A5034283242- MicroRNA in disease regulation
- RNA modifications and cancer
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Cancer-related molecular mechanisms research
- Advanced Breast Cancer Therapies
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Metastasis and carcinoma case studies
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Cancer Treatment and Pharmacology
- Estrogen and related hormone effects
- PARP inhibition in cancer therapy
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Breast Lesions and Carcinomas
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Cancer Risks and Factors
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Metabolism, Diabetes, and Cancer
- Radiomics and Machine Learning in Medical Imaging
Fujian Medical University
2014-2025
Union Hospital
2015-2025
National Cheng Kung University
2019-2025
Shandong University
2011-2024
Beijing Anzhen Hospital
2018-2024
Capital Medical University
2018-2024
Shandong First Medical University
2023-2024
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
Qilu Hospital of Shandong University
2017-2024
<h3>Importance</h3> Prospective assessment of treatments known to benefit patients in global clinical trials specific racial groups is essential. <h3>Objective</h3> To compare the efficacy, safety, and tolerability adding pertuzumab trastuzumab docetaxel vs placebo, trastuzumab, Asian with ERBB2-positive early or locally advanced breast cancer. <h3>Design, Setting, Participants</h3> This multicenter, double-blind, placebo-controlled phase 3 trial enrolled 329 women (T2-3, N0-1, M0) cancer N2...
An association between lymph node metastasis and poor prognosis in breast cancer was observed decades ago. However, the mechanisms by which tumor cells infiltrate lymphatic system are not completely understood. Recently, it has been proposed that an active role metastatic dissemination tumor-secreted growth factors stimulate lymphangiogenesis. We therefore investigated whether SIX1, a homeodomain-containing transcription factor previously associated with positivity, involved...
The notion of personalized medicine demands proper prognostic biomarkers to guide the optimal therapy for an invasive breast cancer patient. However, various risk prediction models based on conventional clinicopathological factors and emergent molecular assays have been frequently limited by either a low strength prognosis or restricted applicability specific types patients. Therefore, there is critical need develop strong general prognosticator.
Pyrotinib (an irreversible pan-ErbB inhibitor) plus capecitabine has survival benefits and acceptable tolerability in patients with HER2-positive metastatic breast cancer. We further assessed addition of pyrotinib to trastuzumab docetaxel the neoadjuvant setting. In this multicenter, double-blind, phase 3 study (PHEDRA), treatment-naive women early or locally advanced cancer were randomly assigned (1:1) receive four cycles oral placebo (400 mg) once daily, intravenous (8 mg/kg loading dose,...
Abstract The randomized, multicenter, double-blind, placebo-controlled, phase III PEONY trial (NCT02586025) demonstrated significantly improved total pathologic complete response (primary endpoint) with dual HER2 blockade in HER2-positive early/locally advanced breast cancer, as previously reported. Here, we present the final, long-term efficacy (secondary endpoints: event-free survival, disease-free overall survival) and safety analysis (62.9 months’ median follow-up). Patients (female; n =...
Mammary-specific overexpression of Six1 in mice induces tumors that resemble human breast cancer, some having undergone epithelial to mesenchymal transition (EMT) and exhibiting stem/progenitor cell features. cancer cells promotes EMT metastatic dissemination. We hypothesized plays a role the tumor initiating (TIC) population specifically certain subtypes by understanding its mechanism action, we could potentially develop new means target TICs.We examined gene expression datasets determine...
Oncogenic KRAS mutations are present in approximately 90% of pancreatic ductal adenocarcinoma (PDAC). However, Kras mutation alone is insufficient to transform precancerous cells into metastatic PDAC. This study investigates how KRAS-mutated epithelial acquire the capacity escape senescence or even immune clearance, thereby progressing advanced Single-cell RNA sequencing and analysis primary PDAC tumors were conducted. Genetically engineered pancreas-specific Kras-mutated, dual specificity...
It was originally thought that no single routine blood test result would be able to indicate whether or not a patient had cancer; however, several novel studies have indicated the median survival and prognosis of cancer patients were markedly associated with systemic circulation features patients. In addition, certain parameters, such as white cell (WBC) count, largely altered in malignant tumors. present study, tests performed order observe change cells tumor-bearing mice following...
Gastric cancer (GC) is one of the most prominent global cancer-related health threats. Genes play a key role in precise mechanisms gastric cancer. SNPs mi-RNAs could affect mRNA expression and then risk prognosis GC. Firstly, we have decided to perform case-control study which included 897 GC patients 992 controls evaluate association miR-219-1 rs213210, miR-938 rs2505901, miR-34b/c rs4938723, miR-218 rs11134527 polymorphisms with susceptibility. Secondly, among above, 755 cases underwent...
