A5100384089- Esophageal Cancer Research and Treatment
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Head and Neck Cancer Studies
- Hip and Femur Fractures
- Esophageal and GI Pathology
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Ferroptosis and cancer prognosis
- FOXO transcription factor regulation
- Diet, Metabolism, and Disease
- Lung Cancer Treatments and Mutations
- Plant Micronutrient Interactions and Effects
- Reconstructive Surgery and Microvascular Techniques
- Sarcoma Diagnosis and Treatment
- Potato Plant Research
- Helicobacter pylori-related gastroenterology studies
- Heavy metals in environment
- Microbial Metabolic Engineering and Bioproduction
- Oral and Maxillofacial Pathology
- Orthodontics and Dentofacial Orthopedics
Northeast Forestry University
2011-2025
Xi'an Jiaotong University
2017-2025
Eighth Affiliated Hospital of Sun Yat-sen University
2017-2025
Xi'an Honghui Hospital
2017-2025
Sun Yat-sen University
2017-2025
Mongolian University of Science and Technology
2025
Inner Mongolia University
2025
Southern Medical University
2012-2024
Tongji University
2023-2024
Shandong First Medical University
2013-2024
Hidden blood loss is a major concern for patients undergoing hip surgery intertrochanteric fracture. The objective of this study was to investigate whether tranexamic acid (TXA) could reduce postoperative hidden in A total 77 with fracture were enrolled randomized controlled study. Patients received either 200 mL (1 g) TXA (n = 37) or normal-saline (NS) 40) i.v. before using proximal femoral nail anti-rotation (PFNA). Hemoglobin and hematocrit levels measured preoperatively postoperatively...
Methanol, synthesized from CO2, is a potentially sustainable one-carbon (C1) resource for biomanufacturing. The use of methanol as feedstock to produce single cell protein (SCP) has been investigated decades an alternative alleviate the high global demand animal-derived proteins. methylotrophic yeast Pichia pastoris ideal host methanol-based SCP synthesis due its natural assimilation ability. However, improving utilization, tolerance higher temperature, and content P. are also current...
Our aim was to identify frequent genomic aberrations in both esophageal squamous cell carcinoma (ESCC) and dysplasia discover important copy number-driving genes microRNAs (miRNA) ESCC.We conducted array-based comparative hybridization (array CGH) on 59 ESCC resection samples 16 biopsy samples. Expression of at 11q13.3 analyzed by real-time PCR (RT-PCR) immunohistochemistry (IHC). Integrated analysis or miRNAs with number-expression correlations.Array CGH identified 11 amplifications eight...
Abstract Background Accumulating evidence indicates that CD36 initiates metastasis and correlates with an unfavorable prognosis in cancers. However, there are few reports regarding the roles of initiation cervical cancer. Methods Using immunohistochemistry, we analyzed 133 cancer samples for protein expression levels, then investigated correlation between changes its clinicopathologic parameters. The effect on epithelial–mesenchymal transition (EMT) cells was evaluated by Western...
Rectification of HERG is due to a rapid inactivation process that has been labeled C-type and believed be closure the external mouth pore. We examined effects mutation extracellular residues remove on binding intracellularly acting methanesulfonanilide drug E-4031. Removal through reduced affinity by more than an order magnitude. Elevation [K+]o in wild-type channel reduces for also interferes with pore associated 'foot door' mechanism. possibility elevation inhibition comparing block...
The molecular basis of K+ currents that generate repolarization in the heart is uncertain. In part, this reflects similar functional properties different channel clones display when heterologously expressed, addition to diversity voltage-gated family. To determine identity, regional distribution, and cellular distribution voltage-sensitive mRNA subunits expressed ferret heart, we used fluorescent labeled oligonucleotide probes perform situ hybridization studies on enzymatically isolated...
The aim of this study was to evaluate the prevalence PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) expression, and explore prognostic significance expression alone in combination with Ki67 p53 non-small-cell lung cancer (NSCLC).We detected 30 samples normal tissue, 32 lymph node metastases 279 primary cancers by immunohistochemistry, analysed correlation tumour tissues. results showed that higher (75%) than tumours (44.8%) tissues (0%). associated histological type,...
Single-cell protein (SCP) production in the methylotrophic yeast Pichia pastoris has potential to achieve a sustainable supply. However, improving methanol fermentation efficiency and reducing carbon loss been long-standing challenge with far-reaching scientific practical implications. Here, comparative transcriptomics revealed that PAS_0305, gene directly associated cell wall thickness under stress, can be used as target for unlocking sensors. Intracellular trehalose accumulation confirmed...
Background Recent research showed that probiotics treatment may reduce insulin resistance, regulate lipid metabolism, raise liver enzyme levels, and ameliorate inflammation in individuals with metabolic associated fatty disease (MAFLD). However, the possible effects of probiotic use on progression hepatic steatosis (HS) have not been identified. The purpose this study was to investigate a large population database. Methods cross-sectional conducted among adults complete data yogurt...
Cervical cytology is a critical screening strategy for early detection of pre-cancerous and cancerous cervical lesions. The challenge lies in accurately classifying various cell types. Existing automated methods are primarily trained on databases covering narrow range coarse-grained types, which fail to provide comprehensive detailed performance analysis that represents real-world cytopathology conditions. To overcome these limitations, we introduce HiCervix, the most extensive, multi-center...
The rapid delayed rectifier, I Kr is believed to have h‐ erg ( uman ther‐à‐go‐go elated ene) as its molecular basis. A recent study has shown that rectification of involves a inactivation process closure the external mouth pore or C‐type inactivation. We measured instantaneous current voltage relationship for channels using saponin permeabilized variation cut‐open oocyte clamp technique. In contrast in other voltage‐gated K + channels, rate was strongly dependent at depolarized potentials....
Abstract Background Tongue squamous cell carcinoma (TSCC) is one of the most common oral tumors. Recently, long intergenic noncoding RNA 00958 (LINC00958) has been identified as an oncogene in human cancers. Nevertheless, role LINC00958 and its downstream mechanisms TSCC still unknown. Methods The effect on cells proliferation growth were assessed by CCK-8, colony formation, 5-Ethynyl-2′-deoxyuridline (EdU) assay flow cytometry assays vitro tumor xenograft model vivo. Bioinformatics analysis...
Abstract Chemotherapy resistance in colorectal cancer (CRC) remains a major obstacle clinical oncology. Analysis of specimens from chemotherapy-resistant patients revealed elevated CXCL7 expression tumor-associated macrophages (TAMs). Through integrated vitro and vivo studies, we demonstrated that chemotherapy induces tumor cell-macrophage crosstalk, leading to upregulation TAMs. Using co-culture system, observed CXCL7+ confer chemoresistance CRC cells. Mechanistic investigations activates...