A5011334881- Prostate Cancer Diagnosis and Treatment
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Urological Disorders and Treatments
- Renal and related cancers
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Urinary and Genital Oncology Studies
- Urinary Tract Infections Management
- MRI in cancer diagnosis
- PARP inhibition in cancer therapy
- Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Anorectal Disease Treatments and Outcomes
- Dialysis and Renal Disease Management
- Hormonal and reproductive studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Genital Health and Disease
- Pediatric Urology and Nephrology Studies
- Medical and Health Sciences Research
- Infectious Disease Case Reports and Treatments
Heidelberg University
2014-2023
University Hospital Heidelberg
2014-2023
Hegau-Bodensee-Klinikum Singen
2023
National Center for Tumor Diseases
2015-2021
University Medical Center of the Johannes Gutenberg University Mainz
2020
Johannes Gutenberg University Mainz
2020
Roth and Rau (Germany)
2018
Tokyo Fuji University
2018
Chirurgische Universitätsklinik Heidelberg
2010-2017
Detroit Medical Center
2014
We investigated the influence of bladder neck preservation on urinary continence, quality life and surgical margins after radical prostatectomy.A total 208 men who presented for prostatectomy were randomized to complete with subsequent urethro-urethral anastomosis or no as controls. Patients failed not included in study. documented objective continence by 24-hour pad test, social number pads per day outcomes validated Incontinence Quality Life questionnaire a single blind setting. Cancer...
Abstract The peritoneum plays an essential role in preventing abdominal frictions and adhesions can be utilized as a dialysis membrane. Its physiological ultrastructure, however, has not yet been studied systematically. 106 standardized peritoneal 69 omental specimens were obtained from 107 patients (0.1–60 years) undergoing surgery for disease affecting the automated quantitative histomorphometry immunohistochemistry. mesothelial cell layer morphology protein expression pattern is similar...
Intratumoural heterogeneity (ITH) is a major cause of cancer-associated lethality. Extensive genomic ITH has previously been reported in clear cell renal carcinoma (ccRCC). Here we address the question whether increases with malignant progression and can hence be exploited as prognostic marker. Unexpectedly, precision quantitative image analysis reveals that degree functional virtually identical between primary ccRCCs lowest stage advanced, metastatic tumours. Functional was found to show...
<b><i>Introduction:</i></b> We analysed the impact of predefined risk factors: age, diabetes, history pelvic irradiation, prior surgery for stress urinary incontinence (SUI), urethral stricture, additional procedure during SUI surgery, duration incontinence, ASA-classification and cause on failure complications in male surgery. <b><i>Materials Methods:</i></b> retrospectively identified 506 patients with an artificial sphincter (AUS) 513 a...
Retzius-sparing robot-assisted laparoscopic radical prostatectomy (rsRARP) allows entire procedure via the pouch of Douglas. In low- and intermediate-risk prostate cancer (PCa) there is level 1 evidence that approach impacts early continence recovery. Since specific data on aggressive locally advanced lacking avoiding rsRARP presently suggested, we investigated urinary sexual recovery, perioperative complications oncologic outcomes after in this particular cohort.Prospectively collected 50...
<b><i>Background/Aims/Objectives:</i></b> To analyze perioperative complication and short-term explantation rates after perineal or penoscrotal single-cuff double-cuff artificial urinary sphincter (AUS) implantation in a large middle European multi-institutional patient cohort. <b><i>Methods:</i></b> 467 male patients with stress incontinence underwent of (n = 152), 99), 216) AUS between 2010 2012. Postoperative complications 6-month were...
Harninkontinenz ist neben Störungen der erektilen Funktionsfähigkeit die häufigste Funktionseinschränkung nach radikaler Prostatektomie (RPE) beim Prostatakarzinom (PCa). Die deutsche S3-Leitlinie empfiehlt, Patienten über mögliche Auswirkungen Therapieoptionen zu informieren (darunter Inkontinenz). Allerdings liegen bislang nur ungenaue Daten zur Kontinenz aus Routineversorgung im deutschsprachigen Raum RPE vor, was Information erschwert. Ziel dieser Arbeit es, Häufigkeit und Ausprägung...
Magnetic resonance imaging (MRI) and prostate specific membrane antigen (PSMA)- positron emission tomography (PET)/computed (CT)-imaging of cancer (PCa) are emerging techniques to assess the presence significant disease tumor progression. It is not known, however, whether what extent lesions detected by these correlate with genomic features PCa. The aim this study was therefore define a index lesion based on chromosomal copy number alterations (CNAs) as marker for aggressiveness in biopsies...
Abstract A venous tumor thrombus (VTT) is a potentially lethal complication of renal cell carcinoma (RCC) but virtually nothing known about the underlying natural history. Based on our observation that thrombi contain significant numbers viable cells, we applied multiregion whole exome sequencing to total 37 primary and VTT samples including normal tissue specimens from five consecutive patients. Our findings demonstrate mutational heterogeneity between with 106 483 genes (22%) harboring...
Mutations in DNA damage repair genes, particular genes involved homology-directed repair, define a subgroup of men with prostate cancer more unfavorable prognosis but therapeutic vulnerability to PARP inhibition. In current practice, mutational testing patients is commonly done late i.e., when the tumor castration resistant. addition, most sequencing panels do not include TP53, one crucial suppressor human cancer. this proof-of-concept study, we sought extend clinical use these molecular...
Objective . The great possibility of variations in the clinical presentation hypospadia, makes its therapy challenging. This has led to development a number techniques for hypospadia repair. article assesses past and present concepts operative with aim broadening our understanding this malformation. Materials Methods not only reviews general as well historical current hypospadiologie on basis available literature, but it is also based own experience repair Results Conclusion fact that there...
Background Risk models (RM) need external validation to assess their value beyond the setting in which they were developed. We validated a RM combining mpMRI and clinical parameters for probability of harboring significant prostate cancer (sPC, Gleason Score ≥ 3+4) biopsy-naïve men. Material methods The original was based on data 670 men from Heidelberg University Hospital who underwent with PI-RADS scoring prior MRI/TRUS-fusion biopsy 2012–2015. Validity tested by consecutive cohort (n =...
The aim was to study the correlation between cuff size and outcome after implantation of an AMS 800 artificial urinary sphincter.A total 473 male patients with sphincter implanted 2012 2014 were analyzed in a retrospective multicenter cohort performed as part Central European Debates on Male Incontinence (DOMINO) Project.Single cuffs 54.5% double 45.5% patients. used had median circumference 4.5 cm. Within follow 18 months, urethral erosion occurred 12.8% cases associated significantly more...
Defects in DNA damage repair genes characterize a subset of men with prostate cancer and provide an attractive opportunity for precision oncology approaches. The prevalence such perturbations newly diagnosed, treatment-naïve patients high risk lethal disease outcome, however, has not been sufficiently explored. Prostate specimens from 67 diagnosed early onset, localized high-risk/locally advanced or metastatic were included this prospective pilot study. Tumor samples, including 30 biopsies,...
Abstract There are currently five programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitors approved for the treatment of locally advanced or metastatic urothelial carcinoma (UC) bladder. For platinum-ineligible patients, testing tumor specimens PD-L1 expression is required. However, scoring immunohistochemistry complex due to different antibodies used, requirement score in cellular compartments and intratumoral heterogeneity. It can also be difficult obtain test longitudinal...