expression to cell proliferation inhibit growth. our study, we tested matrix metalloproteinase-2 (MPP2) aCPP delivering...
Background & AimsImmunosuppression-related symptom experience has not been covered thoroughly in long-term liver transplant recipients. The aim of this study was to assess the immunosuppressive therapy three years after transplantation and correlate it with adherence medications sociodemographic or disease-related characteristics. MethodsThis included 94 recipients who had survived for more than 3 transplantation. Symptom measured by 59-Item Modified Transplant Occurrence Distress Scale...
Primary hepatic neuroendocrine tumors (PHNETs) are rare malignant liver that present diagnostic challenges owing to their rarity and absence of specific clinical features. This study aimed investigate the characteristics this tumor enhance our understanding disease, improve accuracy, explore standardized treatment approaches.During physical examination, two elderly women, aged 64 74 years, were found have masses. 18F-FDG Positron Emission Tomography-Computed Tomography (18F-FDG PET-CT)...
Gene silencing in liver disease could be achieved by delivering siRNA with nonviral vectors. However, the transfection efficiency of plasmid ( psiRNA) applied through this approach hepatocytes is generally low. Based on fact that asialoglycoprotein receptors present can recognize galactose, we synthesized galactosylated poly(ethylene glycol)-graft-polyethylenimine (Gal-PEG-PEI) as a psiRNA carrier for hepatocyte targeting. Our results indicate 0.2% (molar percentage) amine groups PEI was...
Immunosuppressant-related hip pain can greatly affect a patient's mobility and increase the number of total arthroplasties. We investigated risk factors causes after orthotopic liver transplant.The medical records 175 adult transplant patients, who were followed-up for more than 2 years, retrospectively reviewed. Data collected from included primary disease, medications, biochemical results, Child-Turcotte-Pugh score, death, rejection, complications related to transplant.A 11 patients (6.3%)...
Inadequate remnant volume and regenerative ability of the liver pose life-threatening risks to patients after partial transplantation (PLT) or hepatectomy (PHx), while few clinical treatments focus on safely accelerating regeneration. Recently, we discovered that supplementing 5-aminolevulinate (5-ALA) improves cold adaptation functional recovery, leading us uncover a correlation between 5-ALA metabolic activities post-PLT recovery. In mouse 2/3 PHx model, supplements enhanced regeneration,...
Whether hepatic resection (HR) could be performed for patients with Barcelona Clinic Liver Cancer (BCLC) B/C stage hepatocellular carcinoma (HCC) is controversial, and the safety clinical value of HR combined antiviral therapy hepatitis B virus (HBV)-related HCC BCLC-B/C remain to investigated. We retrospectively evaluated 126 BCLC who underwent HR. These were divided into group (Group A, n = 86) control B, 40). The operative indications prognosis analyzed. 1-year, 3-year, 5-year...
Aim: To determine whether donor immature dendritic cells (imDCs) combined with a short postoperative course of rapamycin (Rapa) has the ability to expand CD4 + CD25 Foxp3 regulatory T (Treg) and prolong liver allograft survival. Methods: Orthotopic transplantation (OLT) was performed from Lewis rats Brown Norway recipients. Three days before transplantation, animals were injected intravenously 2 × 10 6 bone marrow‐derived imDCs. Recipient (the treated group) also received Rapa for 7 d after...
Background and AimsHepatic ischemia-reperfusion injury (HIRI) is a prevalent complication of liver transplantation, partial hepatectomy, severe infection, necessitating the development more effective clinical strategies. Receptor activity–modifying protein 1 (RAMP1), member G protein–coupled receptor adapter family, has been implicated in numerous physiological pathological processes. The study aimed to investigate pathogenesis RAMP1 HIRI.