A5053220989- Carcinogens and Genotoxicity Assessment
- Animal testing and alternatives
- Skin Protection and Aging
- Air Quality and Health Impacts
- Indoor Air Quality and Microbial Exposure
- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Environmental Toxicology and Ecotoxicology
- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Curcumin's Biomedical Applications
- Cancer Cells and Metastasis
- Biomarkers in Disease Mechanisms
- Healthcare and Environmental Waste Management
- Sustainable Building Design and Assessment
- Toxin Mechanisms and Immunotoxins
- Photosynthetic Processes and Mechanisms
- Synthesis of Indole Derivatives
- Natural Antidiabetic Agents Studies
- Chemical Safety and Risk Management
- Bladder and Urothelial Cancer Treatments
- Biocrusts and Microbial Ecology
- Biochemical and biochemical processes
- Catalysis for Biomass Conversion
- Carbohydrate Chemistry and Synthesis
Lebanese American University
2015-2025
Evangelisches Krankenhaus Oberhausen
2023
UNSW Sydney
1997-2019
Exposure to vapours of volatile chemicals is a major occupational and environmental health concern. Toxicity testing organic compounds (VOCs) has always faced significant technological problems due their high volatility and/or low solubility. The aim this study was develop practical reproducible in vitro exposure technique for toxicity VOCs. Standard test atmospheres xylene toluene were generated glass chambers using static method. Human cells including: A549-lung derived cell lines,...
The focus of this research was on UVB radiation (280-320 nm) responsible for cellular changes in skin acute and chronically exposed individuals. This study investigated the damages triggered by exposure cultured human fibroblasts keratinocyte cells immediately 24 h post order to understand damage onset progression. evaluated a number parameters including mitochondria, lysosomes, cell membrane, DNA as well pro anti-apoptotic protein expression levels. Cellular organelle were assessed battery...
An earth-abundant cuprous bis-phenanthroline photosensitizer showed potential use in the photodynamic therapy of cancer.
Harninkontinenz ist neben Störungen der erektilen Funktionsfähigkeit die häufigste Funktionseinschränkung nach radikaler Prostatektomie (RPE) beim Prostatakarzinom (PCa). Die deutsche S3-Leitlinie empfiehlt, Patienten über mögliche Auswirkungen Therapieoptionen zu informieren (darunter Inkontinenz). Allerdings liegen bislang nur ungenaue Daten zur Kontinenz aus Routineversorgung im deutschsprachigen Raum RPE vor, was Information erschwert. Ziel dieser Arbeit es, Häufigkeit und Ausprägung...
Abstract We have evaluated in vitro cytotoxicity of cyanobacterial phycoerythrin (C‐PE) on three human cell lines by proliferation and neutral red uptake assays. No toxic effects C‐PE were observed to any the tested. The protective role purified potassium permanganate‐mediated fibroblast‐DNA damage was assessed comet assay at 0 (control), 10 20 µg ml −1 doses pre‐, simultaneous post‐mutagen exposure conditions. Significant DNA detected only Our findings confirmed that is non‐toxic provides...
A novel platinum(II) complex 47OMESS(II) and its platinum(IV) derivative 47OMESS(IV) were synthesized characterized. Cytotoxicity studies against mesenchymal cells (MCs) lung (A549), breast (MDA-MB-231), melanoma (A375) cancer demonstrated 7–20-fold superior activity for both complexes relative to cisplatin. Remarkably, 17–22-fold greater selectivity toward the cancerous compared non-cancerous MCs. Western blot analysis on A549 showed involvement of intrinsic apoptotic pathway. Cellular...
The purpose of this study was to identify a suitable sampling model for on-site toxicity assessment soluble air contaminants such as formaldehyde, well known industrial and indoor contaminant. in vitro cytotoxicity the selected contaminants, studied using MTS (tetrazolium salt) assay two carcinoma cell lines, A549 epithelial lung HepG2 hepatocarcinoma, skin fibroblasts. cytotoxic effects airborne formaldehyde were evaluated test atmospheres concentrations below 10 ppm (12.3 mg/m 3 ),...
Nowadays there is a great deal of concern resulting from the impact UV light on human skin especially when damage levels are predicted to rise due ozone layer depletion. The acts as an important biological barrier, and plays physiological immunological role. This study reports UVB-induced effect derived primary fibroblasts one most abundant cells in dermis. Two time points, immediately 24 hour post UVB exposure were used measure magnitude cytotoxicity. induced cell membrane was assessed by...
Gasoline exposure has been widely reported in the literature as being toxic to human health. However, exact underlying molecular mechanisms triggered by its inhalation have not thoroughly investigated. We herein present a model of sub-chronic, static gasoline vapor adult female C57BL/6 mice. Animals were exposed daily either vapors (0.86 g/animal/90 min) or ambient air for 5 days/week over 7 consecutive weeks. At end study period, and inflammatory, oxidative, apoptotic effects vapors,...
This article represents an approach for dealing with the environmental impacts that are associated daily activities of a research facility in Australia. The principles were observed this regard followed guidelines established AS/NZ standard ISO 14001 (1996) development Environmental Management System (EMS) (1). implementation EMS to laboratory was not as straightforward previously thought. Different means achieving requirements considered before setting up interim system. Some major setbacks...
Objectives: Nargile (waterpipe) smoking has gained popularity in the Middle East and throughout world. In this research, a new dynamic methodology was conceived. This deployed for direct vitro assessment of cytotoxicity, genotoxicity, apoptotic potential smoke generated from single nargile session. Materials methods: A549 cells were designed system to assess cytotoxicity smoke. The characterized using Gas chromatography–mass spectrometry (GC-MS) profiling major organic compounds, whereas...