A5100325935- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Salmonella and Campylobacter epidemiology
- Lung Cancer Treatments and Mutations
- Integrated Circuits and Semiconductor Failure Analysis
- Ferroptosis and cancer prognosis
- Cancer survivorship and care
- Viral gastroenteritis research and epidemiology
- Vibrio bacteria research studies
- Colorectal Cancer Surgical Treatments
- Peptidase Inhibition and Analysis
- Colorectal Cancer Treatments and Studies
- Chronic Lymphocytic Leukemia Research
- Colorectal and Anal Carcinomas
- Epigenetics and DNA Methylation
- Virus-based gene therapy research
- HER2/EGFR in Cancer Research
- Saffron Plant Research Studies
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Colorectal Cancer Screening and Detection
Yueyang Hospital
2019-2025
Shanghai University of Traditional Chinese Medicine
2019-2025
Shanxi Medical University
2025
Shenyang Agricultural University
2020-2025
Ministry of Agriculture and Rural Affairs
2025
Soil and Fertilizer Institute of Hunan Province
2025
Inner Mongolia University
2025
Sichuan Agricultural University
2025
Soochow University
2019-2024
First Affiliated Hospital of Soochow University
2019-2024
Background: With an increasing number of non-small cell lung cancer (NSCLC) patients being offered surgical treatment, postoperative rehabilitation is also increasingly emphasized. Traditional Chinese medicine (TCM) holds promise for enhancing recovery, with treatment methods still in refinement. This study aims to evaluate the efficacy herbal decoction and Liuzijue exercises NSCLC during rapid recovery period. Methods: A randomized, parallel-group clinical trial assigned 50 receive exercise...
Approximately 25% of breast cancers overexpress and depend on the receptor tyrosine kinase ERBB2, one 4 ERBB family members. Targeted therapies directed against ERBB2 have been developed used clinically, but many patients continue to develop resistance such therapies. Although much effort has focused elucidating mechanisms acquired ERBB2-targeted therapies, involvement ERBB4 remains elusive controversial. We demonstrate that genetic ablation ERBB4, not ERBB1-3, led apoptosis in...
The presence of polyfunctional CD4+ T cells is often associated with favorable antitumor immunity. We report here that persistent activation signal transducer and activator transcription 5 (STAT5) in tumor-specific drives the development cells. showed ectopic expression a constitutively active form murine STAT5A (CASTAT5) enabled to undergo robust expansion, infiltrate tumors vigorously, elicit CD8+ cell responses adoptive transfer model system. Integrated epigenomic transcriptomic analysis...
The braking mechanisms to protect the host from tissue damage and inflammatory disease caused by an overexuberant immune response are common in many T cell subsets. However, negative regulation of responses detailed not well understood early vertebrates. In current study, using a Nile tilapia (Oreochromis niloticus) model, we investigated suppression immunity IL-10. Tilapia encodes evolutionarily conserved IL-10, whose expression lymphocytes is markedly induced during primary adaptive...
Background The use of T cells expressing chimeric antigen receptor (CAR T) engineered to target CD19 constitutes breakthrough treatment for relapsed or refractory B cell non-Hodgkin lymphoma (R/R B-NHL). Despite improved outcomes, high relapse rate remains a challenge overcome. Here, we report the clinical results and pharmacokinetics bispecific CD19/22 CAR in patients with R/R B-NHL. Methods We performed prospective, single-arm study analyzed safety efficacy investigated kinetic profiles...
The systemic inflammatory response index (SIRI), a novel inflammation maker, has proven to be associated with prognostic outcomes in various diseases. However, few studies have been conducted assessing how SIRI may influence of patients on peritoneal dialysis (PD). Herein, we assessed the predictive value mortality all-cause mortality, including cardiovascular disease (CVD) PD patients.
Patients with relapsed or refractory (R/R) lymphomas have benefited from chimeric antigen receptor (CAR)-T-cell therapy. However, this treatment is linked to a high frequency of adverse events (AEs), such as cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity (ICANS), and hematologic toxicity. There has been increasing interest in hematological toxicity recent years, it can result additional complications, infection hemorrhage, which remain intractable.We conducted...
Campylobacter jejuni infection is a leading bacterial cause of gastroenteritis and common antecedent to Gullian-Barré syndrome. Our previous data suggested that the RNA-binding protein CsrA plays an important role in regulating several phenotypes including motility, biofilm formation, oxidative stress resistance. In this study, we compared proteomes wild type, csrA mutant, complemented mutant C. strains effort elucidate mechanisms by which affects virulence phenotypes. The putative regulon...
The incidence of bone metastases in non-small cell lung cancer (NSCLC) patients is about 30-40% and bone-related events can seriously affect quality life. Immune checkpoint inhibitor (ICI) therapy has become the standard treatment for advanced NSCLC patients. However, specific efficacy ICIs with remains unclear. aim present study was to explore prognosis immunotherapy this population find potential biomarkers.In retrospective study, a total 110 who received pembrolizumab were enrolled....
