Berry fruits are widely consumed in our diet and have attracted much attention due to their potential human health benefits. Berries contain a diverse range of phytochemicals with biological properties such as antioxidant, anticancer, anti-neurodegerative, anti-inflammatory activities. In the current study, extracts six popularly berriesblackberry, black raspberry, blueberry, cranberry, red raspberry strawberrywere evaluated for phenolic constituents using high performance liquid...

A number of different beverage products claim to have antioxidant potency due their perceived high content polyphenols. Basic and applied research indicates that pomegranate juice (PJ), produced from the Wonderful variety Punica granatum fruits, has strong activity related health benefits. Although consumers are familiar with concept free radicals antioxidants, they often misled by claims superior beverages, which usually based only on testing a limited spectrum activities. There is no...

An overwhelming body of research has now firmly established that the dietary intake berry fruits a positive and profound impact on human health, performance, disease. Berry fruits, which are commercially cultivated commonly consumed in fresh processed forms North America, include blackberry ( Rubus spp.), black raspberry occidentalis), blueberry Vaccinium corymbosum), cranberry (i.e., American cranberry, macrocarpon, distinct from European V. oxycoccus), red idaeus) strawberry Fragaria x...

Phytochemicals from fruits such as the pomegranate (Punica granatum L) may inhibit cancer cell proliferation and apoptosis through modulation of cellular transcription factors signaling proteins. In previous studies, juice (PJ) its ellagitannins inhibited induced in HT-29 colon cells. The present study examined effects PJ on inflammatory proteins human line. At a concentration 50 mg/L significantly suppressed TNFα-induced COX-2 protein expression by 79% (SE = 0.042), total tannin extract...

Abstract Purpose: Phytochemicals in plants may have cancer preventive benefits through antioxidation and via gene-nutrient interactions. We sought to determine the effects of pomegranate juice (a major source antioxidants) consumption on prostate-specific antigen (PSA) progression men with a rising PSA following primary therapy. Experimental Design: A phase II, Simon two-stage clinical trial for after surgery or radiotherapy was conducted. Eligible patients had detectable >0.2...

Cranberries (Vaccinium macrocarpon Ait.) are an excellent dietary source of phytochemicals that include flavonol glycosides, anthocyanins, proanthocyanidins (condensed tannins), and organic phenolic acids. Using C-18 Sephadex Lipophilic LH-20 column chromatography, HPLC, tandem LC-ES/MS, the total cranberry extract (TCE) has been analyzed, quantified, separated into fractions enriched in sugars, acids, polyphenols, proanthocyanidins, anthocyanins (39.4, 30.0, 10.6, 5.5, 1.2% composition,...

Studies suggest that consumption of berry fruits, including strawberries ( Fragaria x ananassa Duch.), may have beneficial effects against oxidative stress mediated diseases such as cancer. Berries contain multiple phenolic compounds, which are thought to contribute their biological properties. Comprehensive profiling phenolics from was previously reported using high-performance liquid chromatography with mass spectrometry (HPLC-MS) detection. The current study reports the isolation and...

Gold and copper nanoparticles have been widely investigated for photothermal therapy of cancer. However, degradability toxicity these remain concerns. Here, we compare hollow CuS (HCuSNPs) with gold nanospheres (HAuNS) in similar particle sizes morphology following intravenous administration to mice. The injected pegylated HCuSNPs (PEG-HCuSNPs) are eliminated through both hepatobiliary (67 percentage dose, %ID) renal (23 excretion within one month postinjection. By contrast, 3.98 %ID Au is...

Pomegranate shows neuroprotective effects against Alzheimer's disease (AD) in several reported animal studies. However, whether its constituent ellagitannins and/or their physiologically relevant gut microbiota-derived metabolites, namely, urolithins (6H-dibenzo[b,d]pyran-6-one derivatives), are the responsible bioactive constituents is unknown. Therefore, from a pomegranate extract (PE), previously by our group to have anti-AD vivo, 21 constituents, which were primarily ellagitannins,...

Our group has shown in a phase II clinical trial that pomegranate juice (PJ) increases prostate specific antigen (PSA) doubling time cancer (CaP) patients with rising PSA. Ellagitannins (ETs) are the most abundant polyphenols present PJ and contribute greatly towards its reported biological properties. On consumption, ETs hydrolyze to release ellagic acid (EA), which is then converted by gut microflora 3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one (urolithin A, UA) derivatives. Despite...

The health benefits associated with tea consumption have resulted in the wide inclusion of green extracts botanical dietary supplements, which are widely consumed as adjuvants for complementary and alternative medicines. Tea contains polyphenols such catechins or flavan-3-ols including epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate (EGCG), well alkaloid, caffeine. Polyphenols antioxidants, EGCG, due to its high levels, is accepted major antioxidant tea....

The bioactive anthocyanins present in tart cherries, Prunus cerasus L. (Rosaceae) cv. Balaton, are cyanidin 3-glucosylrutinoside (1), 3-rutinoside (2), and 3-glucoside (3). Cyanidin (4) is the major anthocyanidin cherries. In our continued evaluation of vivo vitro efficacy these to prevent inflammation colon cancer, we have added compounds McCoy's 5A medium an effort identify their degradation products during cell culture studies. This resulted isolation characterization protocatechuic acid...

The antioxidant activities of a series commonly consumed and biogenetically related plant phenolics, namely, anthocyanidins, anthocyanins, catechins, in liposomal model system have been investigated. efficacies the compounds were evaluated on their abilities to inhibit fluorescence intensity decay an extrinsic probe, 3-[p-(6-phenyl)-1,3,5-hexatrienyl]phenylpropionic acid, caused by free radicals generated during metal ion-induced peroxidation. Distinct structure−activity relationships...

Cornus mas, officinalis, controversa, and kousa (Cornaceae) bear edible fruits that are consumed in parts of Europe Asia. This study undertook the investigation presence levels anthocyanins these species by HPLC. The present Cornelian cherries, C. delphinidin 3-O-β-galactopyranoside (1), cyanidin (2), pelargonidin (3). officinalis contains only 1−3, similar to but different proportions. However, controversa 1−3 among other anthocyanins, Chinese dogwood, kousa, did not contain 1−3. contents...

Dietary phytochemicals are known to exhibit a variety of anticarcinogenic properties. This study investigated the chemopreventive activity blueberry extract in triple-negative breast cancer cell lines vitro and vivo. Blueberry decreased proliferation HCC38, HCC1937, MDA-MB-231 cells with no effect on nontumorigenic MCF-10A line. Decreased metastatic potential by was shown through inhibition motility using wound-healing assays migration polyethylene terephthalate membrane. treatment matrix...

Abstract Estrogen stimulates the proliferation of breast cancer cells and growth estrogen-responsive tumors. The aromatase enzyme, which converts androgen to estrogen, plays a key role in carcinogenesis. pomegranate fruit, rich source ellagitannins (ET), has attracted recent attention due its anticancer antiatherosclerotic properties. On consumption, ETs hydrolyze, releasing ellagic acid, is then converted 3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one (“urolithin”) derivatives by gut microflora....