A5101648743- Mesenchymal stem cell research
- Neuroinflammation and Neurodegeneration Mechanisms
- Polysaccharides and Plant Cell Walls
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Advanced Glycation End Products research
- Seaweed-derived Bioactive Compounds
- Potato Plant Research
- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- Edible Oils Quality and Analysis
- Autophagy in Disease and Therapy
- Fungal Biology and Applications
- Immune cells in cancer
- Phytochemicals and Medicinal Plants
- Metabolomics and Mass Spectrometry Studies
- Cassava research and cyanide
- Crystallography and molecular interactions
- Polymer Science and PVC
- Barrier Structure and Function Studies
- Photodynamic Therapy Research Studies
- Neurological Disorders and Treatments
- Concrete and Cement Materials Research
- Petroleum Processing and Analysis
- Erythrocyte Function and Pathophysiology
Anhui University
2021-2025
Guangzhou Women and Children Medical Center
2024
Guangzhou Medical University
2024
Zhujiang Hospital
2016-2023
Shenzhen University
2021-2022
Southern Medical University
2016-2021
Beijing Technology and Business University
2020
Shanghai Jiao Tong University
2015-2019
Northwest A&F University
2013
To investigate the therapeutic mechanism of action transplanted stem cells and develop exosome-based nanotherapeutics for ischemic stroke, we assessed effect exosomes (Exos) produced by human umbilical cord mesenchymal (hUMSCs) on microglia-mediated neuroinflammation after stroke. Our results found that injected hUMSC-Exos were able to access site damage could be internalized both
Tumor initiating cells or cancer stem (CSCs) play an important role in the initiation, development, metastasis, and recurrence of tumors. However, traditional therapies have limited effects against CSCs targeting these is crucial when developing new therapeutic strategies cancer. One potentially targetable factor CD47, a member immunoglobulin superfamily. This protein acts as anti-phagocytic "don't eat me" signal often found expressed by cells, particularly CSCs. CD47 functions activating...
Glioblastoma (GBM), one of the most malignant brain tumors in world, has limited treatment options and a dismal survival rate. Effective safe disease-modifying drugs for glioblastoma are urgently needed. Here, we identified small molecule, Molephantin (EM-5), effectively penetrated blood-brain barrier (BBB) demonstrated notable antitumor effects against GBM with good safety profiles both vitro vivo. Mechanistically, EM-5 not only inhibits proliferation invasion cells but also induces cell...
This study investigated whether and how triacylglycerol (TAG) may serve as a precursor for 3-monochloro-1,2-propanediol (3-MCPD) fatty acid ester formation using tristearoylglycerol (TSG). TSG was reacted with inorganic chloride compounds including NaCl, KCl, FeCl2, CuCl2, ZnCl2, FeCl3 dry HCl, or organic chlorine compound lindane at different temperatures. Only FeCl2 were able to form 3-MCPD esters from TSG. Further electron spin resonance (ESR) determination of TSG, Fe2(SO4)3...
Bone mesenchymal stem cells (BMSCs) death after transplantation is a serious obstacle impacting on the outcome of cell therapy for cerebral infarction. This study was aimed to investigate whether modification BMSCs with Hif-1α could enhance survival implanted BMSCs. were isolated from Wistar rats, and infected Hif-1α-GFP lentiviral vector or siRNA. The modified exposed oxygen-glucose deprivation (OGD) condition, cellular viability apoptosis then assessed. An inhibitor AMPK (compound C) used...
Formation of 3-monochloropropanediol (3-MCPD) esters from monostearoyl glycerol (MSG) was investigated under high temperature and low moisture conditions. Different organic inorganic chlorides, including lindane, KCl, CaCl2, NaCl, MgCl2, AlCl3, CuCl2, MnCl2, SnCl2, ZnCl2, FeCl3, were evaluated for their potential to react with MSG form 3-MCPD glycidyl at 120 240 °C using a UPLC-Q-TOF MS analysis. The results indicated that different chlorine compounds differed in capacity formed products...
