A5108820456- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Single-cell and spatial transcriptomics
- Microbial Community Ecology and Physiology
- CAR-T cell therapy research
- Pancreatic and Hepatic Oncology Research
- Wastewater Treatment and Nitrogen Removal
- Cancer Genomics and Diagnostics
- Animal Virus Infections Studies
- Ovarian cancer diagnosis and treatment
- Gut microbiota and health
- Cancer Immunotherapy and Biomarkers
- Protist diversity and phylogeny
- Radiomics and Machine Learning in Medical Imaging
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Respiratory viral infections research
- Streptococcal Infections and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Caveolin-1 and cellular processes
- Microtubule and mitosis dynamics
- Mitochondrial Function and Pathology
- Plant Pathogenic Bacteria Studies
- Mycorrhizal Fungi and Plant Interactions
Shanghai Jiao Tong University
2023-2025
Xiamen University
2022-2025
Chongqing Medical University
2023-2025
Children's Hospital of Chongqing Medical University
2023-2025
Affiliated Hospital of Qingdao University
2021-2024
Nanjing Agricultural University
2020-2024
Guilin Medical University
2022-2024
Qingdao University
2021-2024
Spinal Cord Injury BC
2022-2024
Shanghai Cancer Institute
2023-2024
The Food and Drug Administration (FDA) has approved vaccines designed by GSK, Pfizer Moderna to protect high-risk populations against respiratory syncytial virus (RSV). These employ the pre-fusion F (pre-F) protein as immunogen. In this study, we explored an mRNA vaccine based on a modified pre-F called LC2DM-lipid nanoparticle (LC2DM-LNP). This features truncated version of that is anchored cell membrane. Our experiments in young old female mice revealed LC2DM-LNP elicited robust...
About a third of patients with relapsed or refractory classic Hodgkin lymphoma (r/r CHL) succumb to their disease after high-dose chemotherapy followed by autologous stem-cell transplantation (HDC/ASCT). Here, we aimed describe spatially resolved tumor microenvironment (TME) ecosystems establish novel biomarkers associated treatment failure in r/r CHL.
Pancreatic ductal adenocarcinoma (PDAC) features substantial matrix stiffening and reprogrammed glucose metabolism, particularly the Warburg effect. However, complex interplay between these traits their impact on tumor advancement remains inadequately explored. Here, we integrated clinical, cellular, bioinformatics approaches to explore connection stiffness effect in PDAC, identifying CLIC1 as a key mediator. Elevated expression, induced by through Wnt/β-catenin/TCF4 signaling, signifies...
Monitoring viral transmission and analyzing the genetic diversity of a virus are imperative to better understand its evolutionary history mechanism driving evolution spread. Especially, effective monitoring key antigenic mutations immune escape variants caused by these has great scientific importance. Thus, further molecular dynamics respiratory syncytial (RSV) circulating in China, we analyzed nasopharyngeal swab specimens derived from hospitalized children ≤5 years old with acute tract...
Cervical cancer remains the most prevalent gynecological malignant disease. Reprogramming tumor immune metabolism stands out as a novel promising therapeutic target. Here, we identified serine incorporator 2 (SERINC2) critical gene which highly expressed in cervical and negatively correlated with clinical outcomes. Through functional assays, SERINC2 was determined to play pro-tumoral role both vivo vitro. Besides, growth of cells found be largely dependent on manner influenced by SERINC2. As...
Background/Objectives: Concerns about the occurrence of autoimmune diseases are one main reasons influencing uptake human papillomavirus (HPV) vaccine. Limited evidence exists regarding relationship between HPV vaccination and risk Hashimoto’s thyroiditis (HT). Therefore, purpose this study was to examine association HT development in American women. Methods: Using National Health Nutrition Examination Survey (NHANES) data from 2007 2012, we conducted a cross-sectional 2717 women aged 18–59...
In soil ecosystems, fungi exhibit diverse biodiversity and play an essential role in biogeochemical cycling. Fungal diversity assembly processes across strata along altitudinal gradients are still unclear. this study, we investigated the structure abundance of fungal communities among elevational on Tibetan Plateau using Illumina MiSeq sequencing internal transcribed spacer1 (ITS1). The contribution neutral niche ecological were quantified a community model null model-based methodology. Our...
Wheat sharp eyespot caused by Rhizoctonia cerealis is primarily a severe threat to worldwide wheat production. Currently, there are no resistant cultivars, and the use of fungicides primary method for controlling this disease. Elucidating mechanisms R. pathogenicity can accelerate pace control Long intergenic noncoding RNAs (lincRNAs) that function in plant-pathogen interactions might provide new perspective. We systematically analyzed lincRNAs identified total 1,319 cerealis. found involved...
