A5103004997- Spinal Cord Injury Research
- MicroRNA in disease regulation
- Nerve injury and regeneration
- Mesenchymal stem cell research
- Neurogenetic and Muscular Disorders Research
- Circular RNAs in diseases
- Electrospun Nanofibers in Biomedical Applications
- Neurogenesis and neuroplasticity mechanisms
- Extracellular vesicles in disease
- Bacillus and Francisella bacterial research
- Neuroinflammation and Neurodegeneration Mechanisms
- Obstructive Sleep Apnea Research
- Axon Guidance and Neuronal Signaling
- Restless Legs Syndrome Research
- Multiple Sclerosis Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Wound Healing and Treatments
- Rabies epidemiology and control
- Anesthesia and Neurotoxicity Research
- Osteoarthritis Treatment and Mechanisms
- Tissue Engineering and Regenerative Medicine
- Liver physiology and pathology
- Neurological Disease Mechanisms and Treatments
- Genomics, phytochemicals, and oxidative stress
- Healthcare Systems and Reforms
Key Laboratory of Guangdong Province
2021-2024
Third Affiliated Hospital of Sun Yat-sen University
2019-2024
Sun Yat-sen University
2019-2024
National Medical Products Administration
2022-2023
Guangzhou University of Chinese Medicine
2023
This study aimed to investigate the effect of bone marrow mesenchymal stem cell (BMSC)-derived exosome injection on cartilage damage and pain relief in both vitro vivo models osteoarthritis (OA).The BMSCs were extracted from rat femur tibia. Chondrocytes treated with IL-1β establish model OA. Chondrocyte proliferation migration assessed by CCK-8 transwell assay, respectively. A OA was established sodium iodoacetate. At 6 weeks after established, knee joint specimens dorsal root ganglion...
Abstract Background Exosomes derived from the bone marrow mesenchymal stem cell (MSC) have shown great potential in spinal cord injury (SCI) treatment. This research was designed to investigate therapeutic effects of miR-26a-modified MSC-derived exosomes (Exos-26a) following SCI. Methods Bioinformatics and data mining were performed explore role miR-26a isolated MSC culture medium by ultracentrifugation. A series experiments, including assessment Basso, Beattie Bresnahan scale, histological...
Spinal cord injury (SCI) is a devastating neurological disease that often results in tremendous loss of motor function. Increasing evidence demonstrates diabetes worsens outcomes for patients with SCI due to the higher levels neuronal oxidative stress. Mammalian sterile 20-like kinase (MST1) key mediator stress central nervous system; however, mechanism its action still not clear. Here, we investigated role MST1 activation induced both and diabetes. Diabetes was established mice by diet...
Conductive scaffolds have been shown to exert a therapeutic effect on patients suffering from peripheral nerve injuries (PNIs). However, conventional conductive conduits are made of rigid structures and limited applications for impaired diabetic due their mechanical mismatch with neural tissues poor plasticity. We propose the development biocompatible electroconductive hydrogels (ECHs) that identical surgical dressing in this study. Based excellent adhesive self-healing properties, thin...
Spinal cord injury (SCI) results in massive neuronal death, axonal disruption, and cascading inflammatory response, which causes further damage to impaired neurons. The survived neurons with damaged function fail form effective circuits. It is mainly caused by the neuroinflammatory microenvironment at sites regenerated axons without guidance. To address this challenge, a ferrofluid hydrogel (FFH) was prepared Ferric tetrasulfide (Fe3S4), carboxymethyl chitosan, gold. Its internal structural...
Emerging evidence indicates that microRNAs play a pivotal role in neural remodeling after spinal cord injury (SCI). This study aimed to investigate the mechanisms of miR-135a-5p regulating functional recovery SCI by impacting its target genes and downstream signaling. The gene transfection assay luciferase reporter confirmed relationship between (specificity protein 1 [SP1] Rho-associated kinase [ROCK]1/2). By establishing H2O2-induced model, was found inhibit apoptosis PC12 cells...
<title>Abstract</title> Spinal cord injury (SCI) leads to severe mitochondrial dysfunction and ROS cascade, with microglia playing a dual role in both exacerbating damage providing neuroprotection. Recent evidence has highlighted the importance of P2Y12R microglial-neuron interactions, particularly modulating quality control mitigating oxidative stress. Here, we develop dual-targeting nanoparticle system (P2Y-Nano) enhance expression activated promote neuronal mitophagy, aiming reduce...
Abstract Neuromyelitis optica spectrum disorder (NMOSD) is a severe inflammatory autoimmune disease of the central nervous system that manifested as secondary myelin loss. Oligodendrocyte progenitor cells (OPCs) are principal source myelinating oligodendrocytes (OLs) and abundant in demyelinated regions NMOSD patients, thus possibly representing cellular target for pharmacological intervention. To explore therapeutic compounds enhance myelination due to endogenous OPCs, we screened candidate...
Abstract Background The brain vascular basement membrane (brain-VBM) is an important component of the extracellular matrix, and three-dimensional structure cerebrovascular network nested with many cell-adhesive proteins may provide guidance for tissue regeneration. However, potential ability brain-VBM to promote neural regeneration has not been examined due technical difficulty isolating intact brain-VBM. Methods present study developed a simple, effective method isolate structurally...
This study assesses the diagnostic delay, treatment duration and outcomes of tuberculosis (TB) patients since implementation integrated model TB control in a county eastern China. It further identifies factors associated with delay model.We collected data through Chinese Tuberculosis Information Management System (TBIMS) for Cangnan County Zhejiang Province. Chi-square Mann-Whitney tests were adopted to identify within model. Multiple regression analysis was subsequently performed confirm...
Abstract In the realm of neural regeneration post‐spinal cord injury, hydrogel scaffolds carrying induced stem cells (iNSCs) have demonstrated significant potential. However, challenges such as graft rejection and dysfunction caused by mitochondrial damage persist after transplantation, presenting formidable barriers. Tacrolimus, known for its dual role an immunosuppressant promoter regeneration, holds potential enhancing iNSC transplantation. systemic administration tacrolimus often comes...