A5046769328- Photoacoustic and Ultrasonic Imaging
- Advanced Fluorescence Microscopy Techniques
- Cell Image Analysis Techniques
- Angiogenesis and VEGF in Cancer
- Radiomics and Machine Learning in Medical Imaging
- Optical Imaging and Spectroscopy Techniques
- Breast Cancer Treatment Studies
- AI in cancer detection
- Immunotherapy and Immune Responses
- Molecular Biology Techniques and Applications
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- Photodynamic Therapy Research Studies
- Advanced X-ray Imaging Techniques
- Cancer Cells and Metastasis
- Immune cells in cancer
- Ovarian cancer diagnosis and treatment
- Gene expression and cancer classification
- Neuroendocrine Tumor Research Advances
- Image Processing Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Research Studies
- Inertial Sensor and Navigation
Fujian Medical University
2016-2025
Union Hospital
2016-2025
Union Hospital
2020
Beijing Institute of Water
2016
The notion of personalized medicine demands proper prognostic biomarkers to guide the optimal therapy for an invasive breast cancer patient. However, various risk prediction models based on conventional clinicopathological factors and emergent molecular assays have been frequently limited by either a low strength prognosis or restricted applicability specific types patients. Therefore, there is critical need develop strong general prognosticator.
Abstract Background Collagen fibers play an important role in tumor initiation, progression, and invasion. Our previous research has already shown that large-scale tumor-associated collagen signatures (TACS) are powerful prognostic biomarkers independent of clinicopathological factors invasive breast cancer. However, they observed on a macroscale more suitable for identifying high-risk patients. It is necessary to investigate the effect corresponding microscopic features TACS so as...
Abstract Biomarkers are indispensable for precision medicine. However, focused single-biomarker development using human tissue has been complicated by sample spatial heterogeneity. To address this challenge, we tested a representation of primary tumor that synergistically integrated multiple in situ biomarkers extracellular matrix from sampling regions into an intratumor graph neural network. Surprisingly, the differential prognostic value computational model over its conventional non-graph...
Stitched fluorescence microscope images inevitably exist in various types of stripes or artifacts caused by uncertain factors such as optical devices specimens, which severely affects the image quality and downstream quantitative analysis. Here, we present a deep learning-based Stripe Self-Correction method, so-called SSCOR. Specifically, propose proximity sampling scheme adversarial reciprocal self-training paradigm that enable SSCOR to utilize stripe-free patches sampled from stitched...
Gastrointestinal stromal tumor (GIST) is currently regarded as a potentially malignant tumor, and early diagnosis the best way to improve its prognosis. Therefore, it will be meaningful develop new method for auxiliary of this disease.Here we try out means detect GIST by combining two-photon imaging with automatic image processing strategy.Experimental results show that microscopy has ability label-freely identify structural characteristics such cells, desmoplastic reaction, which are...
Multiphoton microscopy (MPM) has become a powerful, important tool for tissues imaging at the molecular level. In this paper, technique was extended to histological investigations, differentiating carcinoma in situ (CIS) lesion from normal oesophagus by sections without hematoxylin and eosin (H&E) staining. The results show that histology procedures of dehydration, paraffin embedding, de-paraffinizing highlighted two photon excited fluorescence cytoplasm nucleolus epithelial cell...
Early gastric cancer is associated with a much better prognosis than advanced disease, and strategies to improve strictly dependent on earlier detection accurate diagnosis. Therefore, label-free, non-invasive imaging technique that allows the precise identification of morphologic changes in early would be considerable clinical interest. In this study, multiphoton microscopy (MPM) using two-photon excited fluorescence combined second-harmonic generation was used for cancer. This microscope...
Tumor necrosis (TN) was associated with poor prognosis. However, the traditional classification of TN ignored spatial intratumor heterogeneity, which may be important The purpose this study to propose a new method reveal hidden prognostic value heterogeneity in invasive breast cancer (IBC).Multiphoton microscopy (MPM) used obtain multiphoton images from 471 patients. According relative positions TN, tumor cells, collagen fibers and myoepithelium, four heterogeneities (TN1-4) were defined....
The biological behavior of tumor cells is closely related to invasion, but the relationship between spatial distribution at invasion boundary and prognosis still unknown. In this study, we based Multiphoton Microscopy (MPM) image Tumor-Associated Collagen Signatures (TACS), a biomarker known be associated with Breast Cancer (BC) captured 180μm × regions interest (ROI) on its colocalization hematoxylin eosin (H&E) images. deep neural network was used extract 51 microscopic features from H&E...
Deep learning-based virtual fiber staining provides a promising complement to routine H&E pathology. However, the reliance on predefined style inputs and manual intervention limits clinical applicability of existing methods. To address these challenges, we introduce ViFIT-assisted histopathology, two-stage diagnostic approach that integrates our proposed unsupervised deep transformation model (ViFIT). This enables conversion H&E-stained images with diverse styles into...
