Idiopathic pulmonary fibrosis (IPF) is a highly lethal pathological process that characterized by inflammation, fibroblast accumulation, and excessive collagen deposition. Although AKT2-mediated signaling pathways modulate inflammatory responses, their role in IPF has not been defined. We report AKT2 deficiency (Akt2-/-) protected against bleomycin-induced inflammation. Adoptive transfer of wild-type macrophages or administration IL-13 to Akt2-/- mice could restore fibrosis. In response...

Cancer-associated fibroblasts (CAFs) have been implicated in the development of resistance to anticancer drugs; however, role and mechanism underlying CAFs luminal breast cancer (BrCA) tamoxifen are unclear. We found that stromal isolated from central or peripheral area BrCA similar CAF phenotype activity. In vitro vivo experiments showed derived clinical–luminal BrCAs induce through decreasing estrogen receptor-α (ER-α) level when cultured with cell lines MCF7 T47D. promoted interleukin-6...

Coronavirus disease 2019 (COVID-19) is one of the most destructive pandemic after millennium, forcing world to tackle a health crisis. Automated lung infections classification using chest X-ray (CXR) images could strengthen diagnostic capability when handling COVID-19. However, classifying COVID-19 from pneumonia cases CXR image difficult task because shared spatial characteristics, high feature variation and contrast diversity between cases. Moreover, massive data collection impractical for...

The proinflammatory factor high‑mobility group box protein 1 (HMGB1) has been implicated in the pathogenesis of lung fibrosis; however, role HMGB1 fibrosis remains unclear. It previously reported that nuclear (NF)‑κB and transforming growth (TGF)‑β1 may be involved fibrosis. Therefore, present study aimed to examine potential molecular mechanisms underlie HMGB1‑induced via regulation NF‑κB TGF‑β1. results demonstrated stimulation increased activation release TGF‑β1, as well expression...

Recurrent tracheoesophageal fistula (rTEF) is a complex complication after the repair of esophageal atresia (EA) and remains challenge because difficulties in preoperative management substantial rates mortality morbidity reoperation. By reviewing single institution's experience rTEF assessing outcome, we aimed to provide an optimal approach for managing evaluate growth feeding problems reoperations. The medical records 35 patients with treated at institution from June 2012 December 2015 were...

Although hypoxia-inducible factor-lα (HIF-lα) has been reported to have an important role in the metabolism and synthesis of extracellular matrix (ECM) nucleus pulposus cells (NPCs), underlying mechanism not fully clarified. Here, we show for first time that NOTCH1 expression is decreased NPs isolated from degenerated human intervertebral discs (IVDs), as well NP-specific HIF-1α−/− mice. Our study reveals overexpression HIF-1α leads increased NOTCH1, ligand JAGGED1, its target gene hairy...

Abstract In this study, we identified the multifaceted effects of atezolizumab, a specific monoclonal antibody against PD-L1, in tumor suppression except for restoring antitumor immunity, and investigated promising ways to improve its efficacy. Atezolizumab could inhibit proliferation induce immune-independent apoptosis osteosarcoma cells. With further exploration, found that atezolizumab impair mitochondria cells, resulting increased release reactive oxygen species cytochrome-c, eventually...

Pneumothorax is a life-threatening emergency that requires immediate treatment. Frontal-view chest X-ray images are typically used for pneumothorax detection in clinical practice. However, manual review of radiographs time-consuming, labor-intensive, and highly dependent on the experience radiologists, which may lead to misdiagnosis. Here, we aim develop reliable automatic classification method assist radiologists rapidly accurately diagnosing frontal radiographs.A novel residual neural...

Epidermal growth factor receptor gene (EGFR) mutations are among the best predictive markers of efficacy EGFR tyrosine kinase inhibitor (EGFR-TKI) treatment. Mutations in confer sensitivity to EGFR-TKIs patients with advanced non-small cell lung cancer (NSCLC). This study determined concordance rate serum samples and tumour tissue from Chinese NSCLC compared two detection methods: mutant-enriched polymerase chain reaction-based DNA sequencing non-enriched sequencing. The mutation status was...

