A5040465040- Cancer-related molecular mechanisms research
- Shoulder Injury and Treatment
- Bone Tissue Engineering Materials
- Surgical Sutures and Adhesives
- Electrospun Nanofibers in Biomedical Applications
- Tendon Structure and Treatment
- Extracellular vesicles in disease
- Orthopaedic implants and arthroplasty
- Bone health and treatments
- RNA modifications and cancer
- MicroRNA in disease regulation
- Total Knee Arthroplasty Outcomes
- Inflammation biomarkers and pathways
- Polymer Surface Interaction Studies
- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Neuroinflammation and Neurodegeneration Mechanisms
- Curcumin's Biomedical Applications
- Knee injuries and reconstruction techniques
- Wound Healing and Treatments
- Occupational Health and Performance
- Circular RNAs in diseases
- Signaling Pathways in Disease
- Heat shock proteins research
- Autophagy in Disease and Therapy
Sun Yat-sen University
2015-2025
Third Affiliated Hospital of Sun Yat-sen University
2015-2025
National University Health System
2015
National University of Singapore
2015
Mesenchymal stem cells (MSCs) have been described to induce angiogenesis in various tissues and used for the development of novel cell‐based therapies. Increasing evidence suggests that MSCs execute their paracrine function via secretion exosomes, especially under hypoxic conditions. However, mechanisms by which MSC‐derived exosomes secreted hypoxia enhance still remain unclear. To study exosome physiology or normoxic conditions, we isolated from bone marrow mesenchymal (BMSCs). Furthermore,...
Triggering receptor expressed on myeloid cell 2 (TREM2) signaling often drives opposing effects in traumatic versus demyelinating CNS disorders. Here, we identify two distinct phenotypes of microglia and infiltrating populations dependent TREM2 expression levels at the acute stage elucidate how they mediate spinal cord injury (SCI) multiple sclerosis animal models (experimental autoimmune encephalomyelitis [EAE]). High sustain phagocytic macrophages after SCI. In contrast, moderate...
Fibrous encapsulation that prevents the direct contact between an implant and bone can cause failure.
Autograft microskin transplantation has been widely used as a skin graft therapy in full-thickness defect. However, grafting failure can lead to pathological delay wound healing due poor vascularization bed. Considering the active role of adipose-derived stem cell (ADSC) promoting angiogenesis, we intend investigate efficacy autograft combined with ADSC for facilitating defect mouse model.
Abstract Osteosarcoma (OS) is the most common primary solid malignant bone tumor, and its metastasis a prominent cause of high mortality in patients. In this study, prognosis risk signature was constructed based on metastasis‐associated genes. Four microarrays datasets with clinical information were downloaded from Gene Expression Omnibus, 256 genes identified by limma package. Further, protein‐protein interaction network constructed, survival analysis performed using data Therapeutically...
Gap balancing is a vital process during mobile-bearing unicompartmental knee arthroplasty (MB-UKA). However, this commonly depends on the surgeon's experience and lacks specific unified standards. This study aimed to propose evaluate novel "measured resection" method for gap balance in MB-UKA. prospective included 49 consecutive patients (52 knees) who underwent MB-UKA from February 1, 2023, September 2023. was achieved by traditional "two-finger" (Group 26 or measured resection 2, knees)....
Joint contracture (also known as arthrofibrosis) is a fibrotic joint disorder characterized by excessive collagen production to form scar tissue and adhesions within capsules. This can severely affect day‐to‐day activities quality of life because restricted range motion in affected joints. The precise pathogenic mechanism underlying contractures not fully understood. Lumican belongs the class II small leucine‐rich repeat proteoglycan superfamily, which makes up fibrils extracellular matrix....
This research was set up to determine the efficacy of a synthetic biomimetic skin substitute poly-L-lactide (PLLA)/gelatin nanofiber membrane in facilitating chronic cutaneous wound healing. The material physical properties and biological characteristics were evaluated. safety effectiveness further confirmed by clinical applications. Results indicated that average diameter nano pores 0.65 μm. mean contact angle 80.39°, tensile strength 4.42 ± 0.43 MPa. proliferation fibroblasts monocytes...
