A5076009152- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Bladder and Urothelial Cancer Treatments
- Chronic Kidney Disease and Diabetes
- Bone health and osteoporosis research
- Cancer Immunotherapy and Biomarkers
- Urinary Bladder and Prostate Research
- Health Systems, Economic Evaluations, Quality of Life
- Peripheral Artery Disease Management
- Renal and Vascular Pathologies
- Biochemical effects in animals
- Diabetic Foot Ulcer Assessment and Management
- Neurological Disorders and Treatments
- Urological Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Pelvic floor disorders treatments
- Artificial Intelligence in Healthcare
- Aortic aneurysm repair treatments
- Abdominal Surgery and Complications
- Renal and related cancers
- Bone health and treatments
- Free Radicals and Antioxidants
- Urinary and Genital Oncology Studies
- Machine Learning in Healthcare
- Pancreatitis Pathology and Treatment
Heidelberg University
2021-2025
Institut für Medizinische Biometrie, Informatik und Epidemiologie
2022-2025
Zimmer Biomet (Germany)
2022-2024
Heidelberg University
2024
University Hospital Heidelberg
2024
German Center for Pediatric and Adolescent Rheumatology
2022
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Abstract There are currently five programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitors approved for the treatment of locally advanced or metastatic urothelial carcinoma (UC) bladder. For platinum-ineligible patients, testing tumor specimens PD-L1 expression is required. However, scoring immunohistochemistry complex due to different antibodies used, requirement score in cellular compartments and intratumoral heterogeneity. It can also be difficult obtain test longitudinal...
Background Cinacalcet is a calcimimetic approved in adults with primary hyperparathyroidism (PHPT). Few cases reports described its use pediatric HPT, challenges related to the risk of hypocalcemia, increased QT interval and drug interactions. In this study, we report French experience setting. Methods We retrospectively analyzed data from 18 patients 7 tertiary centers who received cinacalcet for PHPT. The results are presented as median (interquartile range). Results At age 10.8 (2.0–14.4)...
Carnosine and anserine supplementation markedLy reduce diabetic nephropathy in rodents. The mode of nephroprotective action both dipeptides diabetes, via local protection or improved systemic glucose homeostasis, is uncertain. Global carnosinase-1 knockout mice (Cndp1-KO) wild-type littermates (WT) on a normal diet (ND) high fat (HFD) (n = 10/group), with streptozocin (STZ)-induced type-1 diabetes 21-23/group), were studied for 32 weeks. Independent diet, Cndp1-KO had 2- to 10-fold higher...
Serum calcium isotopes (δ44/42Ca) have been suggested as a non-invasive and sensitive Ca balance marker. Quantitative δ44/42Ca changes associated with flux across body compartment barriers relative to the dietary correlation of δ44/42CaSerum bone histology are unknown. We analyzed by mass-spectrometry in rats after two weeks standard-Ca-diet (0.5%) four subsequent standard- low-Ca-diet (0.25%). In animals on net gain was 61 ± 3% femur content 68 41% standard-Ca-diet, mineralized area per...
Peritoneal dialysis (PD) is a life-sustaining kidney replacement therapy for the increasing number of people with permanent failure across all age groups worldwide. Although PD potentially offers socioeconomic and performance benefits over hemodialysis, both treatments severely accelerate complications chronic disease, in particular atherosclerotic disease progression that worsens outcomes when compared non-dialysis patients.1 Improved understanding underlying molecular pathogenic mechanisms...
Peritoneal dialysis (PD) is an increasingly needed, life-maintaining kidney replacement therapy; efficient solute transport critical for patient outcome. While the role of peritoneal perfusion on in PD has been described, cellular barriers uncertain, mesothelium considered irrelevant. We calculated blood microvascular endothelial surface area (BESA) to mesothelial (MSA) ratio human peritonea health, chronic disease, and PD, performed molecular related gene profiling single molecule...
Abstract BACKGROUND AND AIMS Paediatric patients with chronic kidney disease (CKD) develop significant atherosclerosis and vascular calcifications until early adulthood. Largely devoid of confounding lifestyle related factors underlying mostly limited to congenital abnormalities the kidneys urinary tract, these provide highly sensitive specific information on CKD-induced molecular mechanisms putative therapeutic targets. METHOD Standardized omental parietal peritoneal tissue samples from 95...
Background Exogenous carnosine and anserine mitigate diabetic nephropathy in rodents, whether they exert direct renal or indirect systemic effects is unknown. We studied carnosinase-1 KO (Cndp1-KO) mice with selectively 2-9-fold increased carnosine/anserine concentrations kidney under conditions.
Abstract Background and Aims Patients with chronic kidney disease patients (CKD) have an exceedingly high cardiovascular risk. While vasculopathy is further accelerated during peritoneal dialysis (PD), the pathophysiological role of reactive metabolites such as glucose degradation products (GDP) uncertain. Method Omental parietal tissues from 100 non-CKD individuals, 107 children CKD5, 60 treated neutral pH, low GDP, 30 acidic GDP PD fluids underwent standardized digital histomorphometry....