Background: To compare clinicopathologic, molecular features, and treatment outcome between fumarate hydratase-deficient renal cell carcinoma (FH-dRCC) type 2 papillary (T2 pRCC). Methods: Data of T2 pRCC patients FH-dRCC with additional next-generation sequencing information were retrospectively analyzed. The cancer-specific survival (CSS) disease-free (DFS) primary endpoint. Results: A combination FH 2-succino-cysteine (2-SC) increased the rate negative predictive value FH-dRCC. Compared...
For complete removal of cancerous tissue in esophageal squamous cell carcinoma (ESCC), intramural metastasis (IM) should be identified preoperatively or intraoperatively. Here, multiphoton microscopy (MPM) was introduced for label-free identification IM the wall, by a combination two-photon excited fluorescence (TPEF), second harmonic generation (SHG) imaging, and spectral analysis. Three-dimensional (3D) imaging region also performed. Quantitative parameters, including 3D fiber orientation,...
Abstract Background The optimal duration of Imatinib adjuvant treatment for patients with high‐risk gastrointestinal stromal tumors (GISTs) is uncertain. Patients and Methods A total 90 GISTs after curative resection were recruited into this non‐randomized case–control study, including 35 having therapy 55 follow‐up alone. recurrence‐free survival (RFS) was compared. Results After a median 44.0 months, significantly reduced recurrence rate observed in the group than control (17.1% vs. 78.2%,...
Blood vessels are the important components of circulatory systems that transport blood throughout human body and maintain homeostasis physiological tissues. Pathologically, often affected by diseases, leading to formation unstable, irregular, hyperpermeable vessels. In tumor microenvironment, abnormal leakage is related histological grade malignant potential tumors may also facilitate metastasis cancer. Visual diagnosis very for us understand occurrence development diseases. Multiphoton...
Abstract Ductal carcinoma in situ with microinvasion (DCISM) is a challenging subtype of breast cancer controversial invasiveness and prognosis. Accurate diagnosis DCISM from ductal (DCIS) crucial for optimal treatment improved clinical outcomes. However, there are often some suspicious small nests DCIS, it difficult to diagnose the presence intact myoepithelium by conventional hematoxylin eosin (H&E) stained images. Although variety biomarkers available immunohistochemical (IHC)...
Summary Esophageal cancer is one of the most common and leading cause death worldwide. Multiphoton microscopy (MPM) has become a novel optical tool choice for imaging tissue architecture cellular morphology based on two‐photon excited fluorescence second harmonic generation. In this study, we used MPM to image microstructure human normal esophagus, carcinoma in situ , early invasive order investigate morphological change structure during phase tumor progression. The diagnostic features such...
Neoadjuvant chemotherapy has been used increasingly in patients with early-stage or locally advanced breast carcinoma, and recommended as a general approach advanced-stage diseases.Assessing therapy response could offer prognostic information to help determine subsequent nursing plan; particularly it is essential identify responders non-responders for the sake of helping develop follow-up treatment strategies.However, at present, diagnostic accuracy preoperative clinical examination are...
In this paper, a nonlinear optical microscopy employing two-photon excited fluorescence and second-harmonic generation was used for the detection of premalignant gastric lesions. It found that gland morphology collagen structure in mucosa will change with progression diseases from normal to intestinal metaplasia, low-grade intraepithelial neoplasia, high-grade able directly distinguish these warning symptoms. Furthermore, two features were quantified images demonstrate changes size content...
Neoadjuvant chemotherapy is increasingly being used in breast carcinoma as it significantly improves the prognosis and consistently leads to an increased rate of preservation. How accurately assess tumor response after treatment a crucial factor for developing reasonable therapeutic strategy. In this study, we were attempt monitor by multimodal multiphoton imaging including two-photon excitation fluorescence second-harmonic generation imaging. We found that can identify different degrees...
The interacting multiple model based on a particle filter fails to meet the requirements of real-time performance when manoeuvring target tracking by radar due deficiencies in its high calculation complexity. An improved landscape adaptive swarm optimization is proposed. This adopts method updating inertia weight, using not only local information and global information, but also preventing algorithm trapping optimum, so can find optimal solution with less iteration. Additionally, an...
Squamous cell carcinoma antigen (SCCA) is an important biomarker in the diagnose of cancer, so developing effective methods for its detection great significance. In present work, a novel sandwich-like electrochemical immunosensing assay (STEM) SCCA was constructed by preparing gold nanoparticle/reduced graphene-oxide (Au NPs/rGO) to immobilize primary antibody (PAb) and UIO-66-NH 2 MOFs structure second (SAb) electroactive toluidine blue (Tb) probe. this designed STEM assay, prepared Au...
Breast cancer can be cured by early diagnosis. Appropriate and effective clinical treatment benefits from accurate pathological However, due to the lack of screening diagnostic imaging methods, stages breast often progress malignant cancer. In this study, multiphoton microscopy (MPM) via two-photon excited fluorescence combined with second-harmonic generation was used for identifying ductal carcinoma. The results showed differences in both cytological features collagen distribution among...