Abstract Three medium‐ and long‐chain triacylglycerols (MLCT) with different contents of medium‐chain fatty acids (MCFA) (10% to 30%, w/w) were prepared evaluated for their anti‐obesity potential in C57BL/6J mice. The group fed a high fat diet MLCT containing 30% (w/w) MCFA showed significantly decreased body weight mass ( P < 0.05) relative the control mice an obesity‐inducing rapeseed oil diet. In addition, serum parameters including triacylglycerols, total cholesterol, glucose,...
In this work, a stable isotope dilution ultrahigh-performance liquid chromatography triple quadrupole tandem mass spectrometry (UHPLC–QqQ-MS/MS) method was developed and validated for simultaneous determination of Nε-(carboxymethyl)lysine (CML), Nε-(carboxyethyl)lysine (CEL), acrylamide (AA) in baked fried foods. Ground food samples were extracted with acetone followed by two parallel assays. assay A, cleanup procedure based on dispersive solid-phase extraction conducted AA, free CML, CEL...
Pyroptosis, especially microglial pyroptosis, may play an important role in central nervous system pathologies, including traumatic brain injury (TBI). Transplantation of mesenchymal stem cells (MSCs), such as human umbilical cord MSCs (hUMSCs), has been a focus treatment. Recently, have found to many diseases by regulating the pyroptosis pathway. However, effect MSC transplantation on following TBI remains unknown. Tumor necrosis factor α stimulated gene 6/protein (TSG-6), potent...
Fatty acid esters of monochloropropane 1,2-diol (3-MCPD) are processing-induced toxicants and have been detected in several food categories. This study investigated the absorption, distribution, metabolism, excretion 3-MCPD Sprague-Dawley (SD) rats using 1-monopalmitate as probe compound. The kinetics plasma was SD rats, results indicated that absorbed directly vivo metabolized. Its primary metabolites liver, kidney, testis, brain, plasma, urine were tentatively identified measured at 6, 12,...
Abstract BACKGROUND Polysaccharides from Pleurotus citrinopileatus exhibit diverse bioactivities, yet their efficacy against ultraviolet B (UVB)‐induced photoaging remains unexplored. This study aimed to purify and characterize a specific PCP assess its protective effects using UVB‐induced zebrafish model. RESULTS A polysaccharide, designated as PCP‐2, was isolated P. through hot‐water extraction, ultrafiltration chromatography. PCP‐2 is galactoglucan with molecular weight of 1.52 × 10 6 Da,...
The Maillard reaction (MR) can affect the color, flavor, organoleptic properties, and nutritional value of food. Sometimes, MR is undesirable due to lowering nutrient utilization, producing harmful neo-formed compounds, etc. In this case, it necessary control MR. Some chemical substances, such as phenolic acid, vitamins, aminoguanidine, thiols extracted from garlic or onion, effectively prevent study, L-cysteine (L-cys) was found inhibit after screening 10 sulfhydryl compounds by comparing...
In this study, we investigated interactions among microglia (MG), bone marrow mesenchymal stem cells (BMSCs) and neurons in cerebral ischemia the potential mechanisms using an vitro oxygen-glucose deprivation (OGD) model. Rat BMSCs were incubated with conditioned medium (CM) from cultures of OGD-activated rat MG murine BV2 cells. Effects glial cell-derived neurotrophic factor (GDNF) on neuron viability, apoptosis, lactate dehydrogenase (LDH) leakage mitochondrial membrane (MMP) analyzed...
Abstract The use of fungal polysaccharides as immunomodulators has garnered significant interest. Here, the polysaccharide PCP‐1 is isolated and purified from fruiting bodies Pleurotus citrinopileatus . identified a glucan with molecular weight 1670 kDa. Methylation analysis reveals that consists T‐Glc p , T‐Rha 1,3‐Glc 1,4‐Glc 1,4,6‐Glc 1,3,6‐Glc exhibits exceptional immunomodulatory effects, it can dose‐dependently stimulate phagocytosis promote secretion nitric oxide reactive oxygen...