Abstract Purpose: A key issue in cancer is apoptosis resistance. However, little known about the transcription factors that contribute to cellular survival of head and neck squamous cell carcinoma (HNSCC). Experimental Design: Three batches (54, 64, 38) HNSCC specimens were used for molecular analyses determine major signaling pathways HNSCC. Animal models (cell culture xenografts) verify importance resistance Results: Inhibitor differentiation (Id) family member, Id1, was significantly...
Solute carrier family 31 member 1(SLC31A1) has been reported as the copper importer, and was identified to be involved in process of "cuproptosis". However, mechanism SLC31A1 breast cancer remains unclear.We examined expression mRNA tissues cell lines using Real-time PCR. The data for this study were obtained from Cancer Genome Atlas (TCGA) database analyzed via R 3.6.3. TIMER, UALCAN, GEPIA2, STRING, Metascape, Kaplan-Meier Plotter, starBase miRNet websites used a comprehensive analysis...
Abstract: The long noncoding RNA (lncRNA) H19 is a maternally expressed imprinted gene that plays important roles in tumorigenesis, progression, and metastasis. However, the association between polymorphisms on breast cancer (BC) susceptibility has remained obscure. In this case–control study, we assessed interaction two lncRNA single-nucleotide (SNPs) (rs217727 C>T, rs2839698 C>T) risk of BC Chinese Han population. total, 1,005 cases 1,020 healthy controls were enrolled study. Correlations...
Hox transcript antisense intergenic RNA (HOTAIR) is a well-known long non-coding (lncRNA) which participates in tumorigenesis and progress of multiple cancers. However, the associations among polymorphisms on HOTAIR, breast cancer (BC) susceptibility clinical outcomes have remained obscure. In this case-control study, we assessed interaction between three lncRNA HOTAIR single nucleotide (SNPs) (rs1899663, rs4759314 rs7958904) risk outcome Chinese Han population. total, 969 cases 970 healthy...
Abstract Background Papillary breast lesions constitute a pathological heterogeneous group and display diverse clinical imaging features. This study was conducted to analyze the upgrade rate of intraductal papilloma diagnosed on core needle biopsy assess possible risk factors associated with higher‐risk lesions. We also examined long‐term outcomes in patients who received resection papillary Materials methods The pathology records 324 female were based (CNB) from February 2010 October 2016...
// Caiqin Mo 2,* , Hailong Lin 3,* Fangmeng Fu 1,* Jie Zhang Meng Huang 4 Chuan Wang 1 Yunjing Xue 3 Qing Duan Weiwen and Xiangjin Chen 2 Department of Breast Surgery, Affiliated Union Hospital Fujian Medical University, Fuzhou, China Thyroid First Radiology Department, Center for Disease Control Prevention, * These authors have contributed equally to this work Correspondence to: Wang, email: Chen, Keywords : breast cancer, chemotherapy, cognitive disorder, resting-state functional magnetic...
HER-2 positive breast cancer is a subtype of with poor clinical outcome. The aim this study was to identify differentially expressed genes (DEGs) for and elucidate the potential interactions among them.Three gene expression profiles (GSE29431, GSE45827, GSE65194) were derived from Gene Expression Omnibus (GEO) database. GEO2R tool applied obtain DEGs between normal tissues. ontology (GO) annotation analysis Kyoto Encyclopedia Genes Genome (KEGG) pathway enrichment performed by Database...
Abstract Purpose To evaluate the efficacy and safety of pamiparib in patients with locally advanced or metastatic human epidermal growth factor receptor 2-negative (HER2−) breast cancer, deleterious suspected germline BRCA1/2 mutations (g m). Methods In this open-label, phase II, multicenter study China (NCT03575065), triple-negative cancer (TNBC cohort) hormone receptor-positive (HR+)/HER2− (HR+/HER2− ≤ 2 prior lines chemotherapy received 60 mg orally twice daily 28-day, continuous cycles....
Abstract Tumour metabolic reprogramming is pivotal for tumour survival and proliferation. Investigating potential molecular mechanisms within the heterogeneous clinically aggressive triple-negative breast cancer (TNBC) subtype essential to identifying novel therapeutic targets. Accordingly, we investigated role of branched-chain α-keto acid dehydrogenase kinase (BCKDK) in promoting tumorigenesis TNBC. We analysed The Cancer Genome Atlas dataset immunohistochemically stained surgical...