A5101985531- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Effects of Radiation Exposure
- Genetic and Kidney Cyst Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune Cell Function and Interaction
- Dialysis and Renal Disease Management
- Ion Transport and Channel Regulation
- Biomedical Research and Pathophysiology
- Renal and related cancers
- Sirtuins and Resveratrol in Medicine
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Healthcare and Venom Research
- Advanced Glycation End Products research
- Chemotherapy-induced organ toxicity mitigation
- Tissue Engineering and Regenerative Medicine
- Parathyroid Disorders and Treatments
- Cardiovascular Health and Disease Prevention
- Renin-Angiotensin System Studies
- Mesenchymal stem cell research
- Blood Pressure and Hypertension Studies
- Cell death mechanisms and regulation
Renmin Hospital of Wuhan University
2013-2025
Wuhan University
2014-2025
Guangxi University of Chinese Medicine
2023-2024
Peking University Shenzhen Hospital
2018-2024
First Affiliated Hospital of Guangdong Pharmaceutical University
2024
Nanning Normal University
2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Ruijin Hospital
2023
Integrated Chinese Medicine (China)
2023
Previous studies have shown that mitochondrial dysfunction plays an important role in high- glucose(HG)-induced podocyte injury and thus contributes to the progression of diabetic nephropathy(DN). The histone deacetylase Sirtuin6 (Sirt6) has been revealed essential regulation function skeletal muscle cardiomyocytes. However, its specific homeostasis podocytes is undetermined. Here, we aimeds explore physiological Sirt6 mitochondria apoptosis under HG conditions possible mechanism. Herein,...
Significance Necroptosis is a regulated form of necrotic cell death that important in physiology and human diseases. However, the signaling process leading to eventual necroptosis remains unclear. We show PUMA , proapoptotic BH3-only Bcl-2 family member, induced plays role necroptotic death. induction enhances by promoting release mitochondrial DNA activation cytosolic sensors. provide genetic evidence for functional necroptosis-mediated developmental defects mice. Our results demonstrate...
The cellular responses induced by mitochondrial dysfunction remain elusive. Intrigued the lack of almost any glomerular phenotype in patients with profound renal ischemia, we comprehensively investigated primary sources energy podocytes. Combining functional measurements oxygen consumption rates, metabolite analysis, and determination density podocytes vivo, demonstrate that anaerobic glycolysis fermentation glucose to lactate represent key source Under physiological conditions, could detect...
Electrical stimulation (ES) has been shown to promote nerve regeneration when it was applied the proximal stump. However, possible beneficial effect of establishing a local electrical environment between large defect on not reported in previous studies. The present study attempted establish defect, and examined its functional recovery.In study, conductive scaffold constructed used bridge 15 mm sciatic rats, intermittent ES (3 V, 20 Hz) an at site defect. Nerve recovery were after injury...
Abstract Purpose: Regorafenib, a multikinase inhibitor targeting the Ras/Raf/MEK/ERK pathway, has recently been approved for treatment of metastatic colorectal cancer. However, mechanisms action regorafenib in cancer cells have unclear. We investigated how suppresses cell growth and potentiates effects other chemotherapeutic drugs. Experimental Design: determined whether induces expression PUMA, p53 target critical mediator apoptosis cells. also PUMA is necessary killing chemosensitization...
Radiotherapy causes dose-limiting toxicity and long-term complications in rapidly renewing tissues, including the gastrointestinal tract. Currently, there is no FDA-approved agent for prevention or treatment of radiation-induced intestinal injury. In this study, we have shown that PD 0332991 (PD), an selective inhibitor cyclin-dependent kinase 4/6 (CDK4/6), prevents lethal injury mice. Treating mice with a structurally distinct CDK4/6 prior to radiation blocked proliferation crypt apoptosis...
<i>Background/Aim:</i> In in vitro studies, angiotensin (Ang) II has been demonstrated to promote podocyte apoptosis. The present study evaluates the effects of Ang infusion rats on nephrin expression and apoptosis molecular mechanisms involved II-induced proteinuria mesangial expansion. <i>Methods:</i> Sprague-Dawley were randomly assigned receive either normal saline or (400 ng·kg<sup>–1</sup>·min<sup>–1</sup>) by means a mini-osmotic pump...
Abstract Exposure to high levels of ionizing radiation (IR) leads debilitating and dose-limiting gastrointestinal (GI) toxicity. Using three-dimensional mouse crypt culture, we demonstrated that p53 target PUMA mediates radiation-induced apoptosis via a cell-intrinsic mechanism identified the GSK-3 inhibitor CHIR99021 as potent radioprotector. treatment improved Lgr5+ cell survival regeneration after in culture mice. specifically blocked induction K120 acetylation mediated by...
Targeting of p53- and PUMA-dependent apoptosis protects intestinal stem cells, but not cancer against chemotherapy.
Removal of damaged and depolarized mitochondria, known as mitophagy, is critical to cellular homeostasis viability. Although initially identified in neurodegenerative diseases, mitophagy being recognized playing important roles during acute kidney injury. PINK1 Parkin play central regulating mitophagy. Here, we used knockout rats examine the role PINK1/Parkin-mediated cisplatin nephrotoxicity. Compared with wild-type rats, showed lower serum creatinine less tubular damage following...
Epithelial IFN-β couples radiation-induced intestinal stem cell injury with local inflammation and regeneration.
Abstract Background Human major histocompatibility complex class I-related chain A (MICA) plays a dual role in adaptive and innate immune responses. Increasing evidence demonstrates that MICA is closely correlated with acute chronic kidney allograft rejection. Therefore, understanding the activation mechanisms of important transplantation. We previously demonstrated ischemia/reperfusion injury (IRI) could up-regulate expression on mouse allografts. Since hypoxia-inducible factor-1 (HIF-1)...
The M-type phospholipase A2 receptor (PLA2R) is expressed in podocytes human glomeruli. Group IB secretory (sPLA2 IB), which one of the ligands PLA2R, more highly chronic renal failure patients than controls. However, roles PLA2R and sPLA2 pathogenesis glomerular diseases are unknown. In present study, we found that podocyte apoptosis occurs kidneys with higher serum levels. vitro, demonstrated cells cell membrane. After binding induced a time- concentration-dependent manner. IB-induced...
Recent studies have shown that nephrin plays a vital role in angiotensin II (Ang II)-induced podocyte injury and thus contributes to the onset of proteinuria progression renal diseases, but its specific mechanism remains unclear. c-Abl is an SH2/SH3 domain-containing nonreceptor tyrosine kinase involved cell survival regulation cytoskeleton. Phosphorylated able interact with molecules containing domains, suggesting may be downstream molecule signaling. Here we report Ang II-infused rats...
Abstract Our previous study showed that angiotensin II (Ang II) exposure diminished the interaction between nephrin and c-Abl, then c-Abl mediated SHIP2-Akt pathway in process of podocyte injury vivo vitro. However, relationship was unknown. Recently, various studies required for cytoskeletal remodeling glomerular podocytes. But its specific mechanisms remain incompletely understood. As a nonreceptor tyrosine kinase involved regulation, may be candidate signaling proteins interacting with...