Summary Background In addition to their original applications for lowering cholesterol, statins display multiple neuroprotective effects. Inflammatory reactions and the PI 3K/ AKT /caspase 3 pathway are strongly implicated in dopaminergic neuronal death P arkinson's disease ( PD ). This study aims investigate how simvastatin affects 6‐hydroxydopamine‐lesioned PC 12 via regulating modulating inflammatory mediators. Methods 6‐hydroxydopamine‐treated cells were used neuroprotection of...

Abstract Background Accumulating evidence indicates that CD36 initiates metastasis and correlates with an unfavorable prognosis in cancers. However, there are few reports regarding the roles of initiation cervical cancer. Methods Using immunohistochemistry, we analyzed 133 cancer samples for protein expression levels, then investigated correlation between changes its clinicopathologic parameters. The effect on epithelial–mesenchymal transition (EMT) cells was evaluated by Western...

Cadmium (Cd) is a highly toxic element for plant growth. In plants, hydrogen sulfide (H2S) and methylglyoxal (MG) have emerged as vital signaling molecules that regulate growth processes under Cd stress. However, the effects of sodium hydrosulfide (NaHS, donor H2S) MG on uptake, physiological responses, gene expression patterns Salix to toxicity been poorly understood. Here, matsudana Koidz. seedlings were planted in plastic pot with applications (108 mg kg- 1) NaHS (50 (150 stress.Cd...

Atherosclerosis, a multifactorial chronic disease, is the main cause of death and impairment in world. Endothelial cells (ECs) apoptosis plays crucial role onset development atherosclerosis, whereas underlying molecular mechanisms are unclear. MicroRNA-142-3p (miR-142-3p) well-defined tumor suppressor several types cancer, while miR-142-3p ECs atherosclerosis has yet to be elucidated. Therefore, present study aimed investigate during mechanism.Human aortic endothelial (HAECs) were treated...

Exercise therapy including endurance training and resistance is a promising non-pharmacological in patients with multiple sclerosis (MS). Recent studies have revealed that exercise exerts beneficial impacts on gut microbiota. However, the role of microbiota immune benefits strength (SE; one training) central nervous system (CNS) autoimmunity barely known. Here, we observed 60-min SE ameliorated disease severity neuropathology experimental autoimmune encephalomyelitis (EAE), an animal model...

Increased expression of some matrix metalloproteinases (MMPs) is closely associated with epilepsy.However, factors that promote their have not been clarified.Long noncoding RNAs (lncRNAs) play crucial roles in the development human diseases, including various cancers, but its potential function temporal lobe epilepsy (TLE) has remained unexplored.In this study, we showed hippocampal and serum ILF3-AS1 levels are higher TLE patients than matched controls.Interleukin (IL)-1β tumor necrosis...

Objective: Parkinson's disease (PD) is associated with dysregulated neural cell death, such as pyroptosis, but its regulatory mechanisms are poorly understood. This study investigated roles of nuclear factor E2-related 2 (Nrf2) in regulating pyroptosis and PD development. Methods: Cellular rat models established by 6-OHDA exposure were subjected to Nrf2 overexpression. Neurobehavioral functions assessed the traction test, Morris Water Maze, open field test. Cell proliferation was analyzed...

<b><i>Background:</i></b> Elevation of serum uric acid (UA) is correlated with a decreased risk Parkinson’s disease (PD); however, the association and clinical relevance UA levels in patients PD vascular parkinsonism (VP) are unknown. <b><i>Objective:</i></b> We performed cross-sectional study 160 Chinese VP to determine whether could predict outcomes. <b><i>Methods:</i></b> Serum were divided into quartiles between...

To investigate the expression of long noncoding RNA (LncRNA) MIRG and its potential functions in regulating osteoclastogenesis bone resorption function through modulating miR-1897 marrow macrophages (BMMs).qRT-PCR was performed to detect expressions co-expression mRNA NFATc1 at different stages during osteoclastogenesis. The CCK-8 assay evaluate cell proliferation differentiation. correlation between detected by statistical analysis. Bioinformatics luciferase were explore interaction binding...

The study investigated the effect of soluble dietary fiber supplementation on gut microbiota, mucosal barrier function, inflammatory markers, and survival in a murine model sepsis established by cecal ligation puncture (CLP). expression muc2 was down-regulated septic mice. However, significantly increased mice that received fiber. Survival also improved treated with benefit associated decreased serum concentrations pro-inflammatory cytokines reduced neutrophil infiltration gut. Furthermore,...

Background: Acute respiratory distress syndrome (ARDS) is a severe form of organ dysfunction and common postoperative complication. This study aims to develop predictive model for ARDS in patients with gastrointestinal perforation facilitate early detection effective prevention. Methods: In this single-center retrospective study, clinical data were collected from admitted the ICU Hebei Provincial People's Hospital October 2017 May 2024. Univariate analysis multifactorial logistic regression...

This study aimed to establish normal reference values for multimodal diaphragmatic ultrasound indices in healthy adult volunteers and evaluate intra-and inter-observer consistency between physicians critical care physicians. An physician (US physician) used techniques such as B-mode, M-mode, Tissue Doppler Imaging (TDI), shear wave elastography (SWE) measure parameters 46 adults during quiet deep breathing. A (CC trained repeated these measurements. Consistency was analyzed intra-researcher...

This study aimed to characterize the prognostic and therapeutic implications of disulfidptosis-related genes (DRGs) in head neck squamous cell carcinoma (HNSCC). Using multi-omics data from Cancer Genome Atlas (TCGA) (n = 500) Gene Expression Omnibus (GEO) cohorts 270), we performed unsupervised consensus clustering, functional enrichment, immune deconvolution, survival analyses identify DRG-driven molecular subtypes. A disulfidptosis score (DRGscore) was developed via principal component...

ABSTRACT Combined cardiopulmonary ultrasound (CCPUS) can be applied to bedside differential diagnosis of acute dyspnea. Pulmonary interstitial fibrosis is usually a chronic lung disease. However, some special diseases cause pulmonary with rapid progression. This study included patient unexplained We excluded cardiogenic edema (CPE) by CCPUS and refused hemodialysis. The characteristics the were similar fibrosis. Finally, was diagnosed antiglomerular basement membrane (anti‐GBM) disease...

Myeloid-derived suppressor cells (MDSCs), comprising polymorphonuclear (PMN-MDSCs) and monocytic subsets (M-MDSCs), are immunosuppressive immature myeloid implicated in disease progression prognosis across multiple pathologies. To investigate the clinical significance of early MDSCs subset expansion critical illness identify novel prognostic biomarkers for risk stratification. This prospective study enrolled 85 critically ill adults (APACHE II ≥15), stratified into survivors (n=47)...

Background The elevation of plasma homocysteine (Hcy) and C-reactive protein (CRP) has been correlated to an increased risk Parkinson's disease (PD) or vascular diseases. association clinical relevance a combined assessment Hcy CRP levels in patients with PD parkinsonism (VP) are unknown. Methodology/Principal Findings We performed cross-sectional study 88 Chinese VP using interview the measurement determine if may predict outcomes motor status, non-motor symptoms (NMS), severity, cognitive...