A5023519725- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Constructed Wetlands for Wastewater Treatment
- Pharmaceutical and Antibiotic Environmental Impacts
- Bioinformatics and Genomic Networks
- Lung Cancer Treatments and Mutations
- Breast Lesions and Carcinomas
- Renal and related cancers
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Genomics and Chromatin Dynamics
- Lung Cancer Research Studies
- Breast Cancer Treatment Studies
- Gene expression and cancer classification
- Mosquito-borne diseases and control
- Birth, Development, and Health
- Molecular Biology Techniques and Applications
- Peptidase Inhibition and Analysis
- Neonatal Respiratory Health Research
- Gene Regulatory Network Analysis
- Statistical Methods and Inference
- RNA Research and Splicing
- Melanoma and MAPK Pathways
- NF-κB Signaling Pathways
The University of Texas Southwestern Medical Center
2021-2025
Shenzhen Second People's Hospital
2020-2025
Shenzhen University Health Science Center
2020-2025
University of Oklahoma Health Sciences Center
2022-2025
Beijing Academy of Agricultural and Forestry Sciences
2018-2024
Nanjing Medical University
2024
Jiangsu Province Hospital
2024
Chengdu University of Traditional Chinese Medicine
2023
Shanghai Chest Hospital
2019-2022
Shanghai Jiao Tong University
2019-2022
The outbreak of 2019 novel coronavirus (2019-nCoV) pneumonia was reported in Wuhan, Hubei Province, China December and has spread internationally. This article discusses how radiology departments can most effectively respond to this public health emergency. On January 31, 2020, the World Health Organization declared a new as "Public Emergency International Concern (PHEIC)." February 13, officially named 2019-nCoV Corona Virus Disease-2019 Geneva, Switzerland. virus rapidly various cities...
Translocation Renal Cell Carcinoma (tRCC) most commonly involves an ASPSCR1-TFE3 fusion, but molecular mechanisms remain elusive and animal models are lacking. Here, we show that human driven by Pax8-Cre (a credentialed ccRCC driver) disrupted nephrogenesis glomerular development causing neonatal death, whilst the failed driver, Sglt2-Cre, induced aggressive tRCC (as well as ASPS) with complete penetrance short latency. However, in both contexts, led to characteristic morphological cellular...
Low-grade oncocytic tumor (LOT) of the kidney is a recently described entity with poorly understood pathogenesis. Using next-generation sequencing (NGS) and complementary approaches, we provide insight into its biology. We describe 22 LOT corresponding to 7 patients presenting median age 75 years (range 63–86 years) male female ratio 2:5. All tumors demonstrated prototypical microscopic features. Tumors were well-circumscribed solid. They composed sheets cells in compact nests. Tumor had...
Abstract The mechanisms underlying metastatic latency in renal cell carcinoma (RCC) remain poorly understood. This study evaluated two large independent cohorts for differences tumor biology between patients who developed metastases early (≤1 year after nephrectomy) and those with late-onset (>3 years). In the discovery cohort (n = 161), late-metastatic RCC (late-mRCC) was associated clear histology (88.9% vs 78.7%), lower pathological stage (pT1-2; 40.3% 18.0%), favorable...
It has been found that aberrant expression of microRNAs (miRNAs) is strongly associated with carcinogenesis. In the present study, we investigated miR-155 and miR-146a in diffuse large B-cell lymphoma (DLBCL) patients (n=90). The levels were significantly higher de novo DLBCL patients. miR-155, lactate dehydrogenase, β 2 microglobulin, c-myc, International Prognostic Index status Eastern Cooperative Oncology Group performance status. We low achieved a complete remission rate, overall...
N6-Methyladenosine (m6A) is the most abundant posttranscriptional modification, and its contribution to cancer evolution has recently been appreciated. Renal common adult genitourinary cancer, approximately 85% of which accounted for by clear cell renal carcinoma (ccRCC) subtype characterized VHL loss. However, it unclear whether loss in ccRCC affects m6A patterns. In this study, we demonstrate that binds promotes METTL3/METTL14 complex formation while depletion suppresses distinctive from...
Currently, little is known about the clinical relevance of tumor-stroma ratio (TSR) in chordoma and data discussing relationship between TSR immune status are lacking.To characterize distribution spinal chordoma, investigated its correlation with clinicopathologic or immunological features patients outcome.TSR was assessed visually on hematoxylin eosin-stained sections from 54 tumor specimens by 2 independent pathologists. Multiplex immunofluorescence used to quantify expression levels...
Combined antibiotic and heavy metal pollution has generated considerable concern. Constructed wetlands (CWs) have been shown to efficiently remove pollutants; however, the microbial community responses combined pollutants remain enigmatic. In this study, seven microcosm CWs were planted with Myriophyllum aquaticum, spiked tetracyclines (TCs) (300–30,000 μg/L), alone or Cu(II), investigate response of plant-associated communities. TCs Cu/TC ratio greatly affected performance CWs....
The endocycle is a variant cell cycle comprised of alternating gap (G) and DNA synthesis (S) phases (endoreplication) without mitosis (M), which results in polyploidy large size. Endocycles occur widely nature, but much remains to be learned about the regulation this modified cycle. Here, we compared gene expression profiles mitotic cycling larval brain disc cells with endocycling fat body salivary gland Drosophila larva. indicated that many genes are positively regulated by heterodimeric...
Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) and fibroblast growth factor-inducible molecule 14 (Fn14) are a ligand-receptor pair frequently overexpressed in solid tumors.Fn14 signaling regulates multiple oncogenic processes through MAPK, AKT, NFκB pathway activation. A phase I study RG7212, humanized anti-TWEAK IgG1κ monoclonal antibody, was conducted patients with advanced tumors expressing Fn14.Dose escalations, over 200- to 7,200-mg range, were performed enrolled...
Chromosomal patterning of gene expression in cancer can arise from aneuploidy, genome disorganization or abnormal DNA methylation. To map such patterns, we introduce a weighted univariate clustering algorithm to guarantee linear runtime, optimality and reproducibility.We present the chromosome method, establish its runtime evaluate performance. It uses dynamic programming enhanced with an reduce search-space in-place decrease overhead. Using delineated outstanding genomic zones 17 human...
The incidence of bone metastases in non-small cell lung cancer (NSCLC) patients is about 30-40% and bone-related events can seriously affect quality life. Immune checkpoint inhibitor (ICI) therapy has become the standard treatment for advanced NSCLC patients. However, specific efficacy ICIs with remains unclear. aim present study was to explore prognosis immunotherapy this population find potential biomarkers.In retrospective study, a total 110 who received pembrolizumab were enrolled....