Mutation of the cj1461 predicted methyltransferase gene reduced motility Campylobacter jejuni 81-176. Electron microscopy revealed that mutant strain had flagella but with aberrant structure. The Deltacj1461 was sevenfold more adherent to 50-fold less invasive INT-407 human epithelial cells than wild type.
NPS6 is one of the nonribosomal peptide synthetase (NRPS) family members. The roles in ascomycetes are well known, but its Fusarium oxysporum unidentified. We investigated function growth, morphology, stress sensitivity, allelochemical secretion, and pathogenesis F. (FoNPS6). partial deletion FoNPS6 orthologs (ΔFON-NPS6) resulted hypersensitivity to H2O2 KO2, iron depletion, reduced virulence. Full virulence was restored by complementation. ΔFON-NPS6 not only inhibited spore formation also...
TAp73, a transcriptionally active isoform of the p73 gene, is essential for epithelial tissue development. Ferroptosis, regulated form cell death characterized by lipid peroxidation and reactive oxygen species (ROS) accumulation, has been increasingly studied in recent years. However, its role cells regulatory function TAp73 this context remain poorly understood. We investigated proliferation ferroptosis using ectopic overexpression RNA interference approaches. Cell was assessed through...
Patients with locally advanced rectal cancer typically receive neoadjuvant chemoradiation followed by total mesorectal excision. Other treatment approaches, including transanal techniques and close surveillance, are becoming increasingly common following positive responses to chemoradiation. Lack of pathologic lymph node staging is one major disadvantage these novel strategies.The purposes this study were determine clinicopathologic factors associated nodes for create a nomogram using...
Campylobacter jejuni is an important human pathogen that causes 96 million cases of acute diarrheal disease worldwide each year. We have shown C. CsrA involved in the post-transcriptional regulation more than 100 proteins, and altered expression these proteins presumably virulence-related phenotypes a csrA mutant. Mutation fliW results cells greatly truncated flagella, are less motile, able to form biofilms, exhibit reduced ability colonize chicks. The loss FliW 153 flagellar non-flagellar...
Abstract Hepatitis B virus‐related acute‐on‐chronic liver failure (HBV‐ACLF) is a syndrome with high short‐term mortality. The mechanism of the transcription factor ETS2 in ACLF remains unclear. This study aimed to clarify molecular basis pathogenesis. Peripheral blood mononuclear cells from patients HBV‐ACLF ( n = 50) were subjected RNA sequencing. Transcriptome analysis showed that expression was significantly higher than chronic diseases and healthy subjects (all p < 0.001)....
Wheat sharp eyespot caused by Rhizoctonia cerealis is primarily a severe threat to worldwide wheat production. Currently, there are no resistant cultivars, and the use of fungicides primary method for controlling this disease. Elucidating mechanisms R. pathogenicity can accelerate pace control Long intergenic noncoding RNAs (lincRNAs) that function in plant-pathogen interactions might provide new perspective. We systematically analyzed lincRNAs identified total 1,319 cerealis. found involved...
Introduction: As a highly aggressive tumor with poor prognosis, esophageal cancer (ESCA)'s relationship gene mutations is unclear. Therefore, we tried to explore the role of mutation in ESCA progression and its immune response, clinical treatment, prognosis. Methods: In addition copy number variation (CNV) situations common genes obtained from 2 public databases, between prognosis/tumor mutational burden (TMB) was also analyzed. Kaplan–Meier survival Cox regression analysis were used...
Drug combination therapies can improve drug efficacy, reduce dosage, and overcome resistance in cancer treatments. Current research strategies to determine which combinations have a synergistic effect rely mainly on clinical or empirical experience screening predefined pools of drugs. Given the number possible combinations, speed, scope find new are very limited using these methods. Due exponential growth it is difficult test all lab. There several large-scale public genomic phenotypic...
Saffron floral bio-residues (SFB) are a valuable natural source of antioxidants and dyes that can contribute to the development new food products cosmetic products. Color change was usually observed during SFB storage, which may result in quality degradation or even cause potential hazard human health. In order clarify mechanism color sample, chemical differences among samples stored under different conditions were analyzed using ultra-performance liquid chromatography coupled with...
Objective: The objective of the study was to observe and analyze characteristics negative emotions quality life (QoL) in patients with nonsmall cell lung cancer (NSCLC) from 1 3 months after surgery, summarize their population surgery. Materials Methods: consolidation rehabilitation period defined as main observation indicators were general Hospital Anxiety Depression Scale, European Organization for Research Treatment Cancer Core QoL Questionnaire (EORTC QLQ-C30), EORTC QLQ-Lung Cancer-13....