A5101459564- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Zebrafish Biomedical Research Applications
- Histone Deacetylase Inhibitors Research
- Biomedical Ethics and Regulation
- Cell death mechanisms and regulation
- interferon and immune responses
- Cancer therapeutics and mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Fibroblast Growth Factor Research
- Pluripotent Stem Cells Research
- Immune cells in cancer
- Cancer-related gene regulation
- Phagocytosis and Immune Regulation
- Biological Activity of Diterpenoids and Biflavonoids
- Genomics, phytochemicals, and oxidative stress
- RNA Research and Splicing
- Traditional and Medicinal Uses of Annonaceae
- Acute Myocardial Infarction Research
- Advanced biosensing and bioanalysis techniques
- Genomics and Chromatin Dynamics
- Cardiac Fibrosis and Remodeling
Renji Hospital
2011-2025
Shanghai Jiao Tong University
2013-2025
Zhujiang Hospital
2024
Zhongshan Hospital of Xiamen University
2022
The role of SRY-related high-mobility-group box (SOX) 12 in leukaemia progression and haematopoiesis remains elusive. This study aimed to examine the expression function SOX12 acute myeloid (AML) using human samples cell line THP1. Mononuclear cells were isolated from bone marrow AML patients healthy donors. haematopoietic was evaluated by reverse transcription polymerase chain reaction (RT-PCR). short hairpin RNAs (shRNAs) transduced into THP1 cells, gene knockdown confirmed quantitative...
Abstract Chemotherapy resistance in colorectal cancer (CRC) remains a major obstacle clinical oncology. Analysis of specimens from chemotherapy-resistant patients revealed elevated CXCL7 expression tumor-associated macrophages (TAMs). Through integrated vitro and vivo studies, we demonstrated that chemotherapy induces tumor cell-macrophage crosstalk, leading to upregulation TAMs. Using co-culture system, observed CXCL7+ confer chemoresistance CRC cells. Mechanistic investigations activates...
Acute myeloid leukemia (AML) 1-Evi-1 is a chimeric gene generated by the t (3; 21) (q26; q22) translocation, which leads into malignant transformation of hematopoietic stem cells unclear mechanisms. This in vivo study aimed to establish stable line zebrafish expressing human RUNX1-Evi-1 fusion under control heat stress-inducible bidirectional promoter, and investigate its roles hematopoiesis hematologic malignancies.We introduced embryonic through heat-shock promoter Tg(RE:HSE:EGFP)...
Acute myeloid leukemia (AML) patients with FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) have a high relapse rate and poor prognosis. This study aims to explore the underlying mechanism of combining Gilteritinib ATO at low concentration in treatment FLT3-ITD positive leukemias.We used both vitro vivo studies investigate effects combination on leukemias, together molecular mechanisms these processes.Combination showed synergistic inhibiting proliferation, increasing...
FMS-like tyrosine kinase 3 (FLT3) mutant acute myeloid leukemia (AML) occurs in approximately 30% of all AML patients and still has a poor prognosis. This study is directed to investigate gilteritinib combination with homoharringtonine (HHT) on FLT3-ITD-mutant cell lines. In our study, we found that proliferation was dramatically suppressed by the HHT. therapy decreased mitochondrial membrane potential, finally inducing apoptosis. We demonstrated downregulated expression FLT3 downstream...
Abstract The function and phenotype of tumor-associated macrophages (TAMs) influence the efficacy radiotherapy. However, effect different subsets TAMs on radioresistance in nasopharyngeal carcinoma (NPC) still needs to be further explored. This study utilized single-cell RNA sequencing (scRNA-seq) analyze 120,579 cells obtained from 15 NPC samples. Cell annotation, cell‒cell communication analysis, functional annotation were used investigate impact effectiveness radiotherapy patients....
Background: The role of soluble interleukin-1 receptor type 2 (sIL-1R2) in acute myocardial infarction (AMI) remains undocumented. In the present study, we aimed to evaluate possible associations sIL-1R2 with left ventricular (LV) function, remodeling and future clinical events setting AMI. Methods: Circulating levels were quantified after percutaneous coronary intervention (PCI) on day 1 hospital admission for 204 AMI patients, upon enrollment healthy controls. Echocardiography was...
Objective To investigate the effect and mechanism of different G-CSF-priming protocols on leukemia cell lines (HL-60 U937) in vitro provide clinical guidance to treatment acute leukemia.Methods The HL-60 U937 were used as model detect effects three drugs alone combined two (HA) or (HAG) respectively.Cell viability growth inhibition performed by count kit-8 (CCK-8) assay.Apoptotic marker AnnexinV/PI,cell membrane surface antigen CD11b,cell cycle,mitochondrial potential (JC-1) Caspase-3...
Glaucatotones A−I, nine new guaiacane-type sesquiterpenoids, along with the reported compounds, namely (1β,5β)-1-hydroxyguaia-4(15),11(13)-dieno-12,5-lactone (10) and pseudoguaianelactone C (11), were isolated from roots of Lindera glauca. The structures absolute configurations these compounds elucidated by extensive spectroscopic analyses, single-crystal X-ray diffraction, comparison experimental calculated electronic circular dichroism (ECD) data. Structurally, glaucatotone A (1) is...