Joint contracture is a fibrous disease characterized as joint capsule fibrosis that results in dysfunction and disability. The purpose of this study was to analyze the biological activities chaperonin containing T-complex polypeptide (CCT) subunits determine role CCT chaperone rat model.In study, model established by immobilizing knee for 8 weeks. Then, fibroblasts were isolated from posterior cultured functional analysis such qRT-PCR, Western blot, transwell assay, collagen assay. effect...
Failing to regenerate native tendon tissue in chronic massive rotator cuff tears (CMRCTs) results high retear rates after surgery. Gelatin is a hydrolyzed form of collagen which bioactive and biocompatible. This study intends investigate the suitability integrating gelatin poly (l-lactic acid) (PLLA) fibrous membranes for promoting healing CMRCTs. PLLA/Gelatin electrospun (PGEM) are fabricated using electrospinning technology. The fourier transform infrared, static contact angles tested...
Joint contracture is a fibrotic complication induced by joint immobilization and trauma, which characterized as excessive myofibroblast proliferation in capsule. The treatments of are unsatisfied patients suffered from dysfunction. Our previous study has shown that curcumin can inhibit vitro, but the major challenge low aqueous solubility biological activity curcumin. In this study, hyaluronic acid-curcumin (HA-Cur) conjugate was synthesized to suppress myofibroblasts contracture. Cells were...
Joint contracture is increasingly regarded as a clinical problem that leads to irreversible dysfunction of the joint. It pathophysiological process following joint injury, which marked by activation myofibroblasts. There currently no effective treatment for prevention contracture. Curcumin polyphenol pigment extracted from turmeric, possesses anti-inflammatory, antioxidative, and antitumor properties. In present study, we demonstrated curcumin exerts protective effect against via inhibition...
Osteosarcoma is the most common bone sarcoma in adolescents. Decorin (DCN) has been proposed to be a new anti-osteosarcoma therapeutic strategy. Our previous study loaded decorin on titanium (Ti) surface by polydopamine (DOPA) as an anchor enhance osseointegration. In this study, we investigated effect of decorin-coated Ti substrates (TI-DOPA-DCN) oncogenic potential osteosarcoma cells SAOS-2. The were placed 24-well plates for cell culture. Cell viability was determined Counting Kit-8...
Joint contracture is a fibroproliferative disorder that restricts joint mobility, resulting in tissue degeneration and deformity. However, the etiology of still unknown. Chaperonin containing T-complex polypeptide subunit eta (CCT-eta) reported to increase fibrotic diseases. The purpose this study was investigate whether CCT-eta implicated determine role progression by analyzing rat model. We immobilized left knee internal fixation for 8 weeks. non-immobilized right leg served as control....
Abstract Ferroptosis has emerged as a deliberate type of programmed cell death that manifests marked importance ubiquitously in health and diseases. However, after decade research, the mechanisms ferroptosis execution remain unclear. Here we identify chloride ions (Cl - ) essential determinants ferroptosis. Water homeostasis manipulated by extracellular solute concentration disrupts ferroptotic death. Hyperosmotic stress attenuates endues cells with high lipid peroxidation. Analyses...
Osteosarcoma is a highly malignant bone cancer which primarily occurs in children and young adults. Increasing evidence indicates that long noncoding RNAs (lncRNAs), function as competing endogenous (ceRNAs) sponge microRNAs (miRNAs) messenger (mRNAs), play pivotal role the pathogenesis progression of cancers. The regulatory mechanisms lncRNA-mediated ceRNAs osteosarcoma have not been fully elucidated. In this study, we identified differentially expressed lncRNAs, miRNAs, mRNAs based on RNA...
Rotator cuff tear of shoulder is a common tendon injury. Current therapeutic strategies are unsatisfactory because poor biomechanical properties the repaired rotator tendons. To solve this problem, newly biofabricated tenogenic patch by uniaxial cold-drawing technology was applied for treatment acute and its effects were evaluated in vitro vivo. The cytocompatibility results indicated that engineered capable promoting spreading, migration proliferation fibroblasts vitro. Stress–strain curves...