A5040057250- Mesenchymal stem cell research
- Calcium signaling and nucleotide metabolism
- Autism Spectrum Disorder Research
- Advanced Sensor and Energy Harvesting Materials
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Cancer-related gene regulation
- Advanced Materials and Mechanics
- Neurogenesis and neuroplasticity mechanisms
- Polymer composites and self-healing
- Acute Ischemic Stroke Management
- Dermatological and COVID-19 studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Neuroscience of respiration and sleep
- Neurological Disease Mechanisms and Treatments
- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- Advanced Image Processing Techniques
- Oral microbiology and periodontitis research
- Multiple Sclerosis Research Studies
- Geochemistry and Geologic Mapping
- Generative Adversarial Networks and Image Synthesis
- COVID-19 Impact on Reproduction
- Angiogenesis and VEGF in Cancer
Cell Technology (China)
2016-2024
Zhujiang Hospital
2023
Shantou University
2022
Donghua University
2020-2021
GCI Science & Technology (China)
2021
Yancheng Institute of Technology
2019
Periodontitis is initiated by the infection of periodontal bacteria and subsequent tissue inflammation due to immunoreaction, eventually leading apparatus loss. Stem cells from human exfoliated deciduous teeth (SHEDs) have exhibited beneficial characteristics in dental regeneration. However, immunomodulatory functions SHEDs not been elucidated context periodontitis treatment. In this study, we investigated potential effects on experimental demonstrated that multidose delivery led...
Abstract Four-dimensional (4D) printing technology provides new ideas for the preparation and structural design of multifunctional shape memory composites. Excellent electrothermal behavior high recovery force are urgently demanded in practical applications. Herein, a continuous carbon fiber reinforced polylactic acid composite with strength, force, low-voltage response excellent was printed using dual nozzle 3D printer. The effects specimen thickness, content, applied voltage on were...
Recent literatures indicate that maternal hormone exposure is a risk factor for autism spectrum disorder (ASD). We hypothesize prenatal progestin may counteract the neuroprotective effect of estrogen and contribute to ASD development, we aim develop method ameliorate exposure-induced autism-like behavior. Experiment 1: Prenatal offspring are treated with resveratrol (RSV) through either or postnatal then used behavior testing other biomedical analyses. 2: norethindrone (NET) ERβ knockdown...
Autism spectrum disorder (ASD) is characterized by impairments in social communication and restricted or repetitive behaviors interests. ASD now diagnosed more than one out of 100 children biased towards males a ratio at least 4:1. Many possible explanations potential causative factors have been reported, such as genetics, sex, environmental factors, although the detailed mechanisms remain unclear. The dams were exposed through oral contraceptives to either vehicle control (VEH) alone,...
We have previously reported that prenatal progestin exposure induces autism-like behavior in offspring through ERβ (estrogen receptor β) suppression the brain, indicating may induce autism spectrum disorders (ASD). In this study, we aim to investigate whether is associated with ASD. A population-based case-control epidemiology study was conducted Hainan province of China. The ASD children were first screened Autism Behavior Checklist (ABC) questionnaire, and then diagnosed by clinical...
Abstract Coronavirus disease 2019 (COVID-19), driven by SARS-CoV-2, is a severe infectious that has become global health threat. Vaccines are among the most effective public tools for combating COVID-19. Immune status critical evaluating safety and response to vaccine, however, evolution of immune during immunization remains poorly understood. Single-cell RNA sequencing (scRNA-seq) represents powerful tool dissecting multicellular behavior discovering therapeutic antibodies. Herein,...
Abstract Neuromyelitis optica (NMO) is a severe autoimmune inflammatory disease of the central nervous system that affects motor function and causes relapsing disability. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have been used extensively in treatment various diseases, due to their potent regulatory roles can mitigate inflammation repair damaged tissues. However, use NMO currently limited, mechanism underlying beneficial effects hUC-MSCs on remains unclear. In this...
Pyroptosis, especially microglial pyroptosis, may play an important role in central nervous system pathologies, including traumatic brain injury (TBI). Transplantation of mesenchymal stem cells (MSCs), such as human umbilical cord MSCs (hUMSCs), has been a focus treatment. Recently, have found to many diseases by regulating the pyroptosis pathway. However, effect MSC transplantation on following TBI remains unknown. Tumor necrosis factor α stimulated gene 6/protein (TSG-6), potent...
Abstract Neuromyelitis optica spectrum disorder (NMOSD) is a severe inflammatory autoimmune disease of the central nervous system that manifested as secondary myelin loss. Oligodendrocyte progenitor cells (OPCs) are principal source myelinating oligodendrocytes (OLs) and abundant in demyelinated regions NMOSD patients, thus possibly representing cellular target for pharmacological intervention. To explore therapeutic compounds enhance myelination due to endogenous OPCs, we screened candidate...
The etiology of osteonecrosis the femoral head (ONFH) is not yet fully understood. However, ONFH a common disease with high morbidity, and approximately one-third cases are caused by glucocorticoids. We performed single-cell RNA sequencing bone marrow to explore effect glucocorticoid on ONFH. Bone samples proximal femur were extracted from four participants during total hip arthroplasty, including two diagnosed for systemic lupus erythematosus (SLE) treated glucocorticoids (the case group)...
Abstract The standard treatment for aplastic anemia (AA) in young patients is a matched sibling hematopoietic stem cell transplant. Transfusion of chronic AA patient with allogeneic bone marrow–derived mesenchymal stromal cells (BMMSCs) currently being developed as cell-based therapy, and the safety efficacy such transfusions are continuously improved. Nevertheless, mechanisms by which BMMSCs exert their therapeutic effects remain to be elucidated. In this study, (MSCs) obtained from marrow...
A novel Ag6Si2O7/CNTs composite photocatalyst was prepared by in-situ precipitation and characterized X-ray diffraction (XRD), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), ultraviolet-visible diffuse reflection (UV-vis DRS) photoluminescence (PLS). Photoelectric property photocatalytic activity were evaluated photocurrent (PC) methylene blue (MB) degradation. Photocatalytic of firstly increased then decreased with the increasing CNTs content. The degradation...
Intrathecal administration of human umbilical cord mesenchymal stem cells may be a promising approach for the treatment stroke, but its safety, effectiveness, and mechanism remain to elucidated. In this study, good manufacturing practice-grade (5 × 105 1 106 cells) saline were administered by cerebellomedullary cistern injection 72 hours after stroke induced middle cerebral artery occlusion in rats. The results showed (1) no significant difference mortality or general conditions among three...
Shadow removal and restoration of the image content in shadowed regions by using shadow has become more popular computer vision. But almost all current shadow-removal approaches use shadow-free images for training. Recently, an innovative approach that trains samples without this requirement due to method crops patches with shadows from images. However, it is insufficient directly learn essential relationships between domains adversarial learning cycle-consistency constraints. Moreover,...