A5009042292- Renal and related cancers
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Ocular Diseases and Behçet’s Syndrome
- Bioinformatics and Genomic Networks
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Ferroptosis and cancer prognosis
- Corneal Surgery and Treatments
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Molecular Biology Techniques and Applications
- Corneal surgery and disorders
- Erythrocyte Function and Pathophysiology
- Parkinson's Disease Mechanisms and Treatments
- Connexins and lens biology
- Retinal Development and Disorders
- RNA Research and Splicing
The University of Texas Southwestern Medical Center
2011-2025
Southwestern Medical Center
2011-2025
Bayer (France)
2023
Takeda (United States)
2023
Ipsen (France)
2023
Foundation Medicine (United States)
2023
Harold C. Simmons Comprehensive Cancer Center
2023
University of Alabama at Birmingham
2020
Tulane University
2012-2019
Center for Excellence in Brain Science and Intelligence Technology
2016
MicroRNAs (miRNAs) modulate complex physiological and pathological processes by repressing expression of multiple components cellular regulatory networks. Here we demonstrate that miRNAs encoded the miR-23∼27∼24 gene clusters are enriched in endothelial cells highly vascularized tissues. Inhibition miR-23 miR-27 function locked nucleic acid-modified anti-miRNAs represses angiogenesis vitro postnatal retinal vascular development vivo. Moreover, required for a laser-induced choroidal...
Abstract Age-related macular degeneration (AMD) is a degenerative disease of the retina and leading cause blindness in elderly. Retinal pigment epithelial (RPE) cell death resultant photoreceptor apoptosis are characteristic late-stage dry AMD, especially geographic atrophy (GA). Although oxidative stress inflammation have been associated with GA, nature underlying mechanism for RPE remains controversial, which hinders development targeted therapy AMD. The purpose this study to...
microRNAs or miRs have been shown to be pivotal modulators of vascular development. The strand and cell type-specific function miR-126 in angiogenesis, especially pathological remains poorly defined. We characterized the retinal phenotype miR-126-/- mice, tested strands (miR-126-3p -5p) using vitro angiogenesis models a mouse model neovascular age-related macular degeneration. found that is critical for development but has dual angiogenesis. mice showed defective postnatal remodeling, which...
Metastasis is the principal cause of cancer related deaths. Tumor invasion essential for metastatic spread. However, determinants are poorly understood. We addressed this knowledge gap by leveraging a unique attribute kidney cancer. Renal tumors invade into large vessels forming tumor thrombi (TT) that migrate extending sometimes heart. Over decade, we prospectively enrolled 83 ethnically-diverse patients undergoing surgical resection grossly invasive at UT Southwestern Kidney Cancer...
Low-grade oncocytic tumor (LOT) of the kidney is a recently described entity with poorly understood pathogenesis. Using next-generation sequencing (NGS) and complementary approaches, we provide insight into its biology. We describe 22 LOT corresponding to 7 patients presenting median age 75 years (range 63–86 years) male female ratio 2:5. All tumors demonstrated prototypical microscopic features. Tumors were well-circumscribed solid. They composed sheets cells in compact nests. Tumor had...
Under normal conditions, the cornea is avascular, and this transparency essential for maintaining good visual acuity. Neovascularization (NV) of cornea, which can be caused by trauma, keratoplasty or infectious disease, breaks down so called 'angiogenic privilege' forms basis multiple pathologies that may even lead to blindness. Although there are several treatment options available, fundamental medical need presented corneal neovascular remains unmet. In order develop safe, effective,...
Actin cytoskeleton is critical for cell motility and division, both of which are important angiogenesis. MicroRNAs (miRNA/miR) emerging as pivotal modulators vascular development disease. How miRNAs regulate actin dynamics in endothelial cells (EC) neovascularization still unclear. Here, we report that miR-24 regulates ECs through targeting multiple members downstream Rho signaling, including Pak4, Limk2, Diaph1 proteins. Overexpression blocks stress fiber lamellipodia formation, represses...
CSiN score is an improved tool to assess the overall quality of tumor neoantigens that predicts response immunotherapy.
BackgroundClear cell renal carcinoma (ccRCC) is a particularly challenging tumor type because of its extensive phenotypic variability as well intra-tumoral heterogeneity (ITH). Clinically, this complexity has been reduced to handful pathological variables such stage, grade and necrosis, but these fail capture the breadth disease. How different phenotypes affect patient prognosis influence therapeutic response poorly understood. Extensive ITH illustrates remarkable plasticity, providing...
Abstract Glaucoma is a major cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP), which causes optic nerve damage and retinal ganglion cell death, the primary risk factor for in glaucoma patients. IOP controlled by balance between aqueous humor secretion from ciliary body (CB) its drainage through trabecular meshwork (TM). How microRNAs (miRs) regulate vivo largely unknown. Here we show that miR-143 miR-145 expression enriched smooth muscle eye. Targeted deletion /...
The in vivo function of microRNAs (miRs) diabetic retinopathy (DR) and age-related macular degeneration (AMD) remains unclear. We report here that let-7 family members are expressed retinal choroidal endothelial cells (ECs). In ECs, overexpression by adenovirus represses EC proliferation, migration, networking vitro, whereas inhibition the with a locked nucleic acid (LNA)-anti-miR has opposite effect. Mechanistically, silencing target HMGA2 gene mimics phenotype ECs. transgenic (let-7-Tg)...
Abstract Lung cancer, the leading cause of cancer mortality, exhibits diverse histologic subtypes and genetic complexities. Numerous preclinical mouse models have been developed to study lung but data from these are disparate, siloed, difficult compare in a centralized fashion. In this study, we established Cancer Autochthonous Model Gene Expression Database (LCAMGDB), an extensive repository 1,354 samples 77 transcriptomic datasets covering 974 genetically engineered (GEMM), 368...
<p>Identification of data redundancy by hierarchical clustering</p>
<p>Additional datasets, to be included in the next update of LCMAGDB</p>
<p>Depositor communications, describing input from data depositors</p>
<p>Dotplot of Ezh2 expression across various samples profiled by the Mouse430_2 microarray platform</p>
<p>Top 100 frequent genetic mutations in realworld lung cancer patients</p>
<div>Abstract<p>Lung cancer, the leading cause of cancer mortality, exhibits diverse histologic subtypes and genetic complexities. Numerous preclinical mouse models have been developed to study lung but data from these are disparate, siloed, difficult compare in a centralized fashion. In this study, we established Lung Cancer Autochthonous Model Gene Expression Database (LCAMGDB), an extensive repository 1,354 samples 77 transcriptomic datasets covering 974 genetically engineered...