A5046806414- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Neuroinflammation and Neurodegeneration Mechanisms
- CNS Lymphoma Diagnosis and Treatment
- Autoimmune Neurological Disorders and Treatments
- Immunotherapy and Immune Responses
- Inflammation biomarkers and pathways
- Connective tissue disorders research
- Fungal Infections and Studies
- Retinal Diseases and Treatments
- Galectins and Cancer Biology
- Neurogenesis and neuroplasticity mechanisms
- Mycobacterium research and diagnosis
- Complement system in diseases
- Acute Ischemic Stroke Management
- Barrier Structure and Function Studies
- Gut microbiota and health
- Dermatological and Skeletal Disorders
- Tryptophan and brain disorders
- Protein Tyrosine Phosphatases
- Neonatal Respiratory Health Research
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Sphingolipid Metabolism and Signaling
Third Affiliated Hospital of Sun Yat-sen University
2014-2024
Sun Yat-sen University
2014-2024
China Three Gorges University
2023
<b><i>Background:</i></b> Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a novel meningoencephalomyelitis. However, the pathogenesis of this disease unclear. We therefore examined brain biopsy from patient with autoimmune GFAP by immunohistopathology. <b><i>Methods:</i></b> sections using hematoxylin and eosin (HE) Luxol fast blue (LFB) staining, immunostaining antibodies for CD4, CD8, CD3, CD20, CD68, CD138, Neu-N, GFAP,...
Triggering receptor expressed on myeloid cell 2 (TREM2) signaling often drives opposing effects in traumatic versus demyelinating CNS disorders. Here, we identify two distinct phenotypes of microglia and infiltrating populations dependent TREM2 expression levels at the acute stage elucidate how they mediate spinal cord injury (SCI) multiple sclerosis animal models (experimental autoimmune encephalomyelitis [EAE]). High sustain phagocytic macrophages after SCI. In contrast, moderate...
Background: Myelin oligodendrocyte glycoprotein (MOG) antibody associated encephalomyelitis is increasingly being considered a distinct disease entity, with seizures and encephalopathy commonly reported. We investigated the clinical features of MOG-IgG positive patients presenting and/or in single cohort. Methods: Consecutive suspected idiopathic inflammatory demyelinating diseases were recruited from tertiary University hospital Guangdong province, China. Subjects seropositivity analyzed...
Abstract Neuromyelitis optica spectrum disorder (NMOSD) is a severe inflammatory autoimmune disease of the central nervous system that manifested as secondary myelin loss. Oligodendrocyte progenitor cells (OPCs) are principal source myelinating oligodendrocytes (OLs) and abundant in demyelinated regions NMOSD patients, thus possibly representing cellular target for pharmacological intervention. To explore therapeutic compounds enhance myelination due to endogenous OPCs, we screened candidate...
From the perspective of role T follicular helper (Tfh) cells in destruction tolerance disease progression, more attention has been paid to their autoimmunity. To address Tfh neuromyelitis optica spectrum disorder (NMOSD) recurrence, serum C-X-C motif ligand 13 (CXCL13) levels reflect effects on B-cell-mediated humoral immunity. We evaluated immunobiology CXCR5+CD4+ 46 patients with NMOSD, including 37 NMOSD an annual recurrence rate (ARR) of<1 and 9 ARR ≥1. Herein, we reported several key...
Background and purpose: The mechanism underlying the pathology of neuromyelitis optica spectrum disorders (NMOSD) remains unclear even though antibodies to water channel protein aquaporin-4 (AQP4) on astrocytes play important roles. Our previous study showed that dysbiosis occurred in faecal microbiota NMOSD patients. In this study, we further investigated whether intestinal barrier mucosal flora balance are also interrupted Methods: Sigmoid biopsies were collected by endoscopy from six...
We investigated the serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels in a cohort of Chinese patients with neuromyelitis optica spectrum disorders (NMOSD) multiple sclerosis (MS) relation to clinical disease course treatment. sNfL sGFAP were determined by ultrasensitive single molecule array (Simoa) assay NMOSD (n = 102) MS 98) healthy controls (HCs; n 84). Notably, 13 27 enrolled 1-year follow-up cohort. Levels compared data such as course, duration,...
The aim was to characterize the optical coherence tomography (OCT) angiography measures in patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) evaluate their disease discrimination capacity.Patients MS (n = 83) AQP4-IgG-seropositive NMOSD 91) or without a history of optic neuritis, together healthy controls 34), were imaged. main outcome peripapillary retinal nerve fiber layer (pRNFL) thickness, macular ganglion cell-inner plexiform (GC-IPL) vessel...
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease. Although genetic factors are involved in its pathogenesis, limited evidence available this area. The aim of the present study was to identify major contributing NMOSD Chinese patients with aquaporin 4 (AQP4)-IgG seropositivity.Whole-exome sequencing (WES) performed on 228 seropositive for AQP4-IgG and 1400 healthy controls Guangzhou, South China. Human leukocyte antigen (HLA) also utilized. Genotype model haplotype,...
Background and purpose This study aimed to evaluate the relationship between serum complement anti‐ N ‐methyl‐ d ‐aspartate receptor ( NMDAR ) encephalitis. Methods Serum (C3, C4 CH 50), immunoglobulins (IgG, IgM IgA) C‐reactive protein CRP were evaluated in 40 patients with encephalitis controls. Follow‐up evaluations of 11 conducted 6 months after admission. Modified Rankin Scale mRS scores clinical cerebrospinal fluid parameters Results levels significantly higher than controls P =...
Objective To explore the outcomes of NMOSD attacks and investigate serum biomarkers for prognosis severity. Method Patients with were prospectively observationally enrolled from January 2019 to December 2020 at four hospitals in Guangzhou, southern China. Data collected attack, discharge 1/3/6 months after acute treatment. Serum cytokine/chemokine neurofilament light chain (NfL) levels examined onset stage. Results One hundred patients included. The treatment comprised intravenous...
Patients presenting with clinical characteristics that are strongly suggestive of neuromyelitis optica spectrum disorders (NMOSD) have a high risk developing definite NMOSD in the future. Little is known about course, treatment, and prognosis these patients likely at disease onset.This study prospectively recruited visited 24 limited form (LF-NMOSD) onset from November 2012 to June 2021. Their demographics, longitudinal aquaporin-4 immunoglobulin G (AQP4-IgG) serology, MRI, therapeutic...