A5100462258- Aquaculture disease management and microbiota
- interferon and immune responses
- Mycobacterium research and diagnosis
- Bacteriophages and microbial interactions
- Geographic Information Systems Studies
- Cardiovascular Function and Risk Factors
- Psoriasis: Treatment and Pathogenesis
- Toxin Mechanisms and Immunotoxins
- Monoclonal and Polyclonal Antibodies Research
- ZnO doping and properties
- Organ Transplantation Techniques and Outcomes
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cell death mechanisms and regulation
- Amyotrophic Lateral Sclerosis Research
- E-commerce and Technology Innovations
- Cell Adhesion Molecules Research
- Ear Surgery and Otitis Media
- Ga2O3 and related materials
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mosquito-borne diseases and control
- Data Management and Algorithms
- Transplantation: Methods and Outcomes
- Selenium in Biological Systems
- Advanced Glycation End Products research
Yichun University
2024-2025
Wuhan University
2025
Renmin Hospital of Wuhan University
2025
Shandong First Medical University
2023-2024
National Cheng Kung University
2024
Academia Sinica
2024
Institute of Molecular Biology, Academia Sinica
2024
The University of Texas MD Anderson Cancer Center
2024
Shanghai Ocean University
2024
China University of Geosciences
2023
The mechanisms responsible for the inhibitory effects of mesenchymal stem cells (MSCs) on dendritic (DCs) are still poorly understood. Our investigation potential signaling pathways revealed first time that human umbilical-cord-derived MSCs (UC-MSCs) instruct DCs to acquire tolerogenic phenotypes through IL-6-mediated upregulation SOCS1. This subset MSC-DCs exhibited a pattern, with clear decrease in expression co-stimulatory molecules and capacity stimulate CD3(+) T cell proliferation...
Abstract Severe infection commonly results in immunosuppression, which leads to impaired pathogen clearance or increased secondary both humans and animals. However, the exact mechanisms remain poorly understood. Here, we demonstrate that IL-33 immunosuppression by inducing thymic involution-associated naive T cell dysfunction with aberrant expression of aging-associated genes impairs host control mouse disease models schistosomiasis sepsis. Furthermore, illustrate triggers excessive...
Otosclerosis is a progressive hearing loss characterized by an abnormal bone homeostasis of the otic capsule that leads to stapes fixation. Although its etiology remains unknown, otosclerosis can be considered complex disease. Transforming growth factor-beta 1 (TGF-β1) was chosen for case–control association study, because several non-genetic indications involvement in otosclerosis. Single nucleotide polymorphism (SNP) analysis large Belgian–Dutch sample set gave significant results ( P =...
The discovery of pathogenic variants provided biological insight into the role host genetic factors in generalized pustular psoriasis (GPP). However, not all those affected by GPP carry reported genes. To comprehensively explore molecular pathogenesis GPP, whole-exome sequencing was performed, and two loci were identified with exome-wide significance through single variant association analysis: rs148755083 IL36RN gene (Pcombined = 1.19 × 10-18, OR 8.26) HLA-C∗06:02 within major...
Recent studies have shown that the hydrogels formed by composite biomaterials are better choice than single biomaterial for tissue repair. We explored feasibility of hydrogel silk fibroin (SF) and sericin (SS) in repair excellent mechanical properties SF, cell adhesion biocompatible SS. In our study, SF SS was protein with separate extraction method (LiBr dissolution hot alkaline water SS), while SF-SS using simultaneous protein). The effects two on release inflammatory cytokines from...
In this paper, high-quality β-Ga2O3 films were grown on silicon substrates by plasma-enhanced atomic layer deposition (PEALD). Effects of annealing temperature thin studied. Atomic force microscopy (AFM), X-ray diffraction (XRD), photoelectron spectroscopy (XPS), reflection (XRR), and ultraviolet (UV) emission used to systematically characterize Ga2O3 films. AFM test results showed that as increased from 500 900 °C, the roughness film 0.542 1.58 nm. XPS concentration oxygen vacancies in...
Abstract Pityriasis rubra pilaris (PRP) is an inflammatory papulosquamous dermatosis, characterized by hyperkeratotic follicular papules and erythematous desquamative plaques. The precise pathogenic mechanism underlying PRP remains incompletely understood. Herein, we conduct a case-control study involving cohort of 102 patients with sporadic 800 healthy controls Han Chinese population identify significant associations ( P = 1.73 × 10 −6 ) between heterozygous mutations in the Keratin 32 gene...
Diabetic cardiomyopathy is characterized by an imbalance between myocyte death and regeneration mediated the progressive loss of cardiac stem progenitor cells (CSPCs) apoptosis necrosis due to activation oxidative stress with diabetes. In this study, we evaluated beneficial effect astragalus polysaccharides (APS) therapy on protection CSPCs through its antioxidative capacity in diabetic hearts.Streptozotocin (STZ)-induced mice heterozygous (SOD2+/-) knockout were employed administered APS....
Background: Hepatocellular carcinoma (HCC) has become the world’s primary cause of cancer death. Obesity, hyperglycemia, and dyslipidemia are all illnesses that part metabolic syndrome. In recent years, this risk factor increasingly recognized as a contributing to HCC. Around world, non-alcoholic fatty liver disease (NAFLD) is on rise, especially in western countries. past, exact pathogenesis NAFLD progressed factors (MFRs)-associated HCC not been fully understood. Methods: Two groups GEO...
Abstract Fibronectin (FN) and collagen are vital components of the extracellular matrix (ECM). These proteins essential for tissue formation cell alignment during wound healing stage. In particular, FN interacts with collagens to activate various intracellular signaling pathways maintain ECM stability. A novel recombinant extra domain-B fibronectin (EDB-FN)-COL3A1 fusion protein (rhFEB) was designed mimic promote chronic refractory skin ulcer healing. rhFEB significantly enhanced adhesion...
Abstract Aims To create a consensus on the nursing crisis leadership evaluation system during major infectious disease emergencies. Background Crisis is critical to prevent and mitigate an public health emergency time. However, there has been no for staff diseases emergencies in China. Methods We used two-part modified Delphi method. Part 1 focused creating pool of indicators developing framework through systematic literature review qualitative interview. 2 revised built final using two...
Objective . Oxidant stress plays an important role in the development of diabetic cardiomyopathy. Previously we reported that Astragalus polysaccharides (APS) rescued heart dysfunction and cardinal pathological abnormalities mice. In current study, determined whether effect APS on cardiomyopathy was associated with its impact oxidant stress. Methods Db/db mice were employed administered APS. The hematodynamics, cardiac ultra-structure, apoptosis, ROS formation myocardium assessed. protein...
Nervous necrosis virus (NNV) is the causative agent of viral encephalopathy and retinopathy (VER), a neurological disease responsible for high mortality fish species worldwide. Taking advantage our established Chinese perch brain (CPB) cell line derived from tissues Mandarin (Siniperca chuatsi), susceptibility CPB to Red-Spotted Grouper nervous (RGNNV) was evaluated. The results showed that RGNNV replicated well in cells, resulting cellular apoptosis. Moreover, also Abnormal swimming...