A5016588859- Mycobacterium research and diagnosis
- Fungal Infections and Studies
- Infectious Diseases and Mycology
- Leprosy Research and Treatment
- Autoimmune Bullous Skin Diseases
- Antifungal resistance and susceptibility
- Plant Pathogens and Fungal Diseases
- Tuberculosis Research and Epidemiology
- Nail Diseases and Treatments
- Autoimmune and Inflammatory Disorders
- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Cutaneous lymphoproliferative disorders research
- Psoriasis: Treatment and Pathogenesis
- Eosinophilic Disorders and Syndromes
- Immunodeficiency and Autoimmune Disorders
- Oral Health Pathology and Treatment
- Autoimmune and Inflammatory Disorders Research
- Ocular Surface and Contact Lens
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dermatology and Skin Diseases
- Skin and Cellular Biology Research
- Whipple's Disease and Interleukins
- Dermatological diseases and infestations
- Actinomycetales infections and treatment
Shandong Provincial Institute of Dermatology and Venereology
2016-2025
Shandong First Medical University
2016-2025
Shandong Provincial Hospital
2012-2024
Academy of Medical Sciences
2024
Shandong University
2012-2023
Fujian Women and Children Hospital
2023
Shanghai University of Traditional Chinese Medicine
2015-2019
Anhui Medical University
2012
Tianjin University of Traditional Chinese Medicine
2011
Dapsone is used in the treatment of infections and inflammatory diseases. The dapsone hypersensitivity syndrome, which associated with a reported mortality 9.9%, develops about 0.5 to 3.6% persons treated drug. Currently, no tests are available predict risk syndrome.We performed genomewide association study involving 872 participants who had received as part multidrug therapy for leprosy (39 syndrome 833 controls), using log-additive single-nucleotide polymorphisms (SNPs) imputed HLA...
Dapsone hypersensitivity syndrome (DHS) is the most serious adverse reaction associated with dapsone administration and one of major causes death in patients leprosy, whose standard treatment includes multidrug therapy (MDT) dapsone, rifampicin, clofazimine. Although HLA-B*13:01 polymorphism has been identified as genetic determinant DHS Chinese population, no studies to date have done evaluate whether prospective screening could prevent by identifying who should not receive dapsone.To...
Corynespora cassiicola is a plant pathogen associated with leaf-spotting disease. The fungus has been found on diverse substrates: leaves, stems and roots of plants; nematode cysts human skin. It rarely causes infections. Here we report one case subcutaneous phaeohyphomycosis caused by C. prominent tissue necrosis in woman. All her clinical features pointed towards genetic linkage. Hence, whole-exome sequencing Sanger were performed this patient. One mutation CARD9 was detected.
Recently, a number of non-HLA (human leucocyte antigen) psoriasis genetic susceptibility loci have been identified through genome-wide association studies, but data on their with psoriatic arthritis (PsA) are lacking.To investigate recently in cohort Chinese patients PsA, vulgaris (PsV) and healthy controls.Twenty single-nucleotide polymorphisms (SNPs) from 20 were selected for genotyping 379 595 PsV 1181 controls using the MassARRAY platform (Sequenom, San Diego, CA, U.S.A.). Data handling,...
Although genome-wide association studies have greatly advanced our understanding of the contribution common noncoding variants to leprosy susceptibility, protein-coding not been systematically investigated. We carried out a three-stage study in Han Chinese, whom were 7,048 patients and 14,398 healthy control subjects. Seven coding exome-wide significance discovered, including two rare variants: rs145562243 NCKIPSD (P = 1.71 × 10-9, odds ratio [OR] 4.35) rs149308743 CARD9 2.09 10-8, OR 4.75);...
The biological connections between psoriasis and diabetes have been suggested by epidemiological, immunological genetic studies. To identify additional shared susceptibility loci investigate pathogenesis these two diseases, we genotyped 89 reported in 4456 cases 6027 controls of Chinese population using the MassARRAY system from Sequenom. We discovered three significant associations at rs6679677 on 1p13.2 (P=6.15×10-5 , OR=5.07), rs16861329 3q27.3 (P=2.02×10-4 OR=0.87) rs849135 7p15.1...
The discovery of pathogenic variants provided biological insight into the role host genetic factors in generalized pustular psoriasis (GPP). However, not all those affected by GPP carry reported genes. To comprehensively explore molecular pathogenesis GPP, whole-exome sequencing was performed, and two loci were identified with exome-wide significance through single variant association analysis: rs148755083 IL36RN gene (Pcombined = 1.19 × 10-18, OR 8.26) HLA-C∗06:02 within major...
