A5101758494- Aquaculture disease management and microbiota
- interferon and immune responses
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Invertebrate Immune Response Mechanisms
- Reproductive System and Pregnancy
- Esophageal and GI Pathology
- T-cell and B-cell Immunology
- Antimicrobial Peptides and Activities
- Esophageal Cancer Research and Treatment
- Adipose Tissue and Metabolism
- Lung Cancer Diagnosis and Treatment
- Aquaculture Nutrition and Growth
- Healthcare and Venom Research
- Evolutionary Game Theory and Cooperation
- Chemokine receptors and signaling
- RNA modifications and cancer
- Peroxisome Proliferator-Activated Receptors
- Phytochemistry and Bioactivity Studies
- HER2/EGFR in Cancer Research
- Opinion Dynamics and Social Influence
- Radiomics and Machine Learning in Medical Imaging
- Cell Adhesion Molecules Research
- Physiological and biochemical adaptations
Shanghai Ocean University
2019-2025
Ministry of Science
2025
First Affiliated Hospital of Zhengzhou University
2024
Nanjing Medical University
2024
Yangzhou University
2024
Nanjing Maternity and Child Health Care Hospital
2024
Sun Yat-sen University
2024
Shenzhen University
2023
Guangdong Ocean University
2021
First Hospital of Shijiazhuang
2008
The braking mechanisms to protect the host from tissue damage and inflammatory disease caused by an overexuberant immune response are common in many T cell subsets. However, negative regulation of responses detailed not well understood early vertebrates. In current study, using a Nile tilapia (Oreochromis niloticus) model, we investigated suppression immunity IL-10. Tilapia encodes evolutionarily conserved IL-10, whose expression lymphocytes is markedly induced during primary adaptive...
Abstract The evolution processes of complex systems carry key information in the systems’ functional properties. Applying machine learning algorithms, we demonstrate that historical formation process various networked can be extracted, including protein-protein interaction, ecology, and social network systems. recovered has demonstrations immense scientific values, such as interpreting interaction network, facilitating structure prediction, particularly revealing co-evolution features...
Interleukin (IL)-22 plays an important role in regulating inflammation and clearance of infectious pathogens. IL-22 homologs have been discovered fish, but the functions sources not fully characterized. In this study, homolog was identified grass carp its bioactivities were investigated. The constitutively expressed tissues, with highest expression detected gills hindgut. It upregulated spleen after infection Flavobacterium columnare reovirus primary head kidney leukocytes stimulated LPS...
Interleukin (IL) 21 is a pleiotropic cytokine that plays an important role in regulating innate and adaptive immune responses. In fish, the biological functions cell source of IL-21 remain largely unknown. this study, we performed qRT-PCR, Western blotting immunofluorescent microscopy to examine expression at mRNA protein levels. We found il21 was induced primary head kidney leukocytes grass carp (Ctenopharyngodon idella) by heat-inactivated Aeromonas hydrophila (A. hydrophila) LPS tissues...
Abstract A balanced IFN response, tightly regulated at multiple levels, is essential for host defense against viral infection. Tripartite motif-containing (TRIM) proteins are a large group of E3 ubiquitin ligases, and have been shown to be involved in the regulation response. However, regulatory functions individual TRIM remain controversial. Here, we show that virus-inducible TRIM2 homolog acts as negative regulator production zebrafish. Zebrafish Trim2a was upregulated response spring...
Teleost type I interferons (IFNs) are categorized into group and II subgroups that bind to distinct receptors activate antiviral responses. However, the interaction between ifn ligands has not fully been understood. In this study, crystal structure of grass carp [ Ctenopharyngodon idella ( Ci )] IFNa solved at 1.58Å consists six helices. The displays a typical IFNs with straight helix F lacks element in AB loop. Superposition modeling identified several key residues involved receptors. It...
In mammals, interleukin (IL)-4 and IL-13 are important cytokines involved in the immune response of host defence against pathogens play critical roles polarization monocytes/macrophages (MO/Mϕs). However, teleost fish, role IL-4/13 homologues MO/Mϕ remains unknown. this paper, we identified a second isoform (CiIL-4/13A) from grass carp (Ctenopharyngodon idella) addition to homologue previously reported comparatively studied their expression profiles functions. The two CiIL-4/13 transcripts...
Abstract Gene duplication leads to subfunctionalization of paralogs. In mammals, IFN-γ is the sole member type II IFN family and binds a receptor complex consisting IFN-γR1 IFN-γR2. teleost fish, its receptors have been duplicated due teleost-specific whole-genome event. this study, functions an IFN-γ–related (IFN-γrel) cytokine were found be partially retained relative in grass carp (Ctenopharyngodon idella [CiIFN-γrel]). CiIFN-γrel upregulated expression proinflammatory genes but had lost...
Interferon regulatory factors (IRFs) are central in the regulation of interferon-mediated antiviral immunity. Here, we reported that IRF2a suppressed interferon response and promoted virus replication zebrafish.
After implementing the two-child policy, more Chinese women who had a previous delivery their second child. Nevertheless, impacts of parity on Gestational Diabetes (GDM) and macrosomia have not been fully confirmed. Therefore, we aimed to analyse characteristics pregnancy by evaluate association with risks GDM/macrosomia in population.