Emerging evidence suggests that suberoylanilide hydroxamic acid (SAHA), a clinically approved HDAC inhibitor for cutaneous T-cell lymphoma, shows promising clinical benefits in neuroblastoma, the most common extra cranial solid neoplasm with limited choice of therapeutic intervention. However, molecular mechanism under which compound exerts its antitumor effect remains elusive. Here we report quantitative proteomics study determines changes protein expression, histone lysine acetylation, and...

Abstract Intestinal inflammation plays a critical role in the pathogenesis of intestinal failure (IF). The macrophages are essential to maintain homeostasis. However, underlying mechanisms activation remain poorly understood. Since microRNAs (miRNAs) have pivotal roles regulation immune responses, here we aimed investigate miR-124 macrophages. In this study, showed that increased pediatric IF patients and resulted induction interleukin-6 (IL-6) tumor necrosis factor- α (TNF- ). miRNA...

To develop a deep-learning-based automatic diagnosis system for identifying nasopharyngeal carcinoma (NPC) from noncancer (inflammation and hyperplasia), using both white light imaging (WLI) narrow-band (NBI) nasopharyngoscopy images.Retrospective study.A total of 4,783 images (2,898 WLI 1,885 NBI) 671 patients were collected novel deep convolutional neural network (DCNN) framework was developed named Siamese (S-DCNN), which can simultaneously utilize NBI to improve the classification...

The Framingham Steatosis Index (FSI) serves as a diagnostic metric for fatty liver. While research has established link between depression and liver, the association with remains undocumented. aim of this study is to explore potential correlation FSI depression, addressing void. Our data originates from National Health Nutrition Examination Survey (NHANES) database. We employed PHQ-9 questionnaire evaluation depressive symptoms. investigated using weighted multiple logistic regression model...

Objective: The study aimed to combine prenatal risk factors associated with early survival of patients prenatally diagnosed congenital diaphragmatic hernia (CDH) into a predictive nomogram. Study Design: We retrospectively analyzed 217 neonates CDH. who underwent surgery in an earlier period comprised the training cohort (n = 158) for nomogram development, while those subsequently constituted validation 59) verify model's performance. rate at discharge was regarded as primary outcome....

Introduction Fatty liver disease is potentially linked to chronic kidney (CKD), yet the association between Framingham Steatosis Index (FSI) and CKD remains uncharted. Our study thoroughly investigated correlation FSI CKD, aiming elucidate underlying links these two conditions. Methods The relationship was evaluated using a weighted multivariate logistic regression model, curvilinear explored through smooth curve fitting. We engaged recursive partitioning algorithm in conjunction with...

Background Depressive symptom, a pervasive mental health disorder, has garnered increasing attention due to its intricate interconnections with various physiological processes. One emerging avenue of investigation delves into the potential association between depressive symptom and Homeostasis Model Assessment Insulin Resistance (HOMA-IR), parameter reflecting insulin resistance. The interplay these two domains holds promising implications for understanding multifaceted nature impact on...

Objective: To compare the effectiveness and safety of da Vinci robot-assisted conventional laparoscopic surgery for hiatal hernia (HH) treatment in children after repair esophageal atresia (EA).

Abstract This study aimed to clarify and provide clinical evidence for which computed tomography (CT) assessment method can more appropriately reflect lung lesion burden of the COVID-19 pneumonia. A total 244 patients were recruited from three local hospitals. All assigned mild, common severe types. Semi-quantitative methods, e.g., lobar-, segmental-based CT scores opacity-weighted score, quantitative method, i.e., volume quantification, applied quantify lesions. four methods had high...

Gallbladder cancer (GBC) is commonly regarded as one of the most lethal malignant tumor types with poor prognosis. Kinesin family member 15 (KIF15) reported to be tightly related progression multiple which, however, has not been clarified in GBC so far. KIF15 was significantly up-regulated clinical tissues compared that para-carcinoma and expression level also correlated malignancies. In addition tissues, cells exhibited a high abundance KIF15. After down-regulating via lentiviral...