A population-based study of Chlamydia trachomatis (CT) infections is essential in designing a specific control program; however, no large investigation CT among the general population mainland China has been conducted since 2000. We aimed to determine prevalence, risk factors, and associated medical costs residents, 18-49 years age, Shandong, China.From May August 2016, multistage probability sampling survey involving 8074 individuals was distributed. Data were collected via face-to-face...
The current gold standard for diagnosing onychomycosis is direct microscopic examination and culturing. Fungal culture a time-consuming procedure, while microscopy of potassium hydroxide (KOH) mounts suffers from low sensitivity. More rapid sensitive methods the diagnosis are in high demand.To establish an effective method by assessing efficacies fungal fluorescent staining internal transcribed spacer (ITS) ribosomal DNA (rDNA) polymerase chain reaction (PCR)-based sequencing.A total 204...
Pathogen-induced epigenetic modifications can reshape anti-infection immune processes and control the magnitude of host responses. DNA methylation profiling has identified crucial aberrant changes associated with diseases, thus providing biological insights into roles factors in mycobacterial infection. In this study, we performed a genome-wide analysis skin biopsies from patients leprosy healthy controls. T helper 17 differentiation pathway was found to be significantly through functional...
Previous genome-wide association studies (GWASs) identified multiple susceptibility loci that have highlighted the important role of TLR (Toll-like receptor) and CARD (caspase recruitment domain) genes in leprosy. A large three-stage candidate gene-based study 30 47 was performed leprosy samples Chinese Han. Of 4363 SNPs investigated, eight showed suggestive (P < 0.01) our previously published GWAS datasets (Stage 1). SNPs, rs2735591 rs4889841 significant 0.001) an independent series 1504...
Abstract Genetic polymorphism within the 9q32 locus is linked with increased risk of several diseases, including Crohn’s disease (CD), primary biliary cholangitis (PBC) and leprosy. The most likely disease-causing gene TNFSF15 , which encodes pro-inflammatory cytokine TNF super-family member 15, but it was unknown whether these disparate diseases were associated same genetic variance in 9q32, how this might contribute to pathology. Using data from published studies on CD, PBC leprosy we...
Seven new risk coding variants have been identified through an exome‐wide association study (EWAS), which studied the contributions of protein‐coding to leprosy susceptibility. But some potential susceptibility loci were not in previous EWAS because project consideration. Seventeen unstudied validated 3169 cases and 9814 controls this study. Four disease‐associated exonic identified: rs671 ALDH2 ( P = 2.0 × 10 −20 , odds ratio [OR] 1.35), rs13259978 SLC7A2 1.74 −8 OR 1.28), rs925368 GIT2...
Abstract Background Pemphigus is an autoimmune blistering disease with pemphigus vulgaris ( PV ) and foliaceus PF as the two major histological subtypes. Associations HLA molecules have been suggested, but specific risk variants well non‐ remain to be discovered. Methods We performed a two‐stage genome‐wide association study in Chinese Han population through discovery analysis follow‐up validation total number of 210 , 159 2493 healthy controls. imputation high coverage next generation...
Herpes simplex virus type-2 (HSV-2) infection is the main cause of genital ulcer disease and increases risk HIV acquisition. Little information available regards epidemiological characteristics HSV-2 among general population in China. The aim this study was to explore seroprevalence associated factors provide for design control strategy Shandong, In cross-sectional study, a total 8074 persons, 18–49 years age, were selected using multi-stage probability sampling represent Shandong 2016....
Background Artificial intelligence breast ultrasound diagnostic system (AIBUS) has been introduced as an alternative approach for handheld (HHUS), while their results in BI-RADS categorization not compared. Methods This pilot study was based on a screening program conducted from May 2020 to October southeast China. All the participants who received both HHUS and AIBUS were included ( N = 344). The videos after scanning independently watched by senior radiologist junior radiologist. Agreement...
Dapsone hypersensitivity syndrome is a rare yet severe adverse drug reaction caused by dapsone, principal in multidrug therapy for leprosy. HLA-B*13:01 has been identified as strong risk factor of dapsone syndrome; however, its low positive predictive value indicated that additional genetic variants may be involved the disease development. To discover contributing within HLA loci addition to HLA-B*13:01, we performed high-coverage next-generation sequencing (NGS)-based typing analysis 103...