A5046778284- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Dermatologic Treatments and Research
- Thyroid Disorders and Treatments
- Systemic Sclerosis and Related Diseases
- Obstructive Sleep Apnea Research
- Calpain Protease Function and Regulation
- Prenatal Screening and Diagnostics
- Neuroscience of respiration and sleep
- Balance, Gait, and Falls Prevention
- Cancer, Lipids, and Metabolism
- Congenital Diaphragmatic Hernia Studies
- Biofield Effects and Biophysics
- Toxin Mechanisms and Immunotoxins
- Epigenetics and DNA Methylation
- Animal Virus Infections Studies
- Cancer Immunotherapy and Biomarkers
- Genomics and Rare Diseases
- Virology and Viral Diseases
- Software Testing and Debugging Techniques
Guangxi Medical University
2021-2025
Sichuan University
2003-2025
State Key Laboratory of Biotherapy
2018-2025
Nanchang Hangkong University
2009-2025
Mudanjiang Normal University
2023-2025
Education Department of Heilongjiang Province
2023-2024
Capital Medical University
2014-2024
Affiliated Hospital of Jiangsu University
2024
Lanzhou University
2024
Lanzhou University Second Hospital
2024
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide, but there are few effective treatments. Aberrant microRNA (miRNA) biogenesis correlated with HCC development. We previously demonstrated that peptidyl‐prolyl cis ‐ trans isomerase NIMA‐interacting 1 (Pin1) participates in miRNA and potential treatment target. However, how Pin1 modulates remains obscure. Here, we present vivo evidence overexpression directly linked to the development HCC. Administration inhibitor...
As a hot topic today, ferroptosis is closely involved in the progression and treatment of cancer. Accordingly, we built prognostic model around to predict overall survival OSCC patients. We used up 6 datasets from 3 different databases ensure credibility model. Then, through differentially expressed, Univariate Cox, Lasso regression analyses, composed nine prognostic-related differently expressed ferroptosis-related genes (CISD2, DDIT4, CA9, ALOX15, ATG5, BECN1, BNIP3, PRDX5 MAP1LC3A) were...
Copper, an indispensable trace element for the human body, serves not only as a crucial auxiliary factor in redox reactions within organism but also significant constituent of numerous key metabolic enzymes.The COMMD family plays vital role regulating copper at both cellular and systemic levels, particularly realm tumor research, area notably deficient gastric cancer investigations.With advancement precision medical techniques, individualized precise screening treatment have become paramount...
Summary Background and Aims Acne vulgaris is common in A sian populations. We compared three methods of phototherapy for the treatment moderate to severe facial acne C hinese patients. Methods Patients were randomly assigned receive photodynamic therapy ( PDT ), intense pulsed light IPL ) or blue–red light‐emitting diode LED right side face until inflammatory lesion count reduced by ≥ 90%. examined at 1 3 months after final treatment. Results enrolled 150 patients (92 males; mean age, 28...
Background: Considering the role of immunity and ferroptosis in invasion, proliferation treatment cancer, it is interest to construct a model prognostic-related differential expressed immune-related genes (PR-DE-IRFeGs), explore ferroptosis-related biological processes esophageal cancer (ESCA). Methods: Four ESCA datasets were used identify three PR-DE-IRFeGs for constructing prognostic model. Validation our was based on analyses internal external data sets, comparisons with past models....
Importance Currently, the diagnostic yield of exome sequencing (ES) and chromosomal microarray analysis (CMA) for short stature cohorts is uncertain. Despite previous studies reporting widespread use ES CMA, a definitive has not been established. Objective To investigate CMA in stature. Data Sources A systematic literature search was conducted using relevant keywords 3 databases (PubMed, Embase, Web Science) February 2023. Study Selection Eligible meta-analysis were those that had at least...
Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths globally, and the need for effective systemic therapies HCC urgent. Our previous work reveals that Pin1 potential anti-HCC target, which regulates miRNA biogenesis identifies API-1 as novel inhibitor to suppresses HCC. However, great demand in therapy well limited chemical stability pharmacokinetic feature motivated us find improved inhibitors. Herein, we designed synthesized diverse 6-O-benzylguanine derivatives...
In software development, debugging is the most tedious and time-consuming phase. Therefore, various automated fault localization techniques have been proposed to assist debugging. Among existing techniques, Spectrum-Based Fault Localization (SBFL) one of extensively researched methods. Traditional SBFL rely solely on coverage program execution for localization, which means they neglect interactions between entities propagation paths during program, resulting in a tie problem that reduces...
In this paper, high-purity zinc selenide (ZnSe) prepared by the Chemical Vapor Deposition (CVD) method was used as raw material, and iron ion-doped polycrystals were successfully fabricated through thermal diffusion at 1100 °C for 30 h. The results showed that ions (Fe2+) penetrated into crystals, but concentration of inside crystals relatively low, exhibited numerous defects. To address issue, we performed secondary sintering annealing on samples under high-temperature high-pressure (HPHT)...
Background: Due to the lack of accurate guidance biomarkers, treatment head and neck squamous cell carcinoma (HNSCC) has not been ideal. Ferroptosis plays an important role in tumor suppression patients. However, protein p53 (TP53) mutation may promote progression through ferroptosis. Therefore, it is particularly mine prognostic-related differentially expressed ferroptosis-related genes (PR-DE-FRGs) HNSCC construct a prognostic model for accurately guiding clinical treatment. Methods:...
Abstract Background Blue light in the 400–420 nm range has been shown to reduce levels of Propionibacterium acnes ( P. ) skin. postulated be a critical trigger for inflammatory acne. Thus, treatment with 420 nm‐intense pulsed should activity Aim To evaluate clinical and histological effects on acne animal model. Method Inflammation model was constructed by intradermal injection rat auricular. Levels tumour necrosis factor alpha (TNF‐α) matrix metalloproteinase 2 (MMP‐2), markers inflammation...
Abstract Peptidyl‐prolyl cis ‐ trans isomerase Pin1 plays a crucial role in the development of human cancers. Recently, we have disclosed that regulates biogenesis miRNA, which is aberrantly expressed HCC and promotes progression, indicating therapeutic therapy. Here, 7‐(benzyloxy)‐3,5‐dihydroxy‐2‐(4‐methoxyphenyl)‐8‐(3‐methylbut‐2‐en‐1‐yl)‐4H‐chromen‐4‐one ( AF‐39 ) was identified as novel inhibitor. Biochemical tests indicate potently inhibits activity with an IC 50 values 1.008 μ m , also...
UML activity diagram is suitable for modeling parallel and concurrent flows in an actual system. It also significant software testing. The subactivity state divides the into two kinds: atomic compound diagram, who constructs hierarchy of whole diagram. Dealing with a key issue during test case generation. This paper proposes method generating from to hierarchically introduces idea this by taking thought functional decomposition, bottom-up integration testing strategy round-robin strategy....
Abstract It has been demonstrated that circ_0001874 and circ_0001971 are potential biomarkers for the diagnosis of oral squamous carcinoma (OSCC). MiR-186 was reported to serve as a tumor suppressor in OSCC, down-regulation miR-186 lead higher expression oncogenic factor SHP2 activation growth promoting signaling. In this study, we aimed explore possible molecular role signaling pathogenesis OSCC. RT-qPCR, Western blot, online bioinformatics tools luciferase assay were utilized study...