Abstract Chemotherapy resistance has been a great challenge in pancreatic ductal adenocarcinoma(PDAC) treatments. Current first-line chemotherapy regimens for PDAC include gemcitabine-based such as AG regimen (albumin paclitaxel and gemcitabine), fluorouracil-based regiments FOLFIRINOX ((5-fluorouracil5-FU), oxaliplatin, Irinotecan) platinum-based patients with BRCA mutations. large amounts of work have done on exploring the mechanism underlying regimens, while little research achieved...
Scoparone (SCO) has a wide range of pharmacological activities, especially antioxidant and lipid-lowering ones. The purpose this study was to investigate the effect SCO on alleviating liver injury induced by alcohol high-fat diet (HFD) in mice. pathomorphology, biochemical indices, lipid accumulation, metabolism, oxidative stress inflammatory response were examined. RNA sequencing analysis performed tissues identify differentially expressed genes (DEGs) signaling pathways, thus elucidating...
Congenital hypothyroidism (CH) is an neonatal endocrine disorder. Traditional newborn screening the mainstream method of CH screening, so as to ensure early detection and treatment CH. This limited it has high rates false positives negatives. Genetic can be used address shortcomings traditional Screening (NBS); however, comprehensive clinical value genetic yet systematically studied.A total 3,158 newborns who accepted were recruited for this study. Biochemical performed at same time. The...
Abstract As a preventable disease, cervical cancer (cervical squamous cell carcinoma and endocervical adenocarcinoma—CESC) remains tumor with high morbidity mortality worldwide, underscoring the pressing need for effective treatment strategies. This research identified Golgi transport 1B (GOLT1B) as critical gene involved in development of cancer. Gene Expression Omnibus (GEO) datasets were investigated to determine upregulation GOLT1B tissue compared normal tissue. Besides, was found...
An efficient protocol for the intermolecular amidoselenation of alkenes with diphenyl diselenides and alkyl amines has been developed, affording a series β-amido-selenides in high yields under copper salt (diacetoxyiodo)benzene (PI-DA) conditions.The preliminary experimental results supported involvement active selenide radical species, pathway was therefore proposed reaction.
Chronic hepatitis E virus (HEV) infection occurs mainly in immunosuppressed populations. We describe an investigation of chronic HEV genotype 3a individual without evidence for immune deficiency who presented with significant viremia and viral shedding. monitored RNA plasma stools, assessed anti-HEV specific responses. The patient was apparent immunodeficiency based on quantified results white blood cell, lymphocyte, neutrophilic granulocyte, CD3+ T CD4+ CD8+ cell counts CD4/CD8 ratio, as...
The plum rain season is a special climatic phenomenon in east Asia, which characterized by persistent rainfall, high temperature, and humidity, providing suitable environmental conditions for certain pathogenic bacteria, thus increasing the incidence of respiratory, gastrointestinal, urinary diseases. However, studies on human opportunistic bacteria communities during are still limited. In this study, characteristics bacterial daily necessities non-plum seasons were investigated using...
Abstract PURPOSE About a third of relapsed or refractory classic Hodgkin lymphoma (r/r CHL) patients succumb to their disease after high-dose chemotherapy followed by autologous stem cell transplantation (HDC/ASCT). Here, we aimed describe spatially resolved tumor microenvironment (TME) ecosystems establish novel biomarkers associated with treatment failure in r/r CHL. METHODS We performed imaging mass cytometry (IMC) on 169 paired primary diagnostic and relapse biopsies using marker panel...
Revealing the regional distribution and diversity of fungal sub-communities under different land management practices is essential to conserve biodiversity predict microbial change trends. In this study, a total 19 tilled 25 untilled soil samples across land-use types were collected from subtropical China investigate differences between spatial patterns, diversity, community assembly using high-throughput sequencing technology. Our results found that anthropogenic disturbances significantly...
<h3>Background</h3> The tumor microenvironment (TME) is the complex milieu of cells and molecules surrounding tumor. Single cell methods systems biology have been used to identify with pro- or anti-tumor properties, selectively modulating these has great therapeutic benefits in immunotherapy. However, there limited information on how spatial organization TME determines cells' signaling their potential. resolved computational analysis needed describe interactions effect patient outcomes....
7051 Background: The Bruton tyrosine kinase (BTK) inhibitor ibrutinib (ibr) has revolutionized the treatment of CLL, showing efficacy in majority patients. Nevertheless, resistance occurs a subset patients, often with dismal clinical outcomes. Ibr through several mechanisms, including mutations affecting BTK or PLCG2, upregulation alternative survival pathways. We investigated at single-cell level molecular mechanisms that underlie ibr CLL cells and their interactions non